Review
Respiratory System
Sujeet K. Rajan, Vincent Cottin, Raja Dhar, Sonye Danoff, Kevin R. Flaherty, Kevin K. Brown, Anant Mohan, Elizabeth Renzoni, Murali Mohan, Zarir Udwadia, Padmanabha Shenoy, David Currow, Anand Devraj, Bhavin Jankharia, Ritu Kulshrestha, Steve Jones, Claudia Ravaglia, Silvia Quadrelli, Rajam Iyer, Sahajal Dhooria, Martin Kolb, Athol U. Wells
Summary: This expert group consensus statement highlights the importance of standardizing the definition of progressive fibrosing interstitial lung diseases (F-ILDs) and the need for accurate initial diagnosis. Case-by-case decisions on monitoring and management are essential due to the varying presentations and rates of progression. The guidance also emphasizes the value of diagnostic tests in risk stratification and the use of early antifibrotic therapy in progressive pulmonary fibrosis (PPF).
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Dermatology
T. Meyer-Gonzalez, D. Bacqueville, R. Grimalt, V. Mengeaud, B. M. Piraccini, L. Rudnicka, D. Saceda-Corralo, A. Vogt, S. Vano-Galvan
Summary: This study aimed to gather information and achieve consensus on the latest advances in alopecia, trichoscopy, and hair dermocosmetics. Through a two-round Delphi procedure among 45 European dermatologists, consensus was reached on all recommendations, providing guidance for clinical practice. Additionally, the participants highlighted the need for further clinical studies to assess the benefits of emerging tools and treatments in improving patients' quality of life.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Konstantinos Dimopoulos, Andrew Constantine, Paul Clift, Robin Condliffe, Shahin Moledina, Katrijn Jansen, Ryo Inuzuka, Gruschen R. Veldtman, Clifford L. Cua, Edgar Lik Wui Tay, Alexander R. Opotowsky, George Giannakoulas, Rafael Alonso-Gonzalez, Rachael Cordina, George Capone, Judith Namuyonga, Charmaine H. Scott, Michele D'Alto, Francisco J. Gamero, Brian Chicoine, Hong Gu, Alisa Limsuwan, Tosin Majekodunmi, Werner Budts, Gerry Coghlan, Craig S. Broberg
Summary: Congenital heart disease is the most common cardiovascular condition in individuals with Down syndrome, affecting up to 50% of patients. Other factors that contribute to cardiovascular outcomes include pulmonary hypertension, pulmonary, endocrine, and metabolic diseases, and risk factors for atherosclerotic disease. Disparities in cardiovascular care for individuals with Down syndrome, which vary across different locations and healthcare systems, are often overlooked. This review provides a comprehensive summary of the diagnosis, prevalence, and management of cardiovascular disease in patients with Down syndrome, as well as addressing disparities in care based on resource availability.
Article
Pharmacology & Pharmacy
Annemieke Aartsma-Rus, Marc Dooms, Yann Le Cam
Summary: The OD Expert Group was established in 2020 to develop policy proposals to improve orphan medicinal product (OMP) development in Europe. The group consists of representatives from the rare disease community and aims to address the lack of existing treatments through a multi-stakeholder approach.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Alessia Paglialonga, Raffaella Gaetano, Leema Robert, Marine Hurard, Luisa Maria Botella, Natasha Barr, Guillaume Jondeau, Alessandro Pini
Summary: The eHealth Working Group of VASCERN aims to develop patient-centered solutions and strategies for the effective use of eHealth tools in addressing the needs of patients with multisystemic vascular rare diseases. The group has developed a mobile app to help patients locate expert centers and patient organizations, as well as resources for training and education via digital platforms. The work of the eHealth WG can serve as a pilot experience for the collaborative development of patient-centered eHealth tools for rare diseases across Europe.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Urology & Nephrology
Emma O'Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig, Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaue, Andrea K. Viecelli, Angela Y. Wang, David C. Wheele, David White, Wolfgang C. Winkelmayer, Charles A. Herzog
Summary: Cardiovascular disease is the leading cause of death in hemodialysis patients. However, there is currently no standardized definition of myocardial infarction (MI) for this population. The international working group recommends specific approaches for interpreting ischemic symptoms and performing baseline electrocardiograms to improve the accuracy of MI diagnosis in hemodialysis patients. While baseline cardiac troponin values are not recommended, serial cardiac biomarkers should be obtained when ischemia is suspected.
