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Medicine, Research & Experimental
Allison B. Mason, Melissa L. Lynn, Anthony P. Baldo, Andrea E. Deranek, Jil C. Tardiff, Steven D. Schwartz
Summary: This study utilized computational modeling to predict and simulate the effects of mutations on cardiac thin filament proteins. Experimental validation was used to identify pathogenic signatures and reclassify variants, providing unique structural and dynamic information for classification of both new and conflicting variants.
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Biochemistry & Molecular Biology
Rayner M. L. Queiroz, Sian C. Piper, Johanna S. Rees, Sam Strickson, Emmanuel Briend, Choon Pei Low, G. John Ferguson, Kathryn S. Lilley, Antony P. Jackson, Donna K. Finch
Summary: The ability of the cellular immune system to distinguish self from foreign antigens depends on the calibration of the T cell receptor signaling threshold, which can be affected by interleukin 7 (IL-7). In this study, the researchers investigated the early signaling events triggered by IL-7 and discovered previously unknown transduction events. They found that IL-7 leads to dephosphorylation of cytohesin interacting protein (CYTIP) and alters the co-localization of cytohesin-1 with the TCR and LFA-1 integrin. This study provides insights into the molecular mechanisms underlying TCR activation thresholds and has implications for autoimmune disease therapy and cancer immunotherapy.
BIOCHEMICAL JOURNAL
(2022)
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Physiology
Richard K. Brizendine, Murali Anuganti, Christine R. Cremo
Summary: The study investigates the interactions between myosin and actin at different ATP concentrations and confirms the influence of the flexibility and length of 5S2 on its movement ability. It also proposes the dwell and jump actions of the head region when bound to actin. Results demonstrate that the working heads in the filament can provide sufficient force to overcome the stiffness imposed by filament-S2 interactions.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
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Biochemistry & Molecular Biology
Andrew R. Dunn, Neil M. Kad, Shane R. Nelson, David M. Warshaw, Susan S. Wallace
NUCLEIC ACIDS RESEARCH
(2011)
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Multidisciplinary Sciences
Jessica M. Armstrong, Elena Krementsova, Arthur J. Michalek, Aoife T. Heaslip, Shane R. Nelson, Kathleen M. Trybus, David M. Warshaw
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Andrew T. Lombardo, Shane R. Nelson, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
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Biophysics
Shane R. Nelson, Amy Li, Samantha Beck-Previs, Guy G. Kennedy, David M. Warshaw
BIOPHYSICAL JOURNAL
(2020)
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Physiology
Shane Nelson, Samantha Beck-Previs, Sakthivel Sadayappan, Carl Tong, David M. Warshaw
Summary: Striated muscle is regulated by the super-relaxed state (SRX) of myosin, and the turnover of ATP molecules in cardiac sarcomeres provides insights into the spatial arrangement and regulation of SRX myosin by myosin-binding protein C. The SRX state plays a central role in the metabolic and functional regulation of striated muscle.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
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Biochemistry & Molecular Biology
Christina M. Sorensen, Lea A. Rempel, Shane R. Nelson, Brian R. Francis, David J. Perry, Randolph V. Lewis, Arthur L. Haas, Thomas R. Hansen
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Biochemistry & Molecular Biology
AE Brooks, HB Steinkraus, SR Nelson, RV Lewis