Article
Biotechnology & Applied Microbiology
Min-Jeong Cheon, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Heat-killed Lactobacillus plantarum 200655 has been found to increase levels of brain-derived neurotrophic factor (BDNF) and protect neuronal cells from oxidative stress, while also reducing apoptosis-related gene ratios. These findings suggest that L. plantarum 200655 may serve as a prophylactic functional ingredient for preventing neurodegenerative diseases.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Food Science & Technology
O. S. Fadare, V. Singh, O. I. Enabulele, O. H. Shittu, D. Pradhan
Summary: The study aimed to screen potential probiotic strains of Lactobacillus species for their synbiotic antibacterial action with garlic extract against Salmonella strains. L. plantarum NG6 was identified as the best probiotic lactobacilli, and the combination of garlic extract and Lactobacillus strains demonstrated synergistic antimicrobial action against Salmonella strains. This study suggests that probiotics can be combined with herbal preparations like garlic to combat gastrointestinal infections.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sini Kang, Yaqing Guo, Junhui Rao, Hui Jin, Hyun Ju You, Geun Eog Ji
Summary: Helicobacter pylori infection is the most common cause of gastritis and gastric ulcers. A study investigated the anti-H. pylori effects of Lactobacillus plantarum strain pH3A, monolaurin, grapefruit seed extract (GSE), and their synergies in vitro and in vivo. The L. plantarum pH3A strain showed potential as an alternative anti-H. pylori therapy, but further evidence is needed for its synergy with monolaurin or GSE in vivo.
Article
Nutrition & Dietetics
Gyeol Seong, Seungbaek Lee, Yang Won Min, Yeon Sil Jang, Hong Seog Kim, Eui-Joong Kim, So-Young Park, Cheol-Hyun Kim, Dong Kyung Chang
Summary: The study found that heat-killed L. casei DKGF7 can improve stool consistency in a rat IBS model, indicating a potential therapeutic strategy for IBS treatment.
Article
Biochemistry & Molecular Biology
Chang-Hoon Hwang, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Recent research has focused on the anti-cancer properties of Lactobacillus strains isolated from fermented foods. The study found that their anti-cancer effects are achieved by inducing apoptosis in cancer cells. However, consuming living organisms can lead to sepsis, especially in cancer patients with reduced immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Qinfeng Ding, Xuecheng Sun, Shuai Cao, Cancan Zhao, Yitong Wang, Xudong Wang
Summary: Heat-killed Lactobacillus acidophilus can coaggregate with Fusobacterium nucleatum, inhibit its adhesion and invasion, reduce pro-inflammatory cytokine production in oral epithelial cells, and suppress virulence gene expression in F. nucleatum, potentially benefiting periodontal health by modulating periodontal pathogen virulence.
FEMS MICROBIOLOGY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Ta-Chin Lin, I-Ling Hsu, Wan-Hua Tsai, Yi-Chih Chu, Lung-Ching Kuan, Min-Syuan Huang, Wen-Ling Yeh, Ya-Hui Chen, Shan-Ju Hsu, Wen-Wei Chang
Summary: The study found that VGA-1, a potential agent for bacterial vaginosis (BV) intervention, showed improvement effects in BV patients and reduced recurrent rates. Among the two lactobacillus formulas tested, VGA-1 demonstrated superior efficacy in improving symptoms and reducing recurrent rates in BV patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Microbiology
Brianda D. Gonzalez-Orozco, Erica Kosmerl, Rafael Jimenez-Flores, Valente B. Alvarez
Summary: In this study, co-cultures of L. kefiranofaciens OSU-BDGOA1 and K. marxianus bdgo-ym6 were found to have higher survival rates during simulated digestion and enhanced adhesion to intestinal cells compared to monocultures. The increased production of EPS during co-culture protected the microorganisms from harsh gastrointestinal conditions. Additionally, both monoculture and co-culture of OSU-BDGOA1 regulated inflammation and improved membrane barrier integrity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hye-Ji Noh, Jung Min Park, Yoo Jin Kwon, Kyunghwan Kim, Sung Yurb Park, Insu Kim, Jong Hyun Lim, Byoung Kook Kim, Byung-Yong Kim
