Article
Multidisciplinary Sciences
Stephan Krohn, Nina von Schwanenflug, Leonhard Waschke, Amy Romanello, Martin Gell, Douglas D. Garrett, Carsten Finke
Summary: The brain's large-scale functional networks are driven by temporally correlated activity across brain regions. This study reveals that the brain's network architecture is tightly linked to episodes of neural regularity, characterized by drops in complexity in functional magnetic resonance imaging signals. These drops in complexity explain functional connectivity strength, promote neural activity patterns, and reflect interindividual differences in age and behavior. Furthermore, they shape the connectivity strength, topological configuration, and hierarchy of brain networks, providing a comprehensive explanation for the structure-function relationships within the brain.
Article
Multidisciplinary Sciences
Mi Ke, Xiao Yuan, An He, Peiyuan Yu, Wendong Chen, Yu Shi, Tony Hunter, Peng Zou, Ruijun Tian
Summary: By developing more selective proximity labeling probes and combining them with label-free quantitative proteomics, the study enables exploration of cytosolic protein assemblies, such as phosphotyrosine-mediated protein complexes formed in response to minute-scale EGF stimulation. The authors demonstrate the application of this method in profiling the spatiotemporal interactome of the EGFR signaling component STS1.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Jinyoung Park, Hyeong Yong Song, Subi Choi, Suk-kyun Ahn, Kyu Hyun, Chae Bin Kim
Summary: Increasing global environmental concerns have led to a greater demand for recyclable polymers and efficient recycling practices. However, the lack of melt-processability in thermosets hinders their recycling. This study presents an approach to convert thermosets into processable vitrimers by incorporating a heat-stable photo-active catalyst. The catalytic reactions are activated only after light exposure and subsequent heating, allowing for repair and heat-processing of the thermoset films.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Neurosciences
Xenia Kobeleva, Ane Lopez-Gonzalez, Morten L. Kringelbach, Gustavo Deco
Summary: The brain rapidly processes and adapts to new information by transitioning between whole-brain functional networks at optimal spatial and temporal scales of around 300 regions and 150 ms, providing evidence for relevant spatiotemporal scales and recommendations for brain dynamics analyses.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Physics, Fluids & Plasmas
Hana Mir, James Stidham, Michel Pleimling
Summary: This study analyzes a structured heterogeneous system with a species having an advantage to escape predation in a habitat. Contrary to expectations, the predator of the advantaged species becomes the dominant species in the habitat. The species with the advantage initially has lower density until a threshold for the escape rate is exceeded, after which it overtakes its prey. The analysis is extended to a six-species system with spontaneous spiral waves.
Article
Mechanics
Sudeepta Mondal, Soumalya Sarkar
Summary: Data-driven prediction of spatiotemporal fields in fluid flow problems has become increasingly important. However, the accuracy of prevalent approaches is often affected by the scarcity of data, especially when generating high-fidelity data is expensive. This article proposes a novel multi-fidelity spatiotemporal modeling approach to reduce the overhead of high-fidelity simulations and improve the accuracy of predictions.
Article
Chemistry, Multidisciplinary
Tingting Chen, Yan Li, Xiongfei Jiang, Lingjie Shao
Summary: The study reveals that the dynamics of complex networks significantly affect the propagation of risk, which has been largely overlooked in previous research. By combining a dynamic model with empirical networks, it is found that hub nodes play a dominant role and exhibit a degree-driven effect in risk propagation. The impact of key dynamic parameters and the characteristics of complex financial systems on spatiotemporal patterns of risk propagation are also explored.
APPLIED SCIENCES-BASEL
(2023)
Article
Physics, Fluids & Plasmas
Zhiqiang Shen, Jihong Ma, Jan-Michael Y. Carrillo, Wei-Ren Chen, Bobby G. Sumpter, Yangyang Wang
Summary: The study of liquid dynamics at mesoscopic scales is challenging, but modern computational techniques and novel experimental methods have enabled a better understanding of the complexity and mechanisms involved. Through the spatiotemporal mapping method, one can comprehensively analyze the characteristics of mesoscopic dynamics in liquids, revealing the roles of various mechanisms such as molecular relaxation, hydrodynamic modes, and nonhydrodynamic excitations.
