期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 5, 页码 1426-1431出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.01.006
关键词
Amide derivatives; Hedgehog; Smoothened antagonist
资金
- China Postdoctoral Science Special Foundation [201104690]
A series of novel benzamide derivatives were prepared and evaluated using cell-based measurements. Among these compounds, 10f significantly inhibited Hedgehog signaling and showed equivalent or more potency than GDC-0449 in different tests. Furthermore, compound 10f potently inhibited the proliferation of Daoy, a medulloblastoma cell line that is reported to be resistant to GDC-0449, which indicated a promising prospect in the treatment of Hedgehog signaling pathway related cancer in clinical trial. (C) 2014 Elsevier Ltd. All rights reserved.
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