期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 13, 页码 3910-3913出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.062
关键词
D-Amino acid oxidase; Flavoenzyme; Kojic acid; Schizophrenia
资金
- National Institutes of Health [R01MH091387]
- Johns Hopkins Brain Science Institute NeuroTranslational Drug Discovery program
A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. (c) 2013 Elsevier Ltd. All rights reserved.
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