期刊
BIOPHYSICAL JOURNAL
卷 101, 期 11, 页码 L57-L59出版社
CELL PRESS
DOI: 10.1016/j.bpj.2011.10.028
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类别
资金
- National Institutes of Health [AI14584, P01 AI072677, AI29575, AI44129, CA108835]
- Natural Sciences and Engineering Research Council (Canada)
- Canadian Institutes of Health Research
Changes in the clustering of surface receptors modulate cell responses to ligands. Hence, global measures of receptor clustering can be useful for characterizing cell states. Using T cell receptor for antigen as an example, we show that k-space image correlation spectroscopy of quantum dots blinking detects T cell receptor clusters on a scale of tens of nano-meters and reports changes in clustering after T cell activation. Our results offer a general approach to the global analysis of lateral organization and receptor clustering in single cells, and can thus be applied when the cell type of interest is rare.
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