期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 17, 页码 5527-5531出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.07.030
关键词
Anti-tumor activity; Desferrioxamine; Iron chelation
资金
- TWING fellowship
- NCN grant [DEC-2011/01/N/NZ4/01166, N405/068440]
- UPGOW fellowship
- Dokto-RIS studentship
- Polish Ministry of Science [R 0504303]
- NHMRC
- ARC Discovery Grant
- Sydney Medical School of the University of Sydney
- Cancer Institute New South Wales Early Career Development Fellowship and Innovation Grant
Iron chelators have emerged as a potential anti-cancer treatment strategy. In this study, a series of novel thiosemicarbazone iron chelators containing a quinoline scaffold were synthesized and characterized. A number of analogs show markedly greater anti-cancer activity than the 'gold-standard' iron chelator, desferrioxamine. The anti-proliferative activity and iron chelation efficacy of several of these ligands (especially compound 1b), indicates that further investigation of this class of thiosemicarbazones is worthwhile. (C) 2012 Elsevier Ltd. All rights reserved.
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