Summary: Heat-killed LP8 modulates immune responses through different mechanisms, including enhancing phagocytic activity of macrophages, inducing pro-inflammatory cytokine production, and suppressing immune responses to pathogen infections.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Agata Twardowska, Adam Makaro, Agata Binienda, Jakub Fichna, Maciej Salaga
Summary: Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability. Changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokines can lead to intestinal hyperpermeability and the development of various diseases. Translocation of microorganisms and their toxic metabolites beyond the gastrointestinal tract can cause chronic inflammation and progression of disorders. Dietary intervention has shown potential in improving barrier function and restricting bacterial invasion, but there are no medical guidelines for the treatment or prevention of bacterial translocation in patients with leaky gut syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Charley Cull, Vijay K. Singu, Brooke J. Cull, Kelly F. Lechtenberg, Raghavendra G. Amachawadi, Jennifer S. Schutz, Keith A. Bryan
Summary: This study aimed to demonstrate the effectiveness of using Lactobacillus animalis and Propionibacterium freudenreichii as direct-fed microbials in reducing the adverse effects of Salmonella infection in beef calves. The results showed that the presence of bacteria in feces was significantly lower in the probiotic group compared to the control group. The probiotic-fed calves also had better health scores and a lower presence of abnormal diarrhea. These findings support the potential economic and health benefits of using effective probiotics in animal feed.
Article
Fisheries
Julie Ekasari, Vini Nur Mirza, Ichsan Achmad Fauzi, Kyohei Hashimoto, Muhammad Agus Suprayudi
Summary: This research aims to evaluate the supplementation of heat-killed Lactobacillus plantarum at higher dosages and investigate its effect against Streptococcus agalactiae. A feeding and disease challenge trial were conducted, and the results indicate that heat-killed L. plantarum L-137 can improve tilapia growth performance and enhance resistance against S. agalactiae infection. Therefore, a recommended supplementation level of 10-20 mg/kg LP20 feed for tilapia growth and 250 mg/kg LP20 feed for protection against S. agalactiae.
AQUACULTURE NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Ashraf Khalifa, Hairul Islam Mohamed Ibrahim
Summary: In this study, beneficial probiotics, specifically Enterococcus faecium, were isolated from broiler chicken carcasses and found to improve chicken health against Salmonella infections. Chickens fed with E. faecium showed improved body weight, reduced mortality, and lower levels of S. enterica. The presence of E. faecium also led to increased levels of short-chain fatty acids and reduced levels of pro-inflammatory markers. These findings highlight the potential of E. faecium as a preventive measure against bacterial infections in broiler chickens.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Food Science & Technology
Yongzhao Xu, Shiying Nie, Min Wang, Zikuan Zhao, William Kwame Amakye, Erdong Yuan, Jiaoyan Ren
Summary: A peptide derived from walnut-protein (PW5) has been found to counteract the inhibitory effect of polystyrene microplastic (PS-MP) on probiotics by forming new complexes through hydrogen bonding and van der Waals forces. This study reveals the interaction mechanism between food-derived peptides and microplastic, providing a new approach to reduce the health risks posed by microplastic using food-derived bioactive peptides.
Article
Nutrition & Dietetics
Zhixin Xie, Gongsheng Zhang, Rongxu Liu, Yucong Wang, Anna N. N. Tsapieva, Lili Zhang, Jianchun Han
Summary: The study found that heat-killed Lacticaseibacillus paracasei (HK-LP) has beneficial effects on intestinal epithelial barrier function, improving intestinal health and enhancing immunity. HK-LP 6105, 6115, and 6235 were shown to improve intestinal barrier dysfunction induced by lipopolysaccharide (LPS) by modulating inflammatory responses and tight junction protein expression. They also exhibited anti-inflammatory effects by inhibiting pro-inflammatory factors and increasing the expression of anti-inflammatory factors.