Article
Gastroenterology & Hepatology
Jiajun Fu, Fengjiao Hu, Tengfei Ma, Wen-Jie Zhao, Han Tian, Yan Zhang, Manli Hu, Junjie Zhou, Yanfang Zhang, Chongshu Jian, Yan-Xiao Ji, Xiao-Jing Zhang, Jingwei Jiang, Zhi-Gang She, Xu Cheng, Peng Zhang, Lan Bai, Juan Yang, Hongliang Li
Summary: Although the prevalence of NAFLD has increased to 25% of the adult population worldwide, there are currently no approved pharmacological interventions due to uncertainty about the underlying molecular mechanisms. It has been found that mitochondrial dysfunction plays a crucial role in the development of NAFLD. The mitochondrial antiviral signaling protein (MAVS) has been identified as protective against diet-induced NAFLD, with its deficiency leading to extensive mitochondrial dysfunction. This suggests that targeting MAVS could be a potential avenue for treating NAFLD.
Article
Biochemistry & Molecular Biology
Alessandra Ferramosca, Stefano Lorenzetti, Mariangela Di Giacomo, Paola Lunetti, Francesco Murrieri, Loredana Capobianco, Vincenza Dolce, Lamberto Coppola, Vincenzo Zara
Summary: Plant bioactives, such as polyphenols, can have differential effects on sperm quality depending on their concentration, with some compounds improving mitochondrial function in asthenozoospermic samples. This study highlights the potential of natural antioxidants in nutraceutical supplementation for male infertility treatment.
Article
Biochemistry & Molecular Biology
Nicolas Tricaud, Benoit Gautier, Jade Berthelot, Sergio Gonzalez, Gerben Van Hameren
Summary: This study found that after nerve injury, there are changes in the pH, motility, and calcium content of Schwann cell mitochondria, leading to demyelination. Calcium release through VDAC channels plays a crucial role in this process. The altered kinetics of mitochondrial calcium release in diabetic mice suggest a potential mechanism for the development of peripheral neuropathy. Blocking VDAC could be a promising target for developing drugs to treat diabetic peripheral neuropathy.
Review
Biochemistry & Molecular Biology
Paulina Sander, Thomas Gudermann, Johann Schredelseker
Summary: Research on mitochondrial Ca2+ uptake mainly focuses on the function, regulation, and localization of the mitochondrial calcium uniporter complex (MCUC), while also investigating the role of the outer mitochondrial membrane channels in regulating this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Pierpaolo Risiglione, Federica Zinghirino, Maria Carmela Di Rosa, Andrea Magri, Angela Messina
Summary: The function of alpha-Synuclein, its interaction with VDAC, and its involvement in pathological processes are the main focus of current research on mitochondrial function modulation.
Article
Nutrition & Dietetics
Drajat Martianto, Atikah Bararah, Nuri Andarwulan, Dominika srednicka-Tober
Summary: This study investigated plant sterols intake and food sources in Bogor, Indonesia, revealing an average intake of 229.76 mg/day mainly from cereals, vegetables, and fruit products. A list of potential plant sterol-enriched food items was developed for future functional food development in Indonesia. Further research is needed to confirm the efficacy and safety of introducing such products into habitual diets.
Article
Biochemistry & Molecular Biology
Victor V. Lemeshko
Summary: Recently reported kinase-linked mild depolarization of mitochondria may be a crucial component of the mitochondrial anti-aging program. However, the current measurement methods for mitochondrial inner membrane potential ignore the possibility of outer membrane potential generation. The experimental data reported in this study may reflect changes in the positive outer membrane potential generated by VDAC-kinase complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Multidisciplinary Sciences
Chaiheon Lee, Jung Seung Nam, Chae Gyu Lee, Mingyu Park, Chang-Mo Yoo, Hyun-Woo Rhee, Jeong Kon Seo, Tae-Hyuk Kwon
Summary: Mitochondrial oxidation-induced cell death, an important physiological process activated by cancer therapeutics, is challenging to investigate. The authors report a multifunctional iridium(III) photosensitiser, Ir-OA, capable of inducing mitochondrial oxidative stress and monitoring the corresponding changes in mitochondrial properties.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Ashlesha Kadam, Pooja Jadiya, Dhanendra Tomar
Summary: Mitochondria play a critical role in energy metabolism and signal transduction, which is regulated by proteins, metabolites, and ion fluxes. Mitochondrial membranes have distinct permeabilities to ions and metabolites. Channels and transporters on the outer and inner mitochondrial membranes mediate metabolite and ion fluxes, and are regulated by post-translational modifications. The mitochondrial protein quality control system ensures efficient molecular flux and removal of mistargeted or defective proteins. Understanding mitochondrial channels and transporters is crucial for maintaining cellular homeostasis and preventing pathological conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Food Science & Technology
Elisa Turini, Miriana Sarsale, Davide Petri, Michele Totaro, Ersilia Lucenteforte, Lara Tavoschi, Angelo Baggiani
Summary: Plant sterols/phytosterols can be used as a natural therapy to reduce LDL cholesterol levels, especially for patients with LDL-c levels >= 140 mg/dL and when used in dosages > 2 g/day.
