Article
Materials Science, Multidisciplinary
Alex Yang-Hao Yu, Ru-Huei Fu, Shan-hui Hsu, Chen-Feng Chiu, Wei-Hsiang Fang, Chun-An Yeh, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Utilizing collagen gold nanoparticles as a carrier for EGFR siRNA shows promising results in treating lung cancer, leading to significant tumor suppression effects and improved survival rates.
MATERIALS TODAY ADVANCES
(2021)
Article
Oncology
Yoshitaka Saito, Kazuki Uchiyama, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara
Summary: A retrospective evaluation of mCRC patients receiving anti-EGFR monoclonal antibody treatment identified liver metastasis as an independent risk factor for skin toxicities and prophylactic administration of antibiotics as a preventive factor. The study suggests that preemptive antibiotic use can decrease the risk of skin toxicities during anti-EGFR treatment.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Chemistry, Multidisciplinary
Jing Zhao, Siying Li, Xuelei Pang, Yuping Shan
Summary: The therapeutic efficacy of nano-drugs targeting EGFR was evaluated in terms of cell entry efficiency and induced cell mechanical properties at the single particle/cell level in real time.
CHEMICAL COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasper Vonk, Jaron G. de Wit, Floris J. Voskuil, Yang Hang Tang, Wouter T. R. Hooghiemstra, Matthijs D. Linssen, Evert van den Broek, Jan J. Doff, Sebastiaan A. H. J. de Visscher, Kees-Pieter Schepman, Bert van der Vegt, Gooitzen M. van Dam, Max J. H. Witjes
Summary: This study investigated the use of fluorescence imaging to detect lymph node metastases in oral cancer patients. The results showed that fluorescence molecular imaging could accurately detect tumor-positive lymph nodes, reducing the need for microscopic assessment and identifying additional metastases missed by standard histopathologic analysis.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Ryuhei Okada, Takuya Kato, Aki Furusawa, Fuyuki Inagaki, Hiroaki Wakiyama, Daiki Fujimura, Shuhei Okuyama, Hideyuki Furumoto, Hiroshi Fukushima, Peter L. Choyke, Hisataka Kobayashi
Summary: This study compared the effects of Panitumumab and Cetuximab in APCs for NIR-PIT and the impact of different light exposure regimens on tumor growth in an immunocompetent mouse model. The results showed that APCs with longer half-life and double light exposure had superior outcomes in cancer cell-targeted NIR-PIT.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Oncology
Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi
Summary: This study demonstrated that gold nanoparticles can enhance the sensitivity of head and neck squamous cell carcinoma to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.
Article
Biochemistry & Molecular Biology
Hyunjun Ko, Mi-Jin Kim, Hyun Joo Park, Jung-Hoon Sohn, Jung-Hoon Bae
Summary: Human epidermal growth factor (hEGF) has potential applications due to its wide range of physiological functions, but its low stability limits its effectiveness. This study developed stable hEGF delivery system using levan-based nanoparticles. The CML-hEGF nanoparticles showed high entrapment yield, size of 199.9+/- 3.87 nm, zeta potential of -19.1 mV, and dual biological functions of skin regeneration and moisturizing. These nanoparticles maintained cell proliferation activity for 6 weeks, highlighting their potential in pharmaceutical and cosmeceutical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Dongshao Chen, Ruoxi Hong, Youjun Cao, Qingnan Wu, Yan Wang, Jie Chen, Jinting Li, Weimin Zhang, Qimin Zhan
Summary: This study found that dual blockage of EGFR and Wee1 inhibited tumor growth in ESCC partially through PI3K/Akt or MAPK pathway blockade and inducing apoptosis. Meanwhile, the POLR2A might be candidate molecule of EGFR/Wee1 downstream.
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Lina S. Silva-Bermudez, Tatyana N. Sevastyanova, Christina Schmuttermaier, Carolina De La Torre, Leonie Schumacher, Harald Klueter, Julia Kzhyshkowska
Summary: Titanium nanoparticles (TiNPs) have a dual effect on the GDF-15/stabilin-1 interaction in macrophage system, by increasing the production of GDF-15 and suppressing stabilin-1-mediated clearance function. This can lead to unbalanced pro-fibrotic reactions and implant complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Muammer Y. Yaman, Kathryn N. Guye, Maxim Ziatdinov, Hao Shen, David Baker, Sergei Kalinin, David S. Ginger
Summary: The study found that gold nanorods tend to align parallel to protein nanofibers, with this preference decreasing as salt concentration increases. Increase in specific gold nanorod attachment density with solution ionic strength is primarily dominated by non-specific binding to the substrate background.
Article
Biochemistry & Molecular Biology
Ralph El Hallal, Nana Lyu, Yuling Wang
Summary: The study demonstrates that cetuximab-conjugated gold nanoparticles exhibit cytotoxic effects on colorectal cancer cells and alter the expression of related biomarkers on cancer cell surfaces. Gold nanoparticles with a size of 60 nm showed the greatest cytotoxic impact, while treatment with cetuximab-AuNPs resulted in increased heterogeneity in the expression of surface biomarkers. Both surface-enhanced Raman scattering/spectroscopy (SERS) and flow cytometry confirmed the correlation between the cell surface biomarkers and drug treatment, suggesting a potential for drug-conjugated AuNPs to enhance cancer prognosis and therapy.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)