Article
Chemistry, Multidisciplinary
Ke He, Pingqiang Cai, Shaobo Ji, Zihan Tang, Zhou Fang, Wenlong Li, Jing Yu, Jiangtao Su, Yifei Luo, Feilong Zhang, Ting Wang, Ming Wang, Changjin Wan, Liang Pan, Baohua Ji, Dechang Li, Xiaodong Chen
Summary: Hydrogels are crucial for on-skin healthcare devices, but their dehydration is a limiting factor. This study presents an antidehydration hydrogel with superior hydrating zwitterionic oligomers. It excels in preventing dehydration and skin penetration, while ensuring stable signal acquisition under low-humidity conditions. It holds potential for epidermis-safe on-skin devices.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
James A. Hokanson, Christopher L. Langdale, Arun Sridhar, Phil Milliken, Warren M. Grill
Summary: State-dependent electrical stimulation can increase both bladder capacity and voiding efficiency by using different parameters during bladder filling and emptying, compared to continuous stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yanxiu Cui, Tong Zhao, Huichao Wang, Xiaolong Wang, Daohan Wang, Yuantao Zhang
Summary: This study established a model of oxidized phospholipids and simulated the transmembrane process of reactive species under the conditions of oxidation and an electric field using the classical molecular dynamics (MD) method. The results showed that electroporation provided a new channel for reactive species to penetrate the membrane, and the oxidation effect reduced the electric field threshold of membrane electroporation. This research provides theoretical support for understanding the mechanism of plasma-induced apoptosis of cancer cells and guidance for the practical application of plasma-induced cancer therapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Stuart T. Johnston, Matthew Faria
Summary: Designing nano-engineered particles for targeted delivery of therapeutic and diagnostic agents is a challenging task. This study presents a machine learning framework that can interpret particle-cell interactions from experimental data, providing insights into the design choices. The framework reveals consistent models of particle-cell interactions for different particle-cell pairs, highlighting the importance of nonlinear saturation effects. Additionally, the framework facilitates quantitative evaluation of particle design choices by providing robust estimates of particle performance.
Article
Chemistry, Multidisciplinary
Yun Zhang, Duo Chen, Wang He, Na Chen, Liping Zhou, Lilei Yu, Yanbing Yang, Quan Yuan
Summary: This article summarizes the significant advancements in FET biosensors over the past decade, focusing on interface engineering and biomolecule identification in FET electronic platforms. It comprehensively reviews the applications of FET electronic devices for in vitro detection and real-time monitoring in biological systems, and discusses the key opportunities and challenges in biosensing. The understanding of interface engineering strategies in FET biosensors is expected to inspire the development of highly sensitive, specific, and stable FET biosensors, as well as emerging designs for next-generation biosensing electronics.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Miusi Shi, Kailun Shen, Bin Yang, Peng Zhang, Kangle Lv, Haoning Qi, Yunxiao Wang, Mei Li, Quan Yuan, Yufeng Zhang
Summary: The study introduces an electroporation-based membrane coating strategy to synthesize MNPs for treating bone infection, demonstrating improved efficiency in recognition and adsorption of pathogens due to enhanced functional proteins. The MNPs show significant antibacterial and anti-inflammatory abilities, promoting tissue repair and showing potential for future bioengineering applications.
Article
Polymer Science
Asmaul Husna, Iqubal Hossain, Insu Jeong, Tae-Hyun Kim
Summary: Mixed matrix membranes (MMMs) have overcome the limitations of traditional polymeric membranes for gas separation by improving both permeability and selectivity. This study successfully achieved compatibility between polymers and metal-organic frameworks (MOFs) in MMMs through conjugation modification, improving the efficiency and performance of gas separation.
Article
Chemistry, Analytical
Yuki Watanabe, Hirohito Nihonyanagi, Rika Numano, Takayuki Shibata, Kazunori Takashima, Hirofumi Kurita
Summary: In this study, the influence of the electroporation medium on membrane permeabilization stimulated by electrical short-circuiting was investigated. It was found that the conductivity of the external medium had a significant impact on the experimental results, and low-conductivity electroporation medium enhanced the formation of membrane pores.
Article
Materials Science, Multidisciplinary
Jian-Wei Guo, Jian-Long Wang, Shang-kun Jiang, Li Li
Summary: This study establishes a stable measuring system using water media, metal electrode, and Nafion membrane as an equivalent circuit. The effectiveness of the equivalent circuit is validated using cyclic voltammetry and electrochemical impedance spectroscopy. This breakthrough in electrochemistry enables reliable measurements even under successive temperature cycles and provides circuit elements for kinetic analysis. The results have broad implications for various applications in fuel cells, batteries, and materials.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Han Jo Jeon, Hong Bae Kim, Sun Young Yim, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Bora Keum
Summary: This study explores the synergistic application of near-infrared irradiation and irreversible electroporation (IRE), finding that this combination treatment enhances tissue electrical properties and increases apoptosis. Compared to IRE alone, the combined treatment of near-infrared irradiation and IRE shows improved therapeutic efficacy.
