期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 6, 页码 1605-1610出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.01.035
关键词
Thieno[3,2-c] pyridine; Antileishmanial activity; L. donovani promastigotes; Antimicrobial activity; Docking study; ADME properties
A series of N '-substitutedbenzylidene-2-(6,7-dihydrothieno[ 3,2-c] pyridin-5(4H)-yl) acetohydrazide derivatives is synthesized and evaluated for antileishmanial activity against Leishmania donovani promastigotes. Compounds 9a and 9i were shown significant antileishmanial when compared with standard sodium stilbogluconate. Antimicrobial study revealed that compound 9b has potent as well as broad spectrum antibacterial activity when compared with ampicillin and compound 9e showed promising antifungal activity when compared with miconazole. Also, none of the synthesized compounds showed cytotoxicity up to tested concentration. Further, docking study against pteridine reductase 1 enzyme of L. donovani showed good binding interactions. ADME properties of synthesized compounds were also analyzed and showed potential to develop as good oral drug candidates. (C) 2014 Elsevier Ltd. All rights reserved.
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