Article
Medicine, Research & Experimental
Kareem A. Heslop, Pieter Burger, Christiana Kappler, Ashish K. Solanki, Monika Gooz, Yuri K. Peterson, Catherine Mills, Thomas Benton, Stephen A. Duncan, Patrick M. Woster, Eduardo N. Maldonado
Summary: In this study, a novel small molecule targeting VDAC, SC18, was identified, which can induce mitochondrial dysfunction and inhibit cell proliferation in liver cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Penghao Ji, Shenyan Zhang, Peilei Liu, Xi Li, Weichao Bao, Xiangzhi Cui, Minfeng Huo, Jianlin Shi
Summary: Programmed cell death (PCD) plays a crucial role in combating tumors in the field of biomedicine. However, malignant tumor cells often develop resistance to commonly used anticancer drugs. A newly designed nanoassembly OA@IR820 targets mitochondria and releases ATP synthase inhibitor OA, leading to ATP synthesis inhibition and mitochondrial dysfunction, thereby promoting oxidative stress-mediated pyroptosis and offering a potential therapeutic strategy for malignant tumor treatment.
Article
Biochemistry & Molecular Biology
Weiyi Shen, Yixing Wang, Wentao Shao, Qihan Wang, Zhaoyan Jiang, Hai Hu
Summary: The study found that plant sterols can inhibit intestinal cholesterol absorption, thus preventing the formation of cholesterol gallstones.
Review
Nutrition & Dietetics
Anna-Lena Mueller, Aranka Brockmueller, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Tendinitis is a common tendon disease caused by mechanical overuse, injuries, drug abuse, and lifestyle factors. Nuclear factor kappa B is an important pro-inflammatory transcription factor that regulates genes involved in inflammation, degradation, and cell death. Plant-derived nutraceuticals can target multiple signaling pathways and suppress inflammation in tendinitis.
Article
Neurosciences
Xiaofan Ning, Xinyue Li, Kai Ma, Huan Pang, Tiantian Tian, Huifang Hao, Qiaohong Hou, Meng Li, Tianxiang Liu, Shanshan Hou, Haiying Du, Xiuling Song, Zhiwei Sun, Chao Zhao, Minghua Jin
Summary: Silica nanoparticles are widely used in industry, electronics, and pharmaceutical industries, as well as medicine, tumor treatment and diagnosis, and other biomedical and biotechnology fields. The increasing exposure to silica nanoparticles through iatrogenic, occupational, and environmental sources has raised concerns about their potential damage and effects on the nervous system.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carolina L. Goulart, Paulo M. Bisch, Wanda M. A. von Krueger, Fabrice Homble
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2015)
Review
Biochemistry & Molecular Biology
Fabrice Homble, Eva-Maria Krammer, Martine Prevost
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2012)
Article
Biochemistry & Molecular Biology
Eva-Maria Krammer, Fabrice Homble, Martine Prevost
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2013)
Article
Plant Sciences
Marie Baucher, Yves Oukouomi Lowe, Olivier M. Vandeputte, Johnny Mukoko Bopopi, Jihad Moussawi, Marjorie Vermeersch, Adeline Mol, Mondher El Jaziri, Fabrice Homble, David Perez-Morga
JOURNAL OF EXPERIMENTAL BOTANY
(2011)
Article
Chemistry, Physical
Yann Gambin, Myriam Reffay, Emma Sierecki, Fabrice Homble, Robert S. Hodges, Nir S. Gov, Nicolas Taulier, Wladimir Urbach
JOURNAL OF PHYSICAL CHEMISTRY B
(2010)
Article
Microbiology
Iamara da Silva Andrade, Joao Lidio Vianez-Junior, Carolina Lage Goulart, Fabrice Homble, Jean-Marie Ruysschaert, Wanda Maria Almeida von Krueger, Paulo Mascarello Bisch, Wanderley de Souza, Ronaldo Mohana-Borges, Maria Cristina Machado Motta
Article
Cell Biology
Eva-Maria Krammer, Hayet Saidani, Martine Prevost, Fabrice Homble
Article
Multidisciplinary Sciences
Pierrick Uzureau, Sophie Uzureau, Laurence Lecordier, Frederic Fontaine, Patricia Tebabi, Fabrice Homble, Axelle Grelard, Vanessa Zhendre, Derek P. Nolan, Laurence Lins, Jean-Marc Crowet, Annette Pays, Cecile Felu, Philippe Poelvoorde, Benoit Vanhollebeke, Soren K. Moestrup, Jeppe Lyngso, Jan Skov Pedersen, Jeremy C. Mottram, Erick J. Dufourc, David Perez-Morga, Etienne Pays
Article
Multidisciplinary Sciences
Eva-Maria Krammer, Fabrice Homble, Martine Prevost
Article
Biochemical Research Methods
A. Goldsztein, S. Babar, M. Voue, J. De Coninck, J. Conti, J. Marchand-Brynaert, S. Devouge, F. Homble, E. Goormaghtigh
SPECTROSCOPY-AN INTERNATIONAL JOURNAL
(2010)
Article
Chemistry, Medicinal
Samia Bouzghaya, Mohamed Amri, Fabrice Homble
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Cell Biology
Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homble, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M. La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Soren K. Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Perez-Morga, Etienne Pays
Article
Biochemistry & Molecular Biology
Hayet Saidani, Marc Leonetti, Hanna Kmita, Fabrice Homble
Summary: VDAC is a major pathway for metabolites and ions transport through the mitochondrial outer membrane, regulating solute flow by changing its conductance state. The selectivity inversion of the open state in plant VDAC is influenced by ion concentration and stigmasterol, but may not have a significant physiological effect in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lamia Mlayeh, Eva-Maria Krammer, Marc Leonetti, Martine Prevost, Fabrice Homble
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2017)