Article
Plant Sciences
Bodan Su, Anqi Wang, Xiaoyi Shan
Summary: This study reveals the crucial role of N-myristoylation in the proper plasma membrane targeting and protein stability of BSK1. The N-myristoylation-deficient mutant BSK1(G2A) is mainly distributed in the cytoplasm and degraded through ATG8e-labeled autophagic pathway.
Article
Microbiology
Adam Istvan Hegyi, Margot Otto, Jozsef Geml, Julia Hegyi-Kalo, Jozsef Kun, Attila Gyenesei, Rian Pierneef, Kalman Zoltan Vaczy
Summary: This study analyzed the gene expression data during the noble rot process in grapes, revealing the important genes for grape berry structural integrity and the dominant role of Botrytis cinerea in this process.
Article
Multidisciplinary Sciences
Biswa R. Acharya, Devinder Sandhu, Christian Duenas, Marco Duenas, Manju Pudussery, Amita Kaundal, Jorge F. S. Ferreira, Donald L. Suarez, Todd H. Skaggs
Summary: The sensitivity of almond crop to salinity stress can lead to significant yield losses, making it important to develop salt-tolerant rootstocks. A study comparing two commercial rootstocks found that 'Rootpac 40' had higher survival rates and lower Na and Cl accumulation compared to 'Nemaguard' under salinity conditions. Analysis of differentially expressed genes revealed insights into the regulation of salinity tolerance in Prunus.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Akanksha Gandhi, Rupesh Kariyat, Amaravadhi Harikishore, Marzieh Ayati, Anirban Bhunia, Nirakar Sahoo
Summary: Plants and insect herbivores engage in a relentless battle, with plants evolving strategies to detect and defend against herbivores through physical, structural, and chemical barriers. Plants perceive herbivory through mechanical and chemical means, with ion channels acting as first responders in defense signaling pathways. Recent studies have focused on early plant defense signaling in response to herbivory, highlighting the crucial role of ion channels.
Article
Multidisciplinary Sciences
Ying Tang, Adewunmi Adelaja, Felix X-F Ye, Eric Deeds, Roy Wollman, Alexander Hoffmann
Summary: The authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli in NF kappa B, MAPK and p53 signaling pathways.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Jian Lu, Yingying Qin, Chunxiang Li, Yilin Wu, Minjia Meng, Zeqing Dong, Chang Sun, Muning Chen, Yongsheng Yan
Summary: This work presents the development of irregular dot array nanocomposite bisphenol A (BPA)-molecularly imprinted membranes (BPA-MIMs) through a modification-by-imprinting strategy, with superior selectivity, rebinding capacity, and flux. The membranes show impressive permselectivity coefficients and stability, along with concentration-dependent and time-dependent cumulative selectivity, demonstrating the potential for membrane-based water treatment and specific separation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Hiroyuki Tokiwa, Kazutaka Ueda, Eiki Takimoto
Summary: Sexual dimorphism exists in cardiovascular disease, indicating the involvement of sexual hormones. Estrogen has a protective effect on the cardiovascular system. Non-nuclear signaling of estrogen has been poorly understood, but recent research has shed new light on this pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cell Biology
Miao Li, Yan Yu
Summary: The discovery of receptor clustering on the surfaces of innate immune cells has shed light on the key role these clusters play in pathogen detection and immune response regulation. Despite being a relatively under-explored research topic, pioneering studies have highlighted the importance of understanding the functional role of receptor clustering in innate immune regulation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Der-Yen Lee, Yu-Chin Lin, Geen-Dong Chang
Summary: MG is a reactive glycation metabolite that can induce dicarbonyl stress, and its production in cells is influenced by carbohydrate metabolism. The glyoxalase system consisting of GlxI and GlxII is crucial for converting MG into nontoxic metabolites. Insulin stimulation leads to the accumulation of MG and S-d-lactoylglutathione in cells, which can be efficiently removed by metformin. Metformin affects the glyoxalase system by controlling the redox state and may help maintain cellular MG homeostasis.
