Article
Chemistry, Physical
Yufeng Jiao, Cunjun Ruan, Kanglong Chen, Yubo Wu, Wenlong He
Summary: A special data processing method is proposed in this study to analyze the characteristics of a polar mixed liquid using terahertz frequency domain reflection spectroscopy. By utilizing Hilbert transform, stationary wavelet transform, and time domain zero setting method, the reflection coefficient can be obtained by the self-reference calibration method. The study lays a solid foundation for future research on the microscopic mechanism of intermolecular interaction using terahertz frequency domain reflection spectroscopy.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Engineering, Chemical
Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie MacLean, Marian Bentley, Andrew P. E. York, Michele Marigo, Karen Huang, J. Axel Zeitler
Summary: This study investigated the liquid transport kinetics of solid catalysts using Terahertz pulsed imaging (TPI) coupled with a flow cell, revealing the impact of porosity and wettability on liquid transport rates. The results demonstrate the potential of TPI for studying and optimizing the design and performance of such materials.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Article
Multidisciplinary Sciences
Ruwan Senaratne, Danyel Cavazos-Cavazos, Sheng Wang, Feng He, Ya-Ting Chang, Aashish Kafle, Han Pu, Xi-Wen Guan, Randall G. Hulet
Summary: Confining ultracold atoms to periodic potentials is a powerful method for simulating complex many-body systems. In this study, we confined fermions to one dimension to realize the Tomonaga-Luttinger liquid model and observed a velocity shift of spin and charge excitations in opposite directions, indicating the existence of spin-charge separation.
Article
Chemistry, Physical
Poonam Singh, Jia Zhang, Dieter Engel, Benjamin P. P. Fingerhut, Thomas Elsaesser
Summary: We introduce the transient THz Stark effect to modify the electronic absorption spectra of dye molecules and determine molecular interactions and dynamics. The non-equilibrium response of Betaine-30 in a polar solution is probed via transient absorption changes induced by picosecond electric fields. The response is governed by the dipole energies in the THz field, allowing for quantification of electric forces in a structurally frozen molecular environment.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Spectroscopy
Zhenqi Zhu, Yujing Bian, Xun Zhang, Ruonan Zeng, Bin Yang
Summary: The research found that hydroxyproline (HYP) and pyroglutamic acid (PGA) have stronger absorption of terahertz waves due to the presence of polar substituents. Additionally, the absorption peaks of HYP and PGA show significant red and blue shifts respectively, which is believed to be caused by changes in the strength of intermolecular hydrogen bonds.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Nanoscience & Nanotechnology
Rayko Ivanov Stantchev, Kaidi Li, Emma Pickwell-MacPherson
Summary: The research reports the first use of a convolutional neural network in terahertz (THz) imaging with a single-pixel camera, achieving high-quality hyperspectral THz imaging 10 times faster than current commercial systems, limited only by noise. The key breakthrough of synchronizing the equipment eliminates the need for additional time to instruct the ODU to move while projecting patterns.
Article
Ecology
Gioele Passoni, Tim Coulson, Francesca Cagnacci, Peter Hudson, Daniel R. Stahler, Douglas W. Smith, Shelly Lachish
Summary: A central debate in ecology has been the long-running discussion on the role of apex predators in affecting the abundance and dynamics of their prey. This study presents a bioenergetic mechanistic model of a tritrophic system and investigates the impact of wolf reintroduction on the system. The model reveals the important role of wolves in shifting the elk population from being food-limited to being predator-limited and stabilizing elk numbers.
