Review
Food Science & Technology
Wieneke Dijk, Caterina Villa, Sara Benede, Emilia Vassilopoulou, Isabel Mafra, Maria Garrido-Arandia, Monica Martinez Blanco, Gregory Bouchaud, Tamara Hoppenbrouwers, Simona Lucia Bavaro, Linda Giblin, Karen Knipping, Ana Maria Castro, Susana Delgado, Joana Costa, Shanna Bastiaan-Net
Summary: New types of protein sources entering our diet require a straightforward in vitro screening model to predict the safety and potential risk for allergic sensitization. However, there is no consensus on the in vitro model to study protein translocation and epithelial activation, which are crucial events in allergic sensitization. INFOGEST members have highlighted critical features and defined indispensable and optional intestinal cell types for a consensus model to study epithelial protein transport in the context of allergic sensitization.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Nadya Armenova, Lidia Tsigoriyna, Alexander Arsov, Kaloyan Petrov, Penka Petrova
Summary: The use of pesticides in agricultural areas is essential for improving crop yields in the future. However, the ingestion of food with pesticide residues can lead to serious health issues such as neurological, gastrointestinal, and allergic reactions, as well as cancer and death. Fortunately, the fermentation process reduces pesticide residues in certain foods through enzymatic degradation by microbial species. This review focuses on highly pesticide-contaminated foods, such as milk, yogurt, fermented vegetables, fruit juices, grains, sourdough, and wines, and discusses the molecular mechanisms and potential strategies for pesticide detoxification.
Article
Biochemistry & Molecular Biology
Julieta S. De Anna, Flavia Bieczynski, Juan Guillermo Carcamo, Andres Venturino, Carlos M. Luquet
Summary: Chlorpyrifos, a widely detected organophosphorus pesticide, affected the transport activity of Abcc proteins and enzyme activities in rainbow trout fish in North Patagonia, Argentina. However, exposure to chlorpyrifos did not influence the expression levels of studied genes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Physics, Multidisciplinary
Agnese Codutti, Jonas Cremer, Karen Alim
Summary: Small intestine motility and flow play a crucial role in nutrient absorption and bacterial growth. Our observations on mice suggest that the average flow velocity is the key factor affecting absorption efficiency and bacterial growth.
PHYSICAL REVIEW LETTERS
(2022)
Article
Endocrinology & Metabolism
Huiyuan Zheng, Lorena Lopez-Ferreras, Jean-Phillipe Krieger, Stephen Fasul, Valentina Cea Salazar, Natalia Valderrama Pena, Karolina P. Skibicka, Linda Rinaman
Summary: The study presented a novel Gcg-Cre rat model for studying the development, anatomy, and function of Gcg-expressing cells in the brain and periphery. The homozygous Gcg-Cre rats showed lower plasma glucose levels and exhibited cell expression in brain regions that do not match Gcg expression. Stimulation of specific brain regions' GLP1 neurons reduced food intake in male rats but not in female rats.
MOLECULAR METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Daniele Piovani, Cesare Hassan, Alessandro Repici, Lorenza Rimassa, Carmelo Carlo-Stella, Georgios K. Nikolopoulos, Elio Riboli, Stefanos Bonovas
Summary: This study summarized the epidemiologic evidence and validity of associations between inflammatory bowel diseases (IBDs) and overall and site-specific cancer risk. The results showed varying levels of evidence and magnitude of risk for different types of malignancy. Further research is needed to investigate the impact of risk factors known to affect cancer risk.
Review
Gastroenterology & Hepatology
Daniele Piovani, Cesare Hassan, Alessandro Repici, Lorenza Rimassa, Carmelo Carlo-Stella, Georgios K. Nikolopoulos, Elio Riboli, Stefanos Bonovas
Summary: This study critically evaluated the associations between inflammatory bowel diseases (IBDs) and various types of cancer, demonstrating different levels of evidence and risk magnitude for different types of malignancy.
