Article
Chemistry, Multidisciplinary
Arivazhagan Rajendran, Kirankumar Krishnamurthy, Seojeong Park, Eiji Nakata, Youngjoo Kwon, Takashi Morii
Summary: DNA minicircles are important for studying DNA-protein interactions, and their topological features play a significant role in these interactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Immunology
Francisco Callejas-Hernandez, Alfonso Herreros-Cabello, Javier del Moral-Salmoral, Manuel Fresno, Nuria Girones
Summary: This study analyzed the complete repertoire of maxicircle and minicircle sequences of different T. cruzi strains, revealing structural differences in minicircles and maxicircles among strains. Understanding the mitochondrial genome of Trypanosomatids is crucial for coordinating the expression of nuclear and mitochondrial genes involved in oxidative phosphorylation, and the heterogeneity observed in minicircles and maxicircles suggests a more complex organization than previously described.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biology
Robert T. Young, Luke Czapla, Zoe O. Wefers, Benjamin M. Cohen, Wilma K. Olson
Summary: DNA carries not only a list of biochemical ingredients but also a multitude of structural and energetic signals that determine its movement and response to proteins and other molecules. By analyzing protein-DNA crystal structures, we can estimate the natural structure and deformability of DNA. Updating the knowledge-based elastic potentials allows for a better understanding of the equilibrium structures and fluctuations of DNA.
Article
Biochemistry & Molecular Biology
Bianca De Sanctis, Daniel Money, Mikkel Winther Pedersen, Richard Durbin
Summary: Many genomic and environmental DNA studies require accurate taxonomic assignment of sequences. However, current methods can lead to incorrect assignments due to various factors. This study developed a theoretical and simulation framework to quantify the impact of population genetic and database parameters on assignment accuracy. The results provide insights into the degradation of accuracy under different conditions and offer a framework for researchers to estimate expected accuracy for their specific methods or parameters.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Geosciences, Multidisciplinary
Harshitha Meda, Chrysafis Vogiatzis, Lauren B. Davis
Summary: Disruptions in airline operations, especially during extreme weather events like hurricanes, have a significant impact on passenger transportation and air travel. Airport network topology and incorporating geospatial elements play a crucial role in efficiently managing and recovering from disruptions. This research proposes a graph theoretical approach that combines topology and geospatial components to identify and classify disrupted airports in an airport network. By analyzing simple paths and developing a rerouting method, the study reveals the weather-related impact on airports and suggests potential alternatives for redirecting passengers from hurricane-affected airports. The computational results highlight the importance of considering geospatial factors and forecasted hurricane tracks in managing airline disruptions.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2023)
Article
Microbiology
Christopher Kay, Lori Peacock, Tom Williams, Wendy Gibson
Summary: Sexual reproduction allows genes from different individuals to be mixed in offspring, which is particularly important for disease-causing microbes. The study found that tsetse-transmitted trypanosomes can produce polyploid hybrids with different genetic traits, impacting the severity of disease outbreaks.
Article
Clinical Neurology
Hua Juan Yang, Hong Mei Wu, Xiao Hui Li, Rui Jin, Lei Zhang, Ting Dong, Xiao Qian Zhou, Bo Zhang, Qiu Juan Zhang, Cui Ping Mao
Summary: The study aimed to investigate changes in the topological organization of whole-brain functional networks in chronic low back pain (CLBP) patients and their relationship with pain characteristics. Graph-theoretical analysis was applied to fMRI data of 33 CLBP patients and 34 healthy controls to construct functional connectivity matrices and extract features of brain networks. The results showed that CLBP patients exhibited altered global and regional network properties, and decreased functional connectivity was observed mainly in the frontolimbic circuit and temporal regions. Moreover, the topological dysfunctions were correlated with pain severity.