Article
Multidisciplinary Sciences
Elmar Slikboer, James Walsh
Summary: The study found that the interaction between an argon plasma jet and a liquid target is highly influenced by the electrical characteristics of the target, resulting in typical dielectric barrier discharge behavior with high resistance grounding and DC-like discharge with low resistance grounding.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Runqiao Dong, J. Axel Zeitler
Summary: The dissolution of coated pharmaceutical tablets is a complex process that depends on the structure of the coating and its interaction with the tablet core. This study used terahertz pulsed imaging to investigate the penetration of the dissolution medium into coated tablets. The analysis revealed a discontinuity in density at the interface between the coating and core, which affected the liquid transport and dissolution performance. The study provides insights into the role of coating in tablet dissolution.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Wei-Fan Chiang, Yu-Yun Lu, Yin-Pei Chen, Xin-Yu Lin, Tsong-Shin Lim, Jih-Hsin Liu, Chia-Rong Lee, Chia-Yi Huang
Summary: Liquid crystal cells coated with metamaterials were fabricated, with experimental results showing an increase in resonance frequencies with a specific angle, demonstrating potential as passively tunable terahertz filters.
Article
Chemistry, Analytical
Zhengmin Tang, Jianbo Miao, Quancheng Liu, Weiwei Qu, Lichuan Luo, Liping Shang, Hu Deng
Summary: This study utilizes terahertz time domain spectroscopy to measure the optical parameters of aqueous AP samples and constructs five quantitative prediction models. The optimized extreme learning machine model based on the absorption coefficient with the help of chemometrics shows the best prediction results for moisture content. The research provides a reliable basis for accurate prediction of the moisture content of AP and similar substances, paving the way for rapid and non-destructive detection methods.
MICROCHEMICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Runqiao Dong, Marwa Nassar, Barry Friend, Jason Teckoe, J. Axel Zeitler
Summary: Coated tablets introduce complexity to the dissolution process, even with readily soluble immediate release coating layers. The current study uses terahertz pulsed imaging to visualise the hydration process of microcrystalline cellulose (MCC) tablet cores that were film coated with an immediate release coating formulation upon exposure to the dissolution medium. The penetration rate through the coating layer and the tablet core both strongly depended on coating thickness and core porosity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Crystallography
Yi-Hong Shih, Xin-Yu Lin, Harry Miyosi Silalahi, Chia-Rong Lee, Chia-Yi Huang
Summary: The study demonstrated the fabrication of an optically tunable terahertz filter using a metasurface-imbedded liquid crystal cell with photoalignment layers. Experimental results showed an increase in resonance frequency of the metasurface in the cell with the LC director angles, and a frequency tuning region of 15 GHz was achieved. Simulated results indicated the resonance frequency shift was due to the birefringence of the LC, with a value of 0.13 in the terahertz region. This optically tunable terahertz filter has potential applications in terahertz telecommunication, biosensing, and terahertz imaging.
Article
Spectroscopy
Yin Shen, Bin Li, Guanglin Li, Chongchong Lang, Haifeng Wang, Jun Zhu, Nan Jia, Lirong Liu
Summary: This research aims to develop a new method for determining the producing areas of wheat by using terahertz time domain spectroscopy combined with chemometrics. Through the comparison of different preprocessing methods and models, it is concluded that terahertz time domain spectroscopy combined with chemometrics can provide a fast and accurate solution for analyzing the producing areas of wheat.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Bin Li, Junpeng Bai, Shujuan Zhang
Summary: A new metamaterial method based on terahertz spectroscopy was developed in this study to detect low concentrations of the quinolone antibacterial drug noroxin, providing a theoretical and experimental basis for the rapid detection of antibiotic residues in food matrices. The method presented a noroxin detection limit of 0.01 µg/mL, demonstrating its effectiveness in detecting low concentrations of the antibiotic.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Materials Science, Multidisciplinary
Suling Shen, Xudong Liu, Yaochun Shen, Junle Qu, Emma Pickwell-MacPherson, Xunbin Wei, Yiwen Sun
Summary: Terahertz metamaterial sensing (TMS) technology is an interdisciplinary technology with large penetration depth and high sensitivity, widely used in various fields such as biomedicine, food safety, environmental monitoring, industry, and agriculture. The performance of TMS is not only determined by the structural topology of metamaterials, but also by their compositions and substrates.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Optics
Xuefei Ding, A. Hernandez-Serrano, Hannah Lindley-Hatcher, Rayko Stantchev, Jun Zhou, Emma Pickwell-MacPherson
Summary: This paper proposes an optimized multilayer structure for sensitive characterization of thin-film aqueous solutions. The best structure is found through theoretical simulations, and high sensitivity is achieved in glucose solution measurements. This work provides a new approach for THz thin-film characterization.