Review
Food Science & Technology
Marcella Duarte Villas Mishima, Hercia Stampini Duarte Martino, Talitha Silva Meneguelli, Elad Tako
Summary: Dietary proteins release bioactive peptides that have positive effects on gut health and inflammation mediators. This systematic review aims to understand the impact of these peptides derived from animal and plant sources on gut health and inflammation in vivo. The analysis of 11 animal studies showed that the bioactive peptides reduced inflammation markers, improved gut health indicators, and increased the diversity of gut microbiota. However, more in vivo studies are needed to fully understand the anti-inflammatory activity and mechanisms of these peptides. PROSPERO (CRD42023416680).
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Environmental Sciences
Zaid Ulhassan, Javaid Akhter Bhat, Weijun Zhou, Ahmed M. Senan, Pravej Alam, Parvaiz Ahmad
Summary: Excessive arsenic accumulation in plant tissues can have toxic impacts on growth and human health. Engineered nanoparticles (ENPs) have been found to reduce arsenic accumulation and toxicity, but the mechanisms are not fully understood.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biotechnology & Applied Microbiology
Feimin Yuan, Cong Wei
Summary: Malpighian tubules (MTs) in the vector leafhopper P. striatus perform multiple physiological functions including osmoregulation, organic solute transport, detoxification, immunity, and brochosomes biosynthesis. Different regions of MTs target different substrates and play roles in eliminating invading pathogens. These functions help P. striatus resist pathogens and utilize a wider range of host plants, facilitating the transmission and spread of phytoplasmas. The results provide potential molecular targets for the development of insecticides.
Article
Environmental Sciences
Ehsan Ahmadifar, Naser Kalhor, Mahmoud A. O. Dawood, Mehdi Ahmadifar, Mohsen Shahriari Moghadam, Safoura Abarghouei, Aliakbar Hedayati
Summary: The study aimed to evaluate the adverse impacts of polystyrene microparticles (PS-MPs) on inflammation, immune, and antioxidative responses in Nile tilapia. Results showed that exposure to PS-MPs led to significant changes in antioxidative, inflammatory, and detoxification-related genes in the fish, indicating potential detrimental effects on their health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Yang Lyu, Yimin Chen
Summary: Digested human colostrum significantly reduces IL-8 production in human intestinal epithelial cells stimulated with LPS and TNF. However, individual colostrum samples exhibit wide variance in their ability to suppress inflammation and cytotoxicity.
Article
Nutrition & Dietetics
Mei You, Rui Liu, Chan Wei, Xiujuan Wang, Xiaochen Yu, Zhen Li, Ruixue Mao, Jiani Hu, Na Zhu, Xinran Liu, Rui Fan, Yong Li, Meihong Xu
Summary: This study demonstrates that exogenous nucleotides (NTs) can increase bodyweight, improve the morphological structure of the intestine, promote the secretion of intestinal protective factors, suppress intestinal inflammation, and improve intestinal immunity in ageing mice, possibly by activating the p38 signaling pathway. These results suggest that exogenous NTs are able to maintain the health condition of the ageing intestine.
Review
Toxicology
Frederick Barreau, Celine Tisseyre, Sandrine Menard, Audrey Ferrand, Marie Carriere
Summary: The intestinal barrier function is crucial for protecting the body from harmful substances and its dysfunction is associated with various human diseases. In addition to genetic factors, environmental influences such as the use of food additives may also impact the intestinal barrier function.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Environmental Sciences
Golam Jalal Ahammed, Youxin Yang
Summary: Plants detoxify toxic metals by accumulating diverse metabolites, with some metabolites chelating metal ions. In addition to classical detoxification pathways involving thiol-containing compounds, secondary metabolites like anthocyanins have emerged as playing a significant role in metal detoxification. Anthocyanins, with their ability to scavenge reactive oxygen species, contribute to enhanced arsenic tolerance in plants and may offer potential for improving crop yield and food safety in arsenic polluted areas.
ENVIRONMENTAL POLLUTION
(2022)