Article
Biochemistry & Molecular Biology
Monika Lesicka, Boguslaw Nedoszytko, Edyta Reszka
Summary: This study investigated the relationship between circadian gene expression and immune infiltrations in skin cutaneous melanoma (SKCM) patients. The results showed that many circadian genes have altered expression patterns in SKCM and these gene alterations are associated with decreased overall survival in patients. Additionally, there is a strong correlation between circadian genes and immune cell infiltration. Examining the correlation between circadian rhythm and immune cell infiltration can provide valuable insights into disease progression and guide personalized treatment decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physics, Fluids & Plasmas
Xiang Yang, Sahin Buyukdagli, Alberto Scacchi, Maria Sammalkorpi, Tapio Ala-Nissila
Summary: EP mobility reversal refers to the phenomenon where the direction of polymer drift driven by an external electric field is reversed due to the change in sign of the counterion-dressed surface charge. In order to understand this counterintuitive effect, a strong-coupling-dressed Poisson-Boltzmann approach is applied to the cylindrical geometry of the polyelectrolyte-salt system. The derived analytical polymer mobility formula predicts that the increment of monovalent salt, the decrease of multivalent counterion valency, and the increase of the dielectric permittivity of the solvent suppress charge correlations and increase the concentration of multivalent bulk counterions required for EP mobility reversal. Coarse-grained molecular dynamics simulations support these predictions and show the induction of mobility inversion by multivalent counterions at dilute concentrations.
Article
Engineering, Industrial
Huan Liu, Hirokazu Tatano, Georg Pflug, Stefan Hochrainer-Stigler
Summary: This study uses a temporal, non-homogeneous, Markov process approach to examine the impacts of multiple lifeline service disruptions on business production capacity, with the 2011 Great East Japan Earthquake as a case study. The results suggest that when restoring lifeline systems during disruptions, each individual business service should be taken into consideration, as the restoration of electrical power supply has the most significant influence on improving production capacity for businesses.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2021)
Article
Biochemical Research Methods
Manon Geerts, Achim Schnaufer, Frederik van den Broeck
Summary: Researchers developed rKOMICS, a toolkit for analyzing minicircle sequence diversity in parasitic protozoa, to efficiently manipulate, explore, and extract biologically relevant information from mitochondrial minicircle assemblies in tens to hundreds of samples simultaneously.
BMC BIOINFORMATICS
(2021)
Article
Biology
Emily A. Burger, Inge M. C. M. de Kok, James F. O'Mahony, Matejka Rebolj, Erik E. L. Jansen, Daniel D. de Bondt, James Killen, Sharon J. Hanley, Alejandra Castanon, Mary Caroline Regan, Jane J. Kim, Karen Canfell, Megan A. Smith
Summary: This study evaluated the differential impact of temporary disruptions to primary cervical cancer screening services on women based on their screening history and test modality. The results showed that the disruptions had a greater impact on underscreened women and the main drivers of cervical cancer risk were screening frequency and test modality.
Article
Women's Studies
Sa'diyya Shaikh
Summary: This article explores the destabilizing view of human nature presented by mystical ideas, drawing on the work of thirteenth-century Sufi Ibn Arab. It brings Ibn Arab's ideas into a feminist conversation on gender and argues that his mystical method challenges traditional gender conceptions. The article highlights the importance of paradox, ambivalence, and contradiction in disrupting fixed gender categories. It suggests that a Sufi cosmology demands fluidity and constant movement in critiquing gender hierarchies and heteronormativities within Muslim traditions. The article contributes to the retrieval of a creative and inclusive Muslim archive and connects with broader feminist theories in contemporary scholarship.
Article
Engineering, Civil
Wen-Long Shang, Ziyou Gao, Nicolo Daina, Haoran Zhang, Yin Long, Zhiling Guo, Washington Y. Ochieng
Summary: This study proposes a new method, Relative Area Index (RAI), to quantify the robustness of multi-scale urban road networks (URNs) and compares it with a traditional topological metric. The results show that RAI is more effective in capturing the impact of realistic network characteristics and highlights the importance of central management when URNs suffer from disruptions.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Green & Sustainable Science & Technology
Can Ding, Li Liu, Yi Zheng, Jianxiu Liao, Wenxing Huang
Summary: The convergence of physical stores and e-commerce has led to the emergence of a new retail business mode. This paper analyzes the effects of supply chain node disruptions on new retail supply chain performance and service level, with the warehouse center disruption having the most devastating effect.
