期刊
BIORESOURCE TECHNOLOGY
卷 170, 期 -, 页码 356-360出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2014.07.098
关键词
Arachidonic acid; Lipid; Mortierella alpina; Productivity; Repeated fed-batch
资金
- National Science Foundation for Distinguished Young Scholars of China [21225626]
- National Basic Research Program of China [2011CBA00800]
- National Natural Science Foundation of China [21376002]
- Jiangsu Provincial Natural Science Foundation of China [BK20131405]
- National High-Tech R&D Program of China [2014AA021703]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Fok Ying-Tung Education Foundation [143051]
- QINLAN Project of Jiangsu Province
Arachidonic acid (ARA)-rich oil production by Mortierella alpina is a long fermentation period needed process due to the low growth rate of the filamentous fungus used. This causes the low productivity of ARA-rich oil and hinders its industrial mass scale production. In the present study, different fed-batch strategies were conducted to shorten the fermentation period. The result showed that compared with the batch culture, the fermentation period was shortened from 7 days to 5 days with the productivity of ARA-rich oil increased from 0.9 g/(L.d) to 1.3 g/(L.d) by using the fed-batch fermentation strategy. Furthermore, repeated fed-batch fermentation strategy was adopted to achieve the purpose of continuous production. By using this strategy, the fermentation period was shortened from 40 days to 26 days in a four cycle repeated fed-batch fermentation. This strategy proved to be convenient and economical for ARA-rich oil commercial production process. (C) 2014 Elsevier Ltd. All rights reserved.
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