期刊
BIOPHYSICAL JOURNAL
卷 95, 期 6, 页码 2624-2635出版社
CELL PRESS
DOI: 10.1529/biophysj.108.132167
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资金
- Howard Hughes Medical Institute
- National Institutes of Health (NIH) [GM068630]
- Center for Theoretical Biological Physics [PHY0225630]
- NIH [RR004050, NS046068, NS014718]
- National Science Foundation [MCB0543934, GM065937]
- Center for Computational Science at Tulane University [NIH 1 P20 EB001432-01]
A computational model is presented for the simulation of three-dimensional electrodiffusion of ions. Finite volume techniques were used to solve the Poisson-Nernst-Planck equation, and a dual Delaunay-Voronoi mesh was constructed to evaluate fluxes of ions, as well as resulting electric potentials. The algorithm has been validated and applied to a generalized node of Ranvier, where numerical results for computed action potentials agree well with cable model predictions for large clusters of voltage-gated ion channels. At smaller channel clusters, however, the three-dimensional electrodiffusion predictions diverge from the cable model predictions and show a broadening of the action potential, indicating a significant effect due to each channel's own local electric field. The node of Ranvier complex is an elaborate organization of membrane-bound aqueous compartments, and the model presented here represents what we believe is a significant first step in simulating electrophysiological events with combined realistic structural and physiological data.
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