Article
Plant Sciences
Xiaona Zhang, Xue Peng, Guimin Yang, Qingfu Chen, Daochao Jin
Summary: This study evaluated the ability of Isaria cateniannulata to invade buckwheat plants and its impact on plant defense enzyme activity and physiological indexes. It was found that I. cateniannulata could enter buckwheat leaves through stomata and veins, enhance defensive enzyme activity, and promote plant growth.
Article
Multidisciplinary Sciences
Ewelina Wozniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Wozniak, Paulina Gorzelak-Pabis
Summary: The study compared the pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory and anti-inflammatory genes in endothelial cells damaged by 25-OHC. The results showed that rosuvastatin had the strongest anti-inflammatory effects and was most effective at reducing the effect of oxysterols. Both statins had stronger anti-inflammatory effects compared to ezetimibe. The combination therapies' anti-inflammatory effects seemed to be based on the statins alone, rather than their combination with ezetimibe.
Article
Immunology
Fatemeh Abbasi, Parvin Shawrang, Farahnaz Motamedi-Sedeh, Maryam Sadeghi
Summary: The effect of gamma-irradiated honey bee venom at different doses on allergen compounds and cytokine gene expression was investigated. The results showed that irradiation at 4, 6, and 8 kGy reduced edema activity induced by the bee venom, while 2 kGy irradiation increased it. Gene expression of IFN-gamma, IL-6, and IL-10 decreased with irradiation at 4, 6, and 8 kGy, compared to the control group and 2 kGy irradiation. However, at 8 kGy irradiation, there was an increase in gene expression of IFN-gamma and IL-6 compared to 4 and 6 kGy irradiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Applied
Mohammed S. Almuhayawi, Abdelrahim H. A. Hassan, Mohamed Abdel-Mawgoud, Galal Khamis, Samy Selim, Soad K. Al Jaouni, Hamada AbdElgawad
Summary: Research has shown that using He-Ne laser (632 nm, 5 mW) treatment on buckwheat sprouts can significantly increase the levels of various health-promoting compounds. Laser treatment not only enhances antioxidant capacity and anti-inflammatory activities, but also improves the content of minerals, metabolites, and enzymes in the sprouts.
Article
Integrative & Complementary Medicine
Jiha Byun, Su Kang Kim, Ju Yeon Ban
Summary: The study evaluated the protective effects of Korean ginseng berry extract (KGB) on LPS-induced inflammation and found that KGB can inhibit cytokine production, reduce expression of inflammation-related genes, and decrease oxidative stress through multiple pathways. These results suggest that KGB may have the potential to be a therapeutic agent for inflammatory and oxidative stress-related diseases.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Cell Biology
Onofrio Laselva, Caterina Allegretta, Sante Di Gioia, Carlo Avolio, Massimo Conese
Summary: DMF demonstrates anti-inflammatory and antioxidant effects in CF treatment, reducing inflammatory responses, restoring CFTR function, and potentially serving as a novel drug to ameliorate lung inflammation in CF patients and enhance drug efficacy.
Article
Biochemistry & Molecular Biology
Sho Yamazaki, Keisuke Yamaguchi, Akimasa Someya, Isao Nagaoka, Masakazu Hayashida
Summary: Dexmedetomidine may alleviate delirium by exhibiting anti-inflammatory action on microglial cells. The study found that Dexmedetomidine suppressed the production of inflammatory cytokines and inhibited the activation of related signaling pathways in both stimulated and unstimulated microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ya Wang, Zihan Nie, Tingjun Ma
Summary: This study investigated the effects of treating buckwheat sprout with plasma-activated water (PAW) on its quality, nutrients, functional active ingredients, and antioxidant activity during germination. The results showed that PAW treatment had a positive impact on the germination rate and stem growth of the sprouts. Sensory evaluation revealed that the treated sprouts had desirable appearance and texture. The PAW-treated sprouts also exhibited higher water content, amino acids, and reducing sugars, as well as gradual increase in flavonoids, phenolic acids, gamma-GABA, polysaccharides, and antioxidant activity. These findings suggest that PAW treatment has the potential to enhance the antioxidant properties and health benefits of buckwheat sprouts as a dietary source.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Edina Pandur, Kitti Tamasi, Ramona Pap, Gergely Janosa, Katalin Sipos
Summary: This study focused on the modulatory effects of fractalkine on the immune response and iron metabolism. Results showed that fractalkine could regulate iron metabolism in THP-1 cells and alter the levels of signaling proteins involved in the expression of pro-inflammatory cytokines and iron storage and utilization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Deming Sun, Nymph Chan, Hui Shao, Willi K. Born, Henry J. Kaplan
Summary: Gamma delta T cells play a significant role in immune regulation, and their activation status and pathway impact their functions. In this study, it was shown that activated gamma delta T cells under different inflammatory conditions differ in functions.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Hyo-Jin An, Ji-Young Lee, Wansu Park
Summary: This study found that baicalin can inhibit the inflammatory response of macrophages activated by LPS, reduce the production of various inflammatory mediators, suppress oxidative stress, decrease the levels of phosphorylated p38 MAPK and Fas protein, and inhibit the expression of inflammatory genes.
Review
Immunology
Fenyao Li, Xinxin Wang, Jin Shi, Shuting Wu, Wenbo Xing, Yan He
Summary: Dental pulp stem cells have strong immunomodulatory capabilities and can be used to treat inflammation-related diseases and autoimmune disorders. The mechanism of action is complex and may involve the regulation of immune cells through inflammatory immune-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dabin Jeong, Wan-Kyu Ko, Seong-Jun Kim, Gong-Ho Han, Daye Lee, Seung-Hun Sheen, Seil Sohn
Summary: LOBE significantly reduces NO production and pro-inflammatory gene expression in LPS-induced BMDMs, potentially through inhibition of the MAPK signaling pathway by reducing phosphorylation levels of ERK and JNK.
Article
Biochemistry & Molecular Biology
Hyun Jung Park, Sung Won Lee, Jae Geun Song, Luc Van Kaer, Jae Hee Cheon, Soo-Jeong Lim, Hyo-Kyung Han, Seokmann Hong
Summary: Study found that aminoclay nanoparticles have anti-inflammatory effects on murine dendritic cells (DCs) and can attenuate inflammatory responses and inhibit the production of specific cytokines, which has therapeutic potential for controlling inflammatory disorders.
Article
Multidisciplinary Sciences
Liliana M. Sanmarco, Michael A. Wheeler, Cristina Gutierrez-Vazquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat, Francisco J. Quintana
Summary: This study identifies a subset of astrocytes that limit inflammation in the central nervous system by inducing T cell apoptosis through TRAIL-DR5 signaling. The expression of TRAIL in these astrocytes is regulated by interferon-gamma produced by meningeal NK cells, which is modulated by the gut microbiome.
Article
Biochemistry & Molecular Biology
Satoshi Ishii, Atsumi Taguchi, Nozomu Okino, Makoto Ito, Hiroki Maruyama
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Optics
Yoshitaka Jin, Tomoaki Nishizawa, Nobuo Sugimoto, Shoken Ishii, Makoto Aoki, Kaori Sato, Hajime Okamoto
Correction
Astronomy & Astrophysics
Fumitaka Nakamura, Shuri Oyamada, Sachiko Okumura, Shun Ishii, Yoshito Shimajiri, Yoshihiro Tanabe, Takashi Tsukagoshi, Ryohei Kawabe, Mumetake Momose, Yumiko Urasawa, Ryoichi Nishi, Sheng-Jun Lin, Shih-Ping Lai, Kazuhito Dobashi, Tomomi Shimoikura, Koji Sugitani
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN
(2020)
Article
Biochemistry & Molecular Biology
Yasuhiro Shimada, Katsuyuki Sato, Mika Masaki, Takashi Nakamura, Yoshihiko Tokuji
Summary: Ge-132, a water-soluble organogermanium compound, has immunostimulatory and antiviral effects by interacting with sugars. The study found that THGP mainly forms complexes with sugars in aqueous solutions via cis-diol groups, exhibiting higher affinity for ketose than aldose. The interaction between THGP and sugars is influenced by the number of cis-diol groups on the sugar structure.
CARBOHYDRATE RESEARCH
(2021)
Article
Astronomy & Astrophysics
Hideaki Takemura, Fumitaka Nakamura, Shuo Kong, Hector G. Arce, John M. Carpenter, Volker Ossenkopf-Okada, Ralf Klessen, Patricio Sanhueza, Yoshito Shimajiri, Takashi Tsukagoshi, Ryohei Kawabe, Shun Ishii, Kazuhito Dobashi, Tomomi Shimoikura, Paul F. Goldsmith, Alvaro Sanchez-Monge, Jens Kauffmann, Thushara G. S. Pillai, Paolo Padoan, Adam Ginsberg, Rowan J. Smith, John Bally, Steve Mairs, Jaime E. Pineda, Dariusz C. Lis, Blakesley Burkhart, Peter Schilke, Hope How-Huan Chen, Andrea Isella, Rachel K. Friesen, Alyssa A. Goodman, Doyal A. Harper
Summary: By analyzing 692 dense cores in the Orion Nebula Cluster region, comparing core and initial stellar mass functions, and studying the star formation rate, it was found that gravitational bound cores play a crucial role in determining the final stellar masses of stars. The core mass function shows similarities to the stellar initial mass function, and additional gas accretion from the surroundings is necessary to reproduce the current IMF.
ASTROPHYSICAL JOURNAL LETTERS
(2021)
Article
Optics
Tomoaki Nishizawa, Yoshitaka Jin, Nobuo Sugimoto, Kaori Sato, Masahiro Fujikawa, Shoken Ishii, Makoto Aoki, Katsuhiro Nakagawa, Hajime Okamoto
Summary: The study developed a 355 nm multiple-field-of-view multiple-scattering polarization lidar to investigate cloud and aerosol microphysics and provide microphysical properties of clouds and aerosols. Aerosol signals and their multiple scattering contributions were generally more pronounced at 355 nm, highlighting the advantage of performing measurements at this wavelength.
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2021)
Article
Astronomy & Astrophysics
Yusuke Miyamoto, Atsushi Yasuda, Yoshimasa Watanabe, Masumichi Seta, Nario Kuno, Dragan Salak, Shun Ishii, Makoto Nagai, Naomasa Nakai
Summary: Through [Ci](1-0) mapping observations, this study found that the distribution of atomic carbon is similar to CO lines in the central region of the galaxy, but differs in the arm region. The dust mass density shows better consistency with CO(1-0), indicating that CO(1-0) is a more reliable tracer of cold molecular gas.
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN
(2021)
Article
Astronomy & Astrophysics
Hideaki Takemura, Fumitaka Nakamura, Shun Ishii, Yoshito Shimajiri, Patricio Sanhueza, Takashi Tsukagoshi, Ryohei Kawabe, Tomoya Hirota, Akimasa Kataoka
Summary: A study was conducted on the Orion A Giant Molecular Cloud through an unbiased dense core survey using the (CO)-O-18 emission line. Results showed that the fractional abundance of (CO)-O-18 remains relatively constant with varying column density, but there may be a depletion trend in higher column density regions. By classifying 709 cores as starless cores and analyzing their mass function, it was found that the mass distribution of starless cores resembles the stellar initial mass function.
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN
(2021)
Article
Astronomy & Astrophysics
Yuko Matsushita, Satoko Takahashi, Shun Ishii, Kohji Tomisaka, Paul T. P. Ho, John M. Carpenter, Masahiro N. Machida
Summary: In this study, ALMA observations of the high-velocity jet associated with the FIR 6b protostar in the Orion Molecular Cloud-2 revealed a velocity gradient and rotational characteristics. By combining disk wind theory with the observations, the launching radius of the jet was estimated.
ASTROPHYSICAL JOURNAL
(2021)
Article
Agronomy
Yusuke Imoto, Shoko Yoshikawa, Yuki Horiuchi, Takumi Iida, Taisei Oka, Shuichi Matsuda, Yoshihiko Tokuji, Masahiko Mori, Kiyoaki Kato
Summary: This study identified the VaE1 gene as the responsible gene for the FD1 locus in adzuki bean. The VaE1 gene acts as a floral repressor by being upregulated under long-day conditions. These findings provide insights into the molecular control of flowering time in adzuki bean and offer clues for breeding adzuki bean at higher latitudes.
Article
Optics
Yoshitaka Jin, Tomoaki Nishizawa, Nobuo Sugimoto, Satoru Takakura, Makoto Aoki, Shoken Ishii, Akihiro Yamazaki, Rei Kudo, Keiya Yumimoto, Kaori Sato, Hajime Okamoto
Summary: A simple dual-wavelength high-spectral-resolution lidar was developed for continuous observations of aerosol profiles using a scanning interferometer. The system demonstrated robustness through one month of continuous measurements.
Article
Optics
Shoken Ishii, Kodai Kishibuchi, Hideki Takenaka, Yoshitaka Jin, Tomoaki Nishizawa, Nobuo Sugimoto, Hironari Iwai, Makoto Aoki, Seiji Kawamura, Hajime Okamoto
Summary: A compact and simple 355-nm direct-detection Doppler wind lidar (DDDWL) was developed to measure LOS wind speed of the background atmosphere. The receiver design used a Fabry-Perot etalon interferometer (FPEI) and a double-edge filter. Preliminary experimental evaluation showed that the DDDWL had the potential to measure low LOS wind speeds.
Article
Biochemistry & Molecular Biology
Junya Azumi, Tomoya Takeda, Yasuhiro Shimada, Tao Zhuang, Yoshihiko Tokuji, Naoya Sakamoto, Hisashi Aso, Takashi Nakamura
Summary: This study found that the organogermanium compound Ge-132 and its hydrolysate THGP activate NK cells and macrophages through the induction of IFN-gamma activity, exerting antitumor effects. THGP promotes M1 polarization of macrophages and suppresses the expression of SIRP-alpha in macrophages and CD47 in cancers. Based on these findings, THGP could be a new regulatory reagent for tumor immunity suppression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Meteorology & Atmospheric Sciences
Hironori Iwai, Makoto Aoki, Mitsuru Oshiro, Shoken Ishii
Summary: The study validated wind speed data for different periods and found different biases. Vertical and seasonal analyses were conducted to reveal the variation of systematic errors.
ATMOSPHERIC MEASUREMENT TECHNIQUES
(2021)
Article
Biochemistry & Molecular Biology
Hiroki Maruyama, Atsumi Taguchi, Mariko Mikame, Atsushi Izawa, Naoki Morito, Kazufumi Izaki, Toshiyuki Seto, Akifumi Onishi, Hitoshi Sugiyama, Norio Sakai, Kenji Yamabe, Yukio Yokoyama, Satoshi Yamashita, Hiroshi Satoh, Shigeru Toyoda, Michihiro Hosojima, Yumi Ito, Ryushi Tazawa, Satoshi Ishii
Summary: Plasma globotriaosylsphingosine and GLA activity, as combined screening markers, are effective in identifying Fabry disease patients. By screening patients with clinical findings suggestive of Fabry disease and incorporating GLA activity and GLA variant status, it can serve as primary screening biomarkers for classic, late-onset, and late-onset biopsy-proven Fabry disease probands.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
