期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 4, 页码 1154-1157出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.12.121
关键词
Ring-expanded nucleosides; Imidazo[4,5-e][1,3] diazepines; Organic synthesis; Antiviral compounds; In vitro screening; Hepatitis C virus (HCV); Human immunodeficiency virus (HIV); Dual inhibitors of HCV and HIV; Inhibition of HCV NTPase/helicase; Inhibition of RNA helicase DDX3
资金
- National Institute of General Medical Sciences, of the National Institutes of Health [1R01 GM087738-01A1, 1 R21 AI071802]
- National Institute of Allergy & Infectious Diseases, of the National Institutes of Health
Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3. Since HCV is a leading co-infection in late stage HIV AIDS patients, often leading to liver cirrhosis and death, the observed dual inhibition of HCV and HIV by the target nucleoside analogues has potentially beneficial implications in treating HIV patients infected with HCV. (C) 2014 Elsevier Ltd. All rights reserved.
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