Article
Chemistry, Analytical
Xavier E. Ramirez Barker, Rayko I. Stanchev, Arturo I. Hernandez Serrano, Emma Pickwell-MacPherson
Summary: This study presents a finite rate of innovation method applied specifically to terahertz signals, achieving low sampling rates and faster data acquisition.
Article
Optics
X. Chen, E. Pickwell-MacPherson
Summary: Traditional terahertz spectroscopy methods have limitations in certain cases, while terahertz ellipsometry, as a self-reference characterization technique with wide adaptability, can be applied to almost all sample types.
Article
Multidisciplinary Sciences
Sae June Park, Robyn Tucker, Emma Pickwell-MacPherson, John E. Cunningham
Summary: Finite element method simulations are used to investigate the response of terahertz split-ring resonators integrated with on-chip terahertz waveguides to cancerous tissues. The transmission spectra of the integrated system are obtained for different tissue states, and it is found that resonant frequency shift can be used to distinguish cancerous and healthy tissues. The electric field distribution and magnitude near the resonators are investigated for different gap widths, and simulated imaging shows the potential application of the technique in distinguishing tumor margins.
ADVANCED THEORY AND SIMULATIONS
(2022)
Article
Chemistry, Multidisciplinary
Peilin Fang, Xianglin Ji, Xi Zhao, Richard Yan-Do, Youyang Wan, Ying Wang, Yuanting Zhang, Peng Shi
Summary: A self-healing bioelectronic patch (iMethy) combining transdermal fluid extraction with field effect transistor-based biosensing is developed for dynamic monitoring of methylated ctDNAs as a prognostic approach for cancer risk management. The patch can detect ctDNAs as low as 10(-16) m and perform phenotypic analysis of tumor growth in rodent animals. This proof-of-concept study demonstrates the potential of the iMethy platform for real-time in vivo analysis of disease-indicative biomarkers, offering a painless and self-administrable procedure for dynamic transdermal surveillance of methylated ctDNAs in cancer risk management.
ADVANCED MATERIALS
(2023)
Article
Computer Science, Information Systems
Chuanhao Zhang, Emil Jovanov, Hongen Liao, Yuan-Ting Zhang, Benny Lo, Yuan Zhang, Cuntai Guan
Summary: With the development of modern cameras, physiological signals can now be obtained from portable devices like smartphones. In this paper, a framework called cocktail causal container is proposed to fuse multiple physiological representations and reconstruct the correlation between frequency and temporal information for blood pressure and blood glucose classification. The framework utilizes a token feature fusion block and a causal net to extract discriminative features and disentangle latent factors. A pair-wise temporal frequency map is also developed for extracting PPG information. Extensive comparisons using clinical data and PPG-BP benchmark show promising results with low error rate and high precision.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Computer Science, Information Systems
Fang Ye, Sumit Majumder, Wei Jiang, Xiaohe Li, Narayanaswamy Balakrishnan, Yuanting Zhang, M. Jamal Deen
Summary: Deadly infectious diseases have occurred throughout human history, and despite advanced healthcare systems, COVID-19 has caused over six million deaths worldwide as of July 27, 2022. Contact tracing is a tool used to monitor and control disease spread, but manual contact tracing is challenging and time-consuming. Many digital contact tracing applications have been developed globally, and this study reviews the current technologies, proposes an integrated system for contact tracing using COVID-19 as a case study, and introduces four main modules to evaluate users' risk and provide notifications. The system also integrates web-based information and screening tools to increase its adoption rate.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Biology
Lei Liu, Yuan-Ting Zhang, Wenyan Wang, Yifan Chen, Xiaorong Ding