Article
Neurosciences
Xiaodi Zhang, Eric A. Maltbie, Shella D. Keilholz
Summary: Recent resting-state fMRI studies have shown that brain activity exhibits temporal variations in functional connectivity using various methods. However, the results from these methods are just a simplification of the continuous process of brain activity.
Article
Biochemistry & Molecular Biology
Georg Northoff, Jonas Daub, Dusan Hirjak
Summary: Despite progress in neurobiological/neurocomputational research in psychiatry, there is still a crisis of mechanism and subjectivity. Combining phenomenological psychopathology with spatiotemporal psychopathology can address these crises and provide new candidate biomarkers for diagnosis and treatment.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Ivar Noordstra, Richard G. Morris, Alpha S. Yap
Summary: Cell adhesion systems interact closely with the cytoskeleton. Adhesion receptors regulate the dynamics of the cortex, while the cytoskeleton influences adhesion strength and stability. Recent advances have focused on the interaction between classical cadherins and actomyosin, revealing a paradox in which adhesion strengthens under tension but can lead to intercalation in confluent tissues. Understanding timescales may be key in resolving this issue, requiring further research on adhesive strengthening at different scales.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Takahiro Shimojima, Asuka Nakamura, Xiuzhen Yu, Kosuke Karube, Yasujiro Taguchi, Yoshinori Tokura, Kyoko Ishizaka
Summary: The study successfully tracked the dynamics of skyrmions and revealed their evolution at different time scales. The repeatable motion of magnetic skyrmions around defects demonstrates the arrangement and relaxation of skyrmion clusters.
Article
Engineering, Multidisciplinary
Ziming Wen, Yu Li, Hu Wang, Yong Peng
Summary: This paper proposes a method called Stochastic Dependency Neural Estimator (SDNE), which constructs a mapping from the input parameter domain to the high-dimensional spatiotemporal response domain. It combines Graph Neural Networks (GNN) and Temporal Convolutional Neural Networks (TCN) to capture nonlinear features from irregular geometries and time series. The method is validated in high-speed impact cases and multi-objective crashworthiness optimizations, showing accurate predictions and practical application.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Biochemical Research Methods
Maheen Rana, Raheel Ahmad, Annette F. Taylor
Summary: Temporal control of pH in microreactors is crucial for applications such as biomineralization and microparticle synthesis. Researchers have successfully controlled the pH-time profile in emulsion droplets by combining an enzyme reaction with the properties of a water-oil-water double emulsion, allowing for the formation of pH sensitive materials and selective synthesis.
Article
Dentistry, Oral Surgery & Medicine
F. Yan, L. M. Simon, A. Suzuki, C. Iwaya, P. Jia, J. Iwata, Z. Zhao
Summary: By studying the expression patterns and regulatory networks of genes and miRNAs, we found complex spatiotemporal regulatory mechanisms in craniofacial development. We identified genes and miRNAs related to orofacial clefts and validated their roles in cleft palate.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Algirdas Toleikis, Martin R. Webb, Justin E. Molloy
SCIENTIFIC REPORTS
(2018)
Article
Biology
Saman Hussain, Carl N. Wivagg, Piotr Szwedziak, Felix Wong, Kaitlin Schaefer, Thierry Izore, Lars D. Renner, Matthew J. Holmes, Yingjie Sun, Alexandre W. Bisson-Filho, Suzanne Walker, Ariel Amir, Jan Lowe, Ethan C. Garner
Article
Biophysics
Shahid Khan, Kenneth H. Downing, Justin E. Molloy
BIOPHYSICAL JOURNAL
(2019)
Article
Biology
Karen Baker, Irene A. Gyamfi, Gregory I. Mashanov, Justin E. Molloy, Michael A. Geeves, Daniel P. Mulvihill
Article
Physiology
Gregory I. Mashanov, Tatiana A. Nenasheva, Tatiana Mashanova, Catherine Maclachlan, Nigel J. M. Birdsall, Justin E. Molloy
Summary: Recent advances in light microscopy have enabled the visualization of individual biological macromolecules in live cells with nanometer precision and high time resolution. This allows for direct observation of molecular interactions without bulk averaging, leading to new discoveries. While most single-molecule imaging studies have been done in unicellular organisms or cultured mammalian cell lines, there is potential to apply this approach to studying dynamics in different tissue samples.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas A. W. Bell, Justin E. Molloy
Article
Multidisciplinary Sciences
Nicholas A. W. Bell, Philip J. Haynes, Katharina Brunner, Taiana Maia de Oliveira, Maria M. Flocco, Bart W. Hoogenboom, Justin E. Molloy
Summary: PARP1 binds and condenses undamaged DNA by stabilizing DNA loops, and blocks condensation reversal for damaged DNA in the presence of NAD(+), suggesting a mechanism for PARP1 in the organization of chromatin structure.
