期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 3, 页码 923-927出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.12.073
关键词
Cancer; Apoptosis resistance; Melanoma; Glioblastoma; Alkaloid
资金
- Texas State University
As a continuation of the studies aimed at the development of new anticancer agents derived from the Amaryllidaceae alkaloid lycorine, 35 C1, C2-ether analogues of this natural product were synthesized. The compounds were evaluated for antiproliferative activities in vitro in a panel of tumor cell lines with varied levels of apoptosis resistance. A strong correlation between the compound lipophilicity and anticancer activity was observed, indicating that cell permeability properties must be an important determinant in the design of lycorine-based anticancer agents. A theoretical docking model, consistent with the experimental observations, is presented. (C) 2013 Elsevier Ltd. All rights reserved.
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