期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 16, 页码 3865-3868出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.06.054
关键词
18 beta-Glycyrrhetinic acid; Triazole; Carbohydrate; Click chemistry; Anticancer agent
资金
- CSIR, New Delhi
- CSIR, New Delhi [02(0038)/11/EMR-II (AKM)]
- Bose Institute
A series of glycosyl triazol linked 1 beta-glycyrrhetinic acid (GA) derivatives have been synthesized using 1,3-dipolar cycloaddition reaction of per-O-acetylated glycosyl azide derivatives (4a-h) with propargyl ester of 18 beta-glycyrrhetinic acid (GA) (2 and 3) following the concept of 'Click chemistry'. The synthesized triazole derivatives were de-O-acetylated to furnish compounds (7a-h and 8a-c) with free hydroxyl groups in the carbohydrate moieties, which were evaluated for their anticancer potential against human cervical cancer cells (HeLa) and normal kidney epithelial (NKE) cells. GA (1), compound 7d, compound 7g and compound 8c showed promising anticancer activities. (C) 2014 Elsevier Ltd. All rights reserved.
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