Article
Biochemistry & Molecular Biology
Nicholas A. W. Bell, Justin E. Molloy
Summary: The paper introduces a simple and fast technique for creating diverse DNA constructs by combining PCR amplicons and synthetic oligonucleotides using golden gate assembly rules. The method allows for high-yield fabrication of torsionally-constrained DNA and various DNA hairpin structures, as well as improving measurement lifetime.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Torok, Matthew J. Hannah, Justin E. Molloy, Tom Carter
Summary: This study investigates the response of P-selectin to vascular damage. By tracking individual P-selectin molecules, it is found that they initially show fast diffusion but later become increasingly restricted in movement, with around 50% of the molecules becoming completely immobile. Manipulation of the molecule's structure or disruption of the adapter complex can alter its mobility. P-selectin spreads rapidly from sites of exocytosis and then becomes less mobile, which is better suited for its anchoring function.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Juha Vahokoski, Lesley J. Calder, Andrea J. Lopez, Justin E. Molloy, Inari Kursula, Peter B. Rosenthal
Summary: In this study, the structure of the malaria parasite motor complex was presented, including the actin 1 and myosin A with its associated light chains. Malaria is a deadly disease that causes significant mortality and economic burden globally, and the parasite responsible for the disease relies on the actomyosin motor complex for its motility and invasion. Understanding the structure of this complex provides insights for drug development targeting this complex.
Article
Biochemistry & Molecular Biology
Isa Pires, Yu-Fu Hung, Ulrich Bergmann, Justin E. Molloy, Inari Kursula
Summary: MyoB, a myosin expressed in the invasive stages of Plasmodium falciparum, contributes to red blood cell invasion. It binds to actin and multiple regulatory light chains, exhibits ATPase activity, and moves actin filaments. Its specific localization, high affinity to actin, and ability to sense and apply force may be important for early stages of invasion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Athinoula Meli, Ann McCormack, Ianina Conte, Qu Chen, James Streetley, Marlene L. Rose, Ruben Bierings, Matthew J. Hannah, Justin E. Molloy, Peter B. Rosenthal, Tom Carter
Summary: Cellular and environmental stresses associated with heart disease and heart failure can alter the storage and secretion of VWF, leading to changes in the morphology and function of Weibel-Palade bodies (WPBs) in cardiac microvascular endothelial cells. In patients with dilated cardiomyopathy, WPBs exhibit rounded shape with disordered arrangement of VWF tubules, resulting in impaired VWF deployment during secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nicholas A. W. Bell, Justin E. Molloy
Summary: In this study, a new experimental method was developed to measure the mechanical stability and interaction kinetics of proteins across the two ends of a DNA double-strand break. It was found that PARP2 forms a stable mechanical link across blunt-end 5;- phosphorylated DSBs and restores torsional continuity. In contrast, PARP1 was not observed to form a bridging interaction across blunt or short overhang DSBs and competed away PARP2 bridge formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
Gregory Mashanov, Tatiana A. Nenasheva, Alla Mashanova, Remigijus Lape, Nigel J. M. Birdsall, Lucia Sivilotti, Justin E. Molloy
Summary: The study utilized high-resolution techniques to investigate differences in membrane viscosity, revealing significant variations in membrane mobility across different cell types, with some regions of the membrane showing significantly higher viscosity than others.
FARADAY DISCUSSIONS
(2021)
Article
Chemistry, Multidisciplinary
Bernice Akpinar, Philip J. Haynes, Nicholas A. W. Bell, Katharina Brunner, Alice L. B. Pyne, Bart W. Hoogenboom