APPLIED SCIENCES-BASEL
(2023)
Review
Cell Biology
Suzan Kors, Joseph L. Costello, Michael Schrader
Summary: VAP proteins play crucial roles in various cellular processes such as organelle membrane tethering and lipid transfer. Viruses and intracellular bacteria can exploit VAPs to induce interactions between host ER and pathogen-containing compartments, supporting pathogen replication.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Susav Pradhan, Martin A. K. Williams, Tracy K. Hale
Summary: In this study, the mechanical properties of HP1 alpha-depleted MCF7 breast cancer cells were explored by pulling membrane tethers using optical tweezers in comparison to controls. The results showed significant differences in membrane tension and mechanical properties between HP1 alpha-depleted breast cancer cells and their matched controls.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Hongfei Liu, Jiangzhou Qin, Jincheng Mu, Baojun Liu
Summary: In this study, cobalt nanoparticles decorated nitrogen-doped carbon catalysts were prepared by in situ interface engineering for the selective synthesis of ammonia. The catalyst exhibited remarkable performance and excellent cycle stability, achieving a high ammonia yield of 1352.5 lg h-1 mgcat-1 at-1.7 V vs Ag/AgCl, with a high ammonia selectivity of 98.2% and a maximum Faradic efficiency of 81.2% at-1.2 V vs Ag/AgCl. DFT calculation results suggested that the interfacial effect between cobalt nanoparticles and nitrogen-doped carbon enhanced electron transfer and promoted the production of ammonia by lowering the adsorption and conversion free energy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Cell Biology
Aya O. Satoh, Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Mari Fujioka, Hitoshi Sasajima, Asuka Nanbo, Maho Amano, Yusuke Ohba
Summary: This article investigates the communication between intracellular organelles of mammalian cells during cellular processes, focusing on the binding of VDAC2 and PI3K in regulating clathrin-independent endocytosis and endosome maturation.
Article
Biochemical Research Methods
Violeta L. Calin, Mona Mihailescu, Nicolae Tarba, Ana Maria Sandu, Eugen Scarlat, Mihaela G. Moisescu, Tudor Savopol
Summary: Cell electroporation is a method where the plasma membrane is controlled permeabilized by electric pulses, allowing for drug delivery, gene transfer, and cell fusion. The dynamics of cellular response to electric pulses is still not fully explored, but phase-derived parameters and autocorrelation functions can be used to analyze cell membrane reorganization.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Chemistry, Analytical
Darshil Patel, R. Verena Taudte, Katie Nizio, George Herok, Charles Cranfield, Ronald Shimmon
Summary: This study focused on detecting the multiple complex compounds classes produced by the pyrolysis of E-cigarette liquids using comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. The results showed that heating E-liquids emits over 1000 volatile compounds, of which over 150 are toxic. The application of this technique allows a better understanding of the potential health effects of vaping.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Endocrinology & Metabolism
Sing-Young Chen, Martina Beretta, Stephanie J. Alexopoulos, Divya P. Shah, Ellen M. Olzomer, Stefan R. Hargett, Elizabeth S. Childress, Joseph M. Salamoun, Isabella Aleksovska, Ariane Roseblade, Charles Cranfield, Tristan Rawling, Kate G. R. Quinlan, Margaret J. Morris, Simon P. Tucker, Webster L. Santos, Kyle L. Hoehn
Summary: SHC517, a small molecule mitochondrial uncoupler, has potent anti-obesity and insulin sensitizing effects in mice. It prevents and reverses diet-induced obesity, improves glucose tolerance, and fasting glucose levels without affecting food intake or lean body mass. These effects make it a promising candidate for anti-obesity therapeutics.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Editorial Material
Biophysics
Charles Cranfield, Donna Whelan, Charles Cox, Keith Shearwin, Joshua Ho, Toby Allen, Risa Shibuya, Emi Hibino, Kumiko Hayashi, Cristobal dos Remedios, Amy Li
Summary: This Commentary calls for submissions for an upcoming Special Issue focusing on research topics presented at the Australian Society of Biophysics (ASB) in 2020 and 2021. Submissions from past and present ASB members who could not attend these meetings are also encouraged.
BIOPHYSICAL REVIEWS
(2021)
Editorial Material
Biophysics
Cristobal dos Remedios, Charles Cranfield, Donna Whelan, Charles Cox, Keith Shearwin, Joshua Ho, Toby Allen, Risa Shibuya, Emi Hibino, Kumiko Hayashi, Amy Li
Summary: The Australian Society for Biophysics is a cooperative academic organization with the Asia-Pacific region. Although it is smaller in size compared to its counterparts in Japan and the United States, it is dedicated to supporting the development of emerging biophysicists. They have established a partnership with colleagues in New Zealand and hold joint sessions with the Biophysical Society for Japan.
BIOPHYSICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jie Wu, Tsz Tin Yu, Rajesh Kuppusamy, Md Musfizur Hassan, Amani Alghalayini, Charles G. Cranfield, Mark D. P. Willcox, David StC Black, Naresh Kumar
Summary: There is an urgent need for the development of new antibacterial agents to combat antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics show promise as potential new drugs for treating bacterial infections. Structure-activity relationship studies indicate that tryptophan moiety and a minimum of +2 charge are important for high antibacterial activity. Analogs containing lysine-like residues exhibit the highest antibacterial potency against Gram-positive S. aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Edward York, Daniel A. McNaughton, Ariane Roseblade, Charles G. Cranfield, Philip A. Gale, Tristan Rawling
Summary: This paper investigates the mechanism of how the anticancer agent SR4 uncouples mitochondria and develops a library of substituted bisaryl ureas for further studies. The research shows that SR4 uncouples mitochondria through the fatty acid-activated mechanism and identifies a compound that reduces cell viability more effectively than SR4.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D. P. Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, DongKuk Lee, Nirakar Sahoo, Charles G. Cranfield, Sanhita Roy, Anirban Bhunia
Summary: This paper presents the mode of action and efficacy of the VR18 peptide against Pseudomonas, providing a new therapeutic approach for the prevention and treatment of Pseudomonas-associated microbial keratitis.
BIOPHYSICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Emma-Lucille Blayney, Milna Chennath, Charles G. Cranfield, Ronald J. Clarke
Summary: The Na+, K+-ATPase is an integral membrane protein that uses ATP hydrolysis to transport Na+ and K+ ions across the plasma membrane. It has essential roles in various physiological processes and is regulated through phosphorylation by protein kinase C (PKC) and Src kinase families. The study used the mirror tree method to analyze the coevolution between these kinases and Na+, K+-ATPase. The results suggested that the theta and eta isoforms of PKC and Src kinase are the most likely to interact with Na+, K+-ATPase. These findings will guide future experimental studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Hugo MacDermott-Opeskin, Callum Clarke, Xin Wu, Ariane Roseblade, Edward York, Ethan Pacchini, Ritik Roy, Charles Cranfield, Philip A. Gale, Megan L. O'Mara, Michael Murray, Tristan Rawling
Summary: Aryl-carbamate substituted fatty acids can act as protonophores and mitochondrial uncouplers by replacing the urea group, inhibiting ATP production by collapsing the mitochondrial proton gradient.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Michael Chhor, Esra Tulpar, Tara Nguyen, Charles G. Cranfield, Catherine A. Gorrie, Yik Lung Chan, Hui Chen, Brian G. Oliver, Lana McClements, Kristine C. McGrath
Summary: Cardiovascular disease (CVD) is a leading cause of death globally, with smoking being a major risk factor. Quitting smoking is challenging due to nicotine addiction and withdrawal symptoms. Electronic cigarettes (e-Cigs) have emerged as an alternative, but their cardiovascular effects are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Upeksha Mirissa Lankage, Stephen A. Holt, Samara Bridge, Bruce Cornell, Charles G. Cranfield
Summary: This study introduces a sparsely tethered triglyceride substrate for the impedance sensing of lipase activity in real time. The substrate can form an anchored bilayer off the gold electrode, allowing for ion transport through membrane defects caused by enzymatic hydrolysis. The rapid and reliable detection method has potential applications in disease studies, monitoring of lipase production, and point-of-care diagnostics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Meeting Abstract
Biophysics
Ronald J. Clarke, Bogdan Lev, Milna Chennath, Toby W. Allen, Charles G. Cranfield, Emma-Lucille Blayney, Flemming Cornelius
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Physical
Lauren A. Lowe, James T. Kindt, Charles Cranfield, Bruce Cornell, Alexander Macmillan, Anna Wang
Summary: The study reveals that the rupture tension and permeability of fatty acid bilayers to water and ions are coupled to pH via alterations to lipid packing. Experimental and molecular dynamics simulations show that a subtle increase in pH can lead to increased water penetration, ion permeability, pore formation rates, and membrane disorder. The findings have implications for various systems where fatty acids are present, such as primitive cells on early Earth and biological membranes during digestion.
Meeting Abstract
Biophysics
Evelyne Deplazes, Beatriu Domingo Tafalla, Christopher Murphy, Jacqueline White, Charles G. Cranfield, Alvaro Garcia
BIOPHYSICAL JOURNAL
(2021)
Meeting Abstract
Biophysics
Evelyne Deplazes, Lissy M. Hartmann, Charles G. Cranfield, Alvaro Garcia
BIOPHYSICAL JOURNAL
(2021)