KIDNEY INTERNATIONAL
(2023)
Article
Respiratory System
Franck F. Rahaghi, Vivien M. Hsu, Robert J. Kaner, Maureen D. Mayes, Ivan O. Rosas, Rajan Saggar, Virginia D. Steen, Mary E. Strek, Elana J. Bernstein, Nitin Bhatt, Flavia V. Castelino, Lorinda Chung, Robyn T. Domsic, Kevin R. Flaherty, Nishant Gupta, Bashar Kahaleh, Fernando J. Martinez, Lee E. Morrow, Teng Moua, Nina Patel, Oksana A. Shlobin, Brian D. Southern, Elizabeth R. Volkmann, Dinesh Khanna
Summary: This study aimed to develop consensus recommendations on the management of patients with SSc-ILD based on expert physician insights. A modified Delphi process was completed by pulmonologists and rheumatologists, resulting in the generation of a management algorithm that addresses the current gaps in management approaches.
RESPIRATORY RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephane Kremer, Simonetta Gerevini, Ana Ramos, Francois Lersy, Tarek Yousry, Meike W. Vernooij, Nicoletta Anzalone, Hans Rolf Jager
Summary: Neurological and neuroradiological manifestations in patients with COVID-19 have been extensively reported, but there is a need to standardize imaging protocols and follow-up examinations. The NeuroCovid working group aims to address this by providing expert opinion and recommendations to improve patient care quality and future clinical studies.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
David Chi-Leung Lam, Chong-Kin Liam, Sita Andarini, Samina Park, Daniel S. W. Tan, Navneet Singh, Seung Hun Jang, Varut Vardhanabhuti, Antonio B. Ramos, Tomio Nakayama, Nguyen Viet Nhung, Kazuto Ashizawa, Yeun-Chung Chang, Jamsak Tscheikuna, Cong Cung Van, Wai Yee Chan, Yeur-Hur Lai, Pan-Chyr Yang
Summary: The incidence and mortality of lung cancer are highest in Asia compared to Europe and USA. In some areas in Asia, there is limited availability of robust diagnostic tools and treatment modalities, making it necessary to have a more specific approach for screening and early detection of lung cancer.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Mikel Izquierdo, R. A. Merchant, J. E. Morley, S. D. Anker, I. Aprahamian, H. Arai, M. Aubertin-Leheudre, R. Bernabei, E. L. Cadore, M. Cesari, L. -k. Chen, P. de Souto Barreto, G. Duque, L. Ferrucci, R. A. Fielding, A. Garcia-Hermoso, L. M. Gutierrez-Robledo, S. D. R. Harridge, B. Kirk, S. Kritchevsky, F. Landi, N. Lazarus, F. C. Martin, E. Marzetti, M. Pahor, R. Ramirez-Velez, L. Rodriguez-Manas, Y. Rolland, J. G. Ruiz, O. Theou, D. T. Villareal, D. L. Waters, C. Won Won, J. Woo, B. Vellas, M. Fiatarone Singh
Summary: The ageing process is inevitable, but can be slowed down through exercise. Exercise and physical activity play a crucial role in preventing chronic diseases, improving quality of life, and reducing mortality among older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Genetics & Heredity
N. Zozaya, J. Villaseca, F. Abdalla, A. Ancochea, I. Malaga, M. Trapero-Bertran, N. Martin-Sobrino, O. Delgado, P. Ferre, A. Hidalgo-Vega
Summary: The FINEERR project aimed to discuss the funding and access challenges faced by RD-targeted therapies in Spain. Through multidisciplinary discussions involving 40 experts, 50 proposals were defined and the most feasible and important ones included improving patient referral processes, monitoring mechanisms, and communication between healthcare professionals and patients.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Review
Endocrinology & Metabolism
Stephanie Lucas, Michaela Tencerova, Benoit von der Weid, Thomas Levin Andersen, Camille Attane, Friederike Behler-Janbeck, William P. Cawthorn, Kaisa K. Ivaska, Olaia Naveiras, Izabela Podgorski, Michaela R. Reagan, Bram C. J. van der Eerden
