期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 12, 页码 2645-2647出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.04.071
关键词
Malaria; Pohlianin; Cyclic peptide; Natural product; Jatropha
资金
- The University of Sydney
- UNSW Australia for a Faculty of Science Research Grant
- Australian Research Council for a Discovery Early Career Researcher Award
- Australian Research Council [LP120200557]
- Australian Red Cross Blood Service
- Australian Research Council [LP120200557] Funding Source: Australian Research Council
The first synthesis of the glycine-rich cyclic octapeptide pohlianin C is reported, confirming the structure of this natural product. Screening against Plasmodium falciparum reveals moderate antiplasmodial activity, consistent with data obtained from the natural sample. In addition, the synthesis of three analogues reveals that the antiplasmodial activity of pohlianin C can be preserved or increased with simplified structures. (C) 2014 Elsevier Ltd. All rights reserved.
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