Summary: Using wearable sensing and machine learning techniques, this study examines the feasibility of causal inference for cuffless blood pressure estimation. It first identifies wearable features causally related to blood pressure changes by detecting causal graphs of interested variables. Then, a time-lagged link is employed to integrate the mechanism of causal inference into the blood pressure estimation model. The proposed method outperforms traditional models without consideration of causality, achieving estimation errors of 5.10 mmHg and 2.85 mmHg for SBP and DBP, respectively. This work sheds light on the mechanism, method, and application of cuffless blood pressure measurement.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Computer Science, Information Systems
Shirong Qiu, Yuan-Ting Zhang, Sze-Kei Lau, Ni Zhao
Summary: A pattern-fusion method is proposed to improve the accuracy of cuffless blood pressure measurement by incorporating cardiovascular coupling effects in the vascular model through three calculation modules.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Review
Health Care Sciences & Services
Lei Zhao, Cunman Liang, Yan Huang, Guodong Zhou, Yiqun Xiao, Nan Ji, Yuan-Ting Zhang, Ni Zhao
Summary: Cardiovascular diseases (CVDs) are one of the major causes of death worldwide, and monitoring blood pressure (BP) is vital for their early diagnosis and management. This review focuses on wearable and cuffless BP monitoring technologies, including flexible sensor designs and BP extraction algorithms. The sensors are classified into electrical, optical, and mechanical types, and the review briefly discusses the choices, fabrication methods, and performances of each type. The review also introduces contemporary algorithmic methods for beat-to-beat BP measurements and continuous BP waveform extraction, comparing their features and performances.
NPJ DIGITAL MEDICINE
(2023)
Article
Computer Science, Information Systems
Zeng-Ding Liu, Ye Li, Yuan-Ting Zhang, Jia Zeng, Zu-Xian Chen, Zhi-Wei Cui, Ji-Kui Liu, Fen Miao
Summary: This study evaluated the performance of cuffless blood pressure measurement techniques in a large and diverse cohort. The findings suggest that smartwatches are effective for measuring blood pressure for most participants, but the accuracy decreases in heterogeneous populations including older and hypertensive participants.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Proceedings Paper
Computer Science, Information Systems
Lei Lu, Tingting Zhu, Yuan-Ting Zhang, David A. Clifton
Summary: This paper proposes a model based on matrix completion for estimating incomplete spectrum of HRV data. Experimental and comparative studies show that the model performs efficiently and accurately in spectrum estimation.
2022 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) JOINTLY ORGANISED WITH THE IEEE-EMBS INTERNATIONAL CONFERENCE ON WEARABLE AND IMPLANTABLE BODY SENSOR NETWORKS (BSN'22)
(2022)
Article
Chemistry, Multidisciplinary
Chunki Yiu, Yiming Liu, Chao Zhang, Jingkun Zhou, Huiling Jia, Tsz H. Wong, Xingcan Huang, Jian Li, Kuanming Yao, Ming K. Yau, Ling Zhao, Hu Li, Binbin Zhang, Wooyoung Park, Yuanting Zhang, Zuankai Wang, Xinge Yu
Summary: Researchers have developed a soft, stretchable, three-lead ECG device that enables continuous monitoring and wireless transmission of ECG signals, which could aid in early diagnosis of cardiovascular diseases. The device utilizes an organohydrogel patch with strong adhesive ability and high conductivity for high-quality ECG signal collection. It also incorporates machine learning algorithms and a graphical user interface for real-time ECG monitoring and diagnosis of cardiac abnormalities.
Article
Endocrinology & Metabolism
Xu Jing, Jieyu Wu, Caijuan Dong, Juan Gao, Takahiro Seki, Changil Kim, Egon Urgard, Kayoko Hosaka, Yunlong Yang, Siwen Long, Ping Huang, Junnian Zheng, Laszlo Szekely, Yuanting Zhang, Wei Tao, Jonathan Coquet, Minghua Ge, Yuguo Chen, Mikael Adner, Yihai Cao
Summary: COVID-19 infection enhances adipose browning and non-shivering thermogenesis, leading to adipose atrophy and weight loss. Inhibition of vascular endothelial growth factor (VEGF) signaling may represent an effective approach for preventing and treating COVID-19-associated weight loss.