Summary: In the past two decades, there has been increased interest in studying bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology, leading to the establishment of the International Bone Marrow Adiposity Society (BMAS) Biobanking Working Group. The group aims to address the challenges of biobanking human BMA-related samples and develop guidelines for creating biobanks for BMA research. Harmonizing isolation protocols and patient information globally is believed to enhance international collaborations and improve the quality of BMA research outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Stephan Gerdes, Sebastian F. Schoppmann, Luigi Bonavina, Nicholas Boyle, Beat P. Mueller-Stich, Christian A. Gutschow, Suzanne Sarah Gisbertz, Ferdinand Kockerling, Thorsten G. Lehmann, Dietmar Lorenz, Frank Alexander Granderath, Riccardo Rosati, Christoph Wullstein, Lars Lundell, Edward Cheong, Philippe Nafteux, Stefano Olmi, Stefan Monig, Matthias Biebl, Jessica Leers, Joerg Zehetner, Ivan Kristo, Richard George Berrisford, Ognjan M. Skrobic, Aleksandar P. Simic, Manuel Pera, Peter Philipp Grimminger, Ines Gockel, Konstantinos Zarras, Vincent Bernard Nieuwenhuijs, James A. Gossage, Mark I. van Berge Henegouwen, Hubert J. Stein, Sheraz R. Markar, Willem Eduard Hueting, Eduardo M. Targarona, Jan Johansson, Graeme D. Macaulay, Bas P. L. Wijnhoven, Frank Benedix, Stephen E. Attwood, Arnulf Heinrich Hoelscher, Pablo Priego, Karl-Hermann Fuchs, Misha D. P. Luyer, Ewen A. Griffiths, Torgeir Thorson Sovik, Dimitrios Theodorou, Bruno Sgromo, Jarmo A. Salo, Rishi Singhal, Anders Thorell, Giovanni Zaninotto, Marko Itenc, Xavier Benoit D'journo, Grant M. Fullarton, Thomas Horbach
Summary: This survey aims to identify optimal management strategies for patients with paraesophageal hiatus hernia through a Delphi methodology. European surgeons with expertise in upper-GI participated in a two-round survey, providing recommendations on preoperative work-up, surgical procedure, and postoperative follow-up. The survey results delineate recommended and discouraged strategies for various aspects of the management of paraesophageal hiatus hernia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Dentistry, Oral Surgery & Medicine
David Herrera, Mariano Sanz, Lior Shapira, Carlos Brotons, Iain Chapple, Thomas Frese, Filippo Graziani, F. D. Richard Hobbs, Olivier Huck, Eva Hummers, Soren Jepsen, Oleg Kravtchenko, Phoebus Madianos, Ana Molina, Mehmet Ungan, Josep Vilaseca, Adam Windak, Shlomo Vinker
Summary: This study explores the implications for dentists and family doctors in the association between periodontal and systemic diseases and their roles in managing non-communicable diseases (NCDs) and promoting healthy lifestyles. The results show that periodontitis is independently associated with cardiovascular diseases, diabetes, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea, and COVID-19 complications. Dentists and family doctors should collaborate in managing NCDs and implementing strategies for early detection of periodontitis and cardiovascular diseases or diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Multidisciplinary Sciences
Huisheng Ai, Nelson J. Chao, David A. Rizzieri, Xiaojun Huang, Thomas R. Spitzer, Jianxiang Wang, Mei Guo, Armand Keating, Elizabeth F. Krakow, Didier Blaise, Jun Ma, Depei Wu, John Reagan, Usama Gergis, Rafael F. Duarte, Preet M. Chaudhary, Kaixun Hu, Changlin Yu, Qiyun Sun, Ephraim Fuchs, Bo Cai, Yajing Huang, Jianhui Qiao, David Gottlieb, Kirk R. Schultz, Mingyao Liu, Xiequn Chen, Wenming Chen, Jianmin Wang, Xiaohui Zhang, Jianyong Li, He Huang, Zimin Sun, Fei Li, Linhua Yang, Liansheng Zhang, Lijuan Li, Kaiyan Liu, Jie Jin, Qifa Liu, Daihong Liu, Chunji Gao, Chuanbo Fan, Li Wei, Xi Zhang, Liangding Hu, Weijing Zhang, Yuyang Tian, Weidong Han, Jun Zhu, Zhijian Xiao, Daobin Zhou, Bolong Zhang, Yongqian Jia, Yongqing Zhang, Xiaoxiong Wu, Xuliang Shen, Xuzhang Lu, Xinrong Zhan, Xiuli Sun, Yi Xiao, Jingbo Wang, Xiaodong Shi, Bo Zheng, Jieping Chen, Banghe Ding, Zhao Wang, Fan Zhou, Mei Zhang, Yizhuo Zhang, Jie Sun, Bing Xia, Baoan Chen, Liangming Ma
Summary: Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022. The recommendations address key issues including therapeutic principle, candidate selection, chemotherapy regimens, post-remission therapy, and other aspects such as donor screening and complications.
