期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 12, 页码 3604-3608出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.013
关键词
Nelumbo nucifera; Nymphaeaceae; Nelumnucifosides A and B; Pancreatic lipase; Adipocyte differentiation
资金
- National Institute of Biological Resource (NIBR) through Ministry of Environment
- Basic Science Research Program through the National Research Foundation of Korea [2012-0008023]
- Medical Research Center Program through the National Research Foundation of Korea [2010-0029480]
Nelumbo nucifera Gaertn. (Nymphaeaceae), commonly called lotus, is widely distributed throughout Eastern Asia. It has been used for food and medicine for a long time. A phytochemical investigation of N. nucifera leaves led to the isolation of 13 megastigmanes (1 -13), including a new megastigmane, nelumnucifoside A (1), and a new eudesmane sesquiterpene, nelumnucifoside B (14), eight alkaloids (15-22), and 11 flavonoids (23-33). Their chemical structures were determined based on spectroscopic methods including 1D, 2D NMR and MS spectrometry. The relative and absolute stereochemistry of the compounds was determined by NOESY and CD spectrometry, respectively. Compounds 19 and 22 significantly inhibited pancreatic lipase, whereas compounds 15 and 16 showed a strong inhibitory effect on adipocyte differentiation. Therefore, the leaves of N. nucifera have potential as an anti-obesity agent by inhibiting pancreatic lipase and adipocyte differentiation. (C) 2013 Elsevier Ltd. All rights reserved.
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