Article
Multidisciplinary Sciences
Hadi Aqel Khdera, Sawsan Youseff Saad, Aoula Moustapha, Farouk Kandil
Summary: A new route for the synthesis of chalcone and its derivatives was developed, and the physical and spectroscopic properties of the synthesized compounds were studied. The biological activity of some compounds against three types of fungi was also investigated, showing promising results.
Article
Spectroscopy
Marco Mellado, Rafaela Sariego-Kluge, Franco Valdes-Navarro, Cesar Gonzalez, Rodