Article
Biochemical Research Methods
Angela Gilda Carota, Beatrice Campanella, Renata Del Carratore, Paolo Bongioanni, Roberta Giannelli, Stefano Legnaioli
Summary: This study analyzed blood serum samples using Raman spectroscopy to develop a classification model for the diagnosis of Alzheimer's type dementia. Lower levels of carotenoids were detected in patients' blood serum compared to controls, and these levels may provide information about the severity and progression of the disease. The results suggest the possibility of using Raman spectroscopy for the non-invasive diagnosis of neurodegenerative disorders.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Youssef El Khoury, Alicia Schirer, Christine Patte-Mensah, Christian Klein, Laurence Meyer, Monika Rataj-Baniowska, Sophie Bernad, David Moss, Sophie Lecomte, Ayikoe-Guy Mensah-Nyagan, Petra Hellwig
Summary: The study found accumulation of hemes in senile plaques in both murine and human samples of Alzheimer's disease, but was unable to identify the specific type of heme accumulating in the plaques.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Stanislav Rizevsky, Mikhail Matveyenka, Dmitry Kurouski
Summary: Lipids can modify the structure of amyloid-associated proteins and affect their rates of aggregation. Atomic force microscopy infrared spectroscopy was used to study the structure of insulin oligomers and observed strong interactions between lipids and proteins during the oligomer formation.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Clinical Neurology
Christina Rabe, Tobias Bittner, Alexander Jethwa, Ivonne Suridjan, Ekaterina Manuilova, Michel Friesenhahn, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Summary: This study evaluated the clinical performance and robustness of plasma Aβ(42)/Aβ(40) as a prescreening tool for Alzheimer's disease. It found that there were misclassifications caused by measurement errors and pre-analytical errors, and suggested that other blood biomarkers may be easier to implement as robust prescreening tools.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Daniel L. D. Freitas, Ana F. S. Peres, Lidiane G. Silva, Joao V. M. Mariz, Marcos G. Santos, Rayanne S. P. Morais, Camilo L. M. Morais, Francis L. Martin, Daniel A. Pascoal, Juliana D. de A. S. Camargo, Janaina C. O. Crispim, Kassio M. G. Lima
Summary: The prevention of mother-to-child transmission programs in Brazil have seen success, as access to antiretroviral therapy during pregnancy has led to a reduction in new infections among children. By utilizing near-infrared spectroscopy, pregnant women with and without HIV infection can be quickly and accurately differentiated, offering a new perspective on investigating vertical transmission and providing a potential low-cost screening tool for fast HIV detection.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Xiang Zou, Yujun Liao, Conglin Jiang, Yifan Yuan, Fan Zhao, Ding Ding, Liang Chen, Bin Xu, Ying Mao
Summary: By studying the correlation between cerebral blood flow and cognitive decline, as well as plasma AD biomarkers, it was found that reduced blood flow is associated with cognitive decline and AD pathology burden.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Analytical
Diletta Ami, Alessandro Duse, Paolo Mereghetti, Federica Cozza, Francesca Ambrosio, Erika Ponzini, Rita Grandori, Christian Lunetta, Silvia Tavazzi, Fabio Pezzoli, Antonino Natalello
Summary: Optical spectroscopy techniques applied to human tears offer a non-invasive and label-free method for detecting ALS with high specificity and sensitivity. Investigation of tears reveals spectroscopic markers related to ALS, making tears a reliable source of biomarkers for the disease.
ANALYTICAL CHEMISTRY
(2021)
Article
Neurosciences
Anna Lidia Wojdala, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Summary: The transition from cerebrospinal fluid (CSF) to plasma provides new avenues for studying molecular phenotypes of Alzheimer's disease (AD). This study evaluated a panel of AD biomarkers in matched CSF and plasma samples, comparing their diagnostic performance and evaluating their trajectories along the AD progression. The findings suggest that a standardized panel of selected plasma markers can facilitate early AD diagnosis and monitoring of disease progression.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Shorena Janelidze, Divya Bali, Nicholas J. Ashton, Nicolas R. Barthelemy, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Yingxin He, Anna Orduna Dolado, Gallen Triana-Baltzer, Michael J. Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck, Kaj Blennow, Randall J. Bateman, Oskar Hansson
Summary: Plasma phospho-tau species, especially p-tau217, show promise as blood-based biomarkers for Alzheimer's disease. This study compared the performance of different assays for p-tau181, p-tau217, and p-tau231 in detecting abnormal A beta status and predicting progression to Alzheimer's dementia. The mass spectrometry-based p-tau217 (p-tau217(WashU)) demonstrated the best performance, while several immunoassays, including p-tau217(Lilly), p-tau217(Janss), p-tau181(ADx), and p-tau181(WashU), showed high accuracy in both outcomes.
Article
Spectroscopy
Manman Lin, Haisheng Ou, Peng Zhang, Yanhong Meng, Shenghao Wang, Jing Chang, Aiguo Shen, Jiming Hu
Summary: Alzheimer's disease is a common and threatening nervous system disease for the elderly. Traditional diagnostic methods are not accurate enough, so a new diagnostic method combining laser tweezers Raman spectroscopy and machine learning algorithms has been proposed, which can effectively diagnose Alzheimer's disease in the early, middle, and advanced stages.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Ondrej Vrtelka, Katerina Kralova, Marketa Fouskova, Lucie Habartova, Petr Hribek, Petr Urbanek, Vladimir Setnicka
Summary: More than one fifth of the world's population is affected by liver cirrhosis or other chronic liver diseases, leading to the inevitable occurrence of hepatocellular carcinoma (HCC) in some cases. However, lack of early diagnostic options results in HCC mortality being on par with its incidence. Unlike other types of cancer, the incidence of HCC is expected to increase in the future, emphasizing the need for an effective early diagnostic option. This study suggests that blood plasma analysis using a combination of chiroptical and vibrational spectroscopic methods could be the key to improving current diagnostic capabilities.
Review
Biochemistry & Molecular Biology
Chen Yu, Bing Zhao, Yan Li, Hengchang Zang, Lian Li
Summary: This review discusses the current research status of osteoarthritis (OA), the importance of early diagnosis, the potential application of vibrational spectroscopy in OA diagnosis, comparison of various diagnostic methods, and the promising role of vibrational spectroscopy as a tool for early OA diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Spectroscopy
Katerina Kralova, Ondrej Vrtelka, Marketa Fouskova, Petr Hribek, Bohus Bunganic, Michaela Miskovicova, Petr Urbanek, Miroslav Zavoral, Lubos Petruzelka, Lucie Habartova, Vladimir Setnicka
Summary: Improving early diagnosis of gastrointestinal cancers is crucial for reducing mortality. The non-specific symptoms pose a challenge in differentiating between different types of gastrointestinal cancers. By using Raman spectroscopy and Raman optical activity to analyze blood plasma samples, the study aimed to identify disease-specific alterations in biomolecular structure and composition. The statistical methods tested showed high accuracy in discriminating between cancer and control samples, as well as differentiating among the three studied cancer types.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Clinical Neurology
Antoinette O'Connor, Josef Pannee, Teresa Poole, Charles Arber, Erik Portelius, Imogen J. Swift, Amanda J. Heslegrave, Emily Abel, Nanet Willumsen, Helen Rice, Philip S. J. Weston, Natalie S. Ryan, James M. Polke, Jennifer M. Nicholas, Simon Mead, Selina Wray, Lucia Chavez-Gutierrez, Chris Frost, Kaj Blennow, Henrik Zetterberg, Nick C. Fox
Summary: In this study, differences in amyloid-beta processing between PSEN1 and APP carriers were identified, providing insights into disease pathophysiology and potential implications for therapy development. The analysis of plasma and cell line models demonstrated consistent amyloid-B profiles, with associations found between A beta 42:38, AB42:40, and A beta 38:40 ratios and parental age at onset in the PSEN1 group.
Article
Chemistry, Analytical
Arghya Banerjee, Abhiram Gokhale, Renuka Bankar, Viswanthram Palanivel, Akanksha Salkar, Harley Robinson, Jayanthi S. Shastri, Sachee Agrawal, Gunter Hartel, Michelle M. Hill, Sanjeeva Srivastava
Summary: This study demonstrates the potential of attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy as a rapid, low-cost COVID-19 severity triage tool to facilitate COVID-19 patient management during an outbreak. By incorporating ATR-FTIR spectra into clinical parameters, the classification accuracy of COVID-19 disease severity was significantly improved, showing promise for future applications in hospital settings.
ANALYTICAL CHEMISTRY
(2021)
