期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 7, 页码 1724-1729出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.02.042
关键词
Amides; Polyether ionophores; Anticancer properties; Antibacterial activity; Natural compounds
资金
- Polish National Science Centre (NCN) [2011/03/D/ST5/05884]
A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE). (c) 2014 Elsevier Ltd. All rights reserved.
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