期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 16, 页码 3907-3913出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.06.047
关键词
9-Aryl-hexahydro-acridine-1,8-diones; Aromatic aldehydes; Dimedone; Ammonium acetate; Silica iodide; Anticancer activity
资金
- UGC, New Delhi
- Bangalore University
- VGST, Dept. of IT, BT and Science & Technology, Government of Karnataka [24]
A simple, efficient and cost-effective method for the synthesis of 9-aryl-hexahydro-acridine-1,8-diones by a one-pot four-component cyclocondensation of dimedone, aromatic aldehydes and ammonium acetate as a nitrogen source in the presence of a new heterogeneous catalyst silica iodide (SiO2-I) in EtOH at 80 degrees C is described. SiO2-I was subjected to SEM-EDX and found to have iodo group bound to the catalyst. Some of the prepared acridine-diones were found to exhibit promising anti-cancer activity against HepG2 and MCF-7 cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
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