Review
Endocrinology & Metabolism
Shuhui Zheng, Lin Wu, Chao Fan, Jingxia Lin, Yaxing Zhang, Tommaso Simoncini, Xiaodong Fu
Summary: G alpha plays a crucial role in mER-mediated signaling, involving processes such as vascular EC migration, endothelial H2S release, breast cancer cell invasion, neural regulation of energy balance, and osteogenesis.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Immunology
Ward Vleeshouwers, Koen van den Dries, Sandra de Keijzer, Ben Joosten, Diane S. Lidke, Alessandra Cambi
Summary: This study highlights the modulation of myeloid immune cell function by Prostaglandin E2 (PGE2) through the activation of EP2 and EP4 receptors. EP4 plays a key role in podosome loss in DCs, while both EP2 and EP4 signaling lead to different cAMP production profiles and reciprocal control of signaling pathways. Efficient signaling of both EP2 and EP4 relies on an intact microtubule network, enhancing our understanding of early signaling events in myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Li-Bo Yuan, Tao Jin, Ling Yao, De-Hong Yin, Yong-Qing Xu
Summary: This study explored the mechanism of the p38MAPK signaling pathway in repairing articular cartilage defects with biological collagen membranes. The results showed that the biological collagen membrane could regulate the expression of MMP1 and MMP13, repair the activity of chondrocytes, and improve the repair effect of articular cartilage defects by reducing the phosphorylation level of p38MAPK and inhibiting the activation of the p38MAPK signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Alexander J. Gates, Rion Brattig Correia, Xuan Wang, Luis M. Rocha
Summary: The ability to map causal interactions underlying genetic control and cellular signaling has led to increasingly accurate models of complex biochemical networks. The introduction of the effective graph has improved the understanding of redundancy and effectiveness in pathways, providing a more enriched description of network dynamics and enhancing explainability, prediction, and control of complex dynamical systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Danai Maria Kotzampasi, Kyriaki Premeti, Alexandra Papafotika, Vasiliki Syropoulou, Savvas Christoforidis, Zoe Cournia, George Leondaritis
Summary: This article investigates the interplay between PI3Ka and PTEN in cellular signaling and membrane trafficking, discusses the impact of their structure and catalytic activity on signaling, and explores the potential for pharmacological targeting of these proteins.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Engineering, Environmental
Jing Yan, Yingrui Sui, Ming Yan, Yilin Wu
Summary: In this study, Ag & TiO2-based propranolol-imprinted layers were prepared on a basswood membrane surface using a polydopamine-induced self-polymerization/composite strategy. The resulting nanocomposite membranes exhibited excellent specific recognition capability and permselectivity towards propranolol. The natural curved channel of basswood promoted the diffusion process and improved contact efficiency. This study successfully prepared a material with high-intensity recognizability and permeability towards propranolol.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Jenny M. Poulton, Pieter Rein ten Wolde, Thomas E. Ouldridge
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Chemistry, Physical
Thomas R. Sokolowski, Joris Paijmans, Laurens Bossen, Thomas Miedema, Martijn Wehrens, Nils B. Becker, Kazunari Kaizu, Koichi Takahashi, Marileen Dogterom, Pieter Rein ten Wolde
JOURNAL OF CHEMICAL PHYSICS
(2019)
Article
Physics, Multidisciplinary
Yao Li, Pieter Rein ten Wolde
PHYSICAL REVIEW LETTERS
(2019)
Article
Physics, Multidisciplinary
Harmen Wierenga, Pieter Rein ten Wolde
PHYSICAL REVIEW LETTERS
(2020)
Article
Biology
Giulia Malaguti, Pieter Rein ten Wolde
Summary: By studying how living cells measure chemical concentrations, it was found that there are two basic design principles for optimal sensing systems, and these principles were applied to analyze the Escherichia coli chemotaxis system.
Article
Multidisciplinary Sciences
Lorenzo Olivi, Mareike Berger, Ramon N. P. Creyghton, Nicola De Franceschi, Cees Dekker, Bela M. Mulder, Nico J. Claassens, Pieter Rein ten Wolde, John van der Oost
Summary: Recent developments in synthetic biology may bring the generation of a synthetic cell within reach, with a key feature being a functional cell cycle. While progress has been made in establishing individual machineries, integrating and controlling them in a synthetic cell cycle is still a challenge to be addressed. This Perspective discusses potential paths towards achieving an integrated synthetic cell cycle.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Celine Alkemade, Harmen Wierenga, Vladimir A. Volkov, Magdalena Preciado Lopez, Anna Akhmanova, Pieter Rein ten Wolde, Marileen Dogterom, Gijsje H. Koenderink
Summary: This study reveals the mechanism of passive cross-linkers generating forces in the interaction between actin and microtubules, and experimentally verifies this process. The results demonstrate that passive cross-linkers can facilitate the transportation of actin filaments on microtubules, which is significant for cellular remodeling processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Mareike Berger, Pieter Rein ten Wolde
Summary: The study investigates the replication initiation cycles of Escherichia coli at different growth rates and reveals that both the titration mechanism and the activation switch play crucial roles in driving stable replication cycles.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Fluids & Plasmas
Harmen Wierenga, Pieter Rein ten Wolde
Summary: Cell polarization, which plays a crucial role in various cellular processes, requires the breaking of detailed balance and can be achieved through two mechanisms: active transport and nonequilibrium binding. Moreover, a chemical modification cycle is found to be more efficient than transport-based processes in creating a polarized distribution of membrane-bound proteins.
Article
Physics, Fluids & Plasmas
G. Malaguti, P. R. ten Wolde
Summary: Living cells can measure chemical concentrations accurately, and reducing sensing error by increasing receptor time integration is a widely used mechanism. However, how to optimally implement this mechanism given cellular resource constraints remains unknown.
Article
Physics, Fluids & Plasmas
Matthijs Meijers, Sosuke Ito, Pieter Rein ten Wolde
Summary: Recent experiments suggest that biological systems self-organize near their critical point, with information transmission efficiency depending on the dynamics of the input signal, its correlation time, and the distance to the critical point. Instantaneous mutual information varies nonmonotonically with temperature, but increases monotonically with input signal correlation time. There exists an optimal temperature and optimal input correlation time that maximize information transmission rate, due to the trade-off between message frequency, response speed, and reliability.
Article
Chemistry, Physical
Krzysztof Bielec, Krzysztof Sozanski, Marco Seynen, Zofia Dziekan, Pieter Rein ten Wolde, Robert Holyst
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Chemistry, Physical
Yuval Mulla, Harmen Wierenga, Celine Alkemade, Pieter Rein ten Wolde, Gijsje H. Koenderink
Article
Physics, Fluids & Plasmas
Harmen Wierenga, Pieter Rein ten Wolde, Nils B. Becker
Article
Physics, Fluids & Plasmas
Michele Monti, David K. Lubensky, Pieter Rein ten Wolde