Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

(2011) Helen E. Cubitt et al.   XENOBIOTICA

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

(2010) Y. Chen et al.   DRUG METABOLISM AND DISPOSITION

Comparison between recombinant P450s and human liver microsomes in the determination of cytochrome P450 Michaelis–Menten constants

(2010) K. Youdim et al.   XENOBIOTICA

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

(2009) R. A. Stringer et al.   DRUG METABOLISM AND DISPOSITION

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Reaction Phenotyping: Current Industry Efforts to Identify Enzymes Responsible for Metabolizing Drug Candidates

(2008) Timothy W. Harper et al.   AAPS Journal

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

(2008) Kuresh A. Youdim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION

Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance

(2008) R. Stringer et al.   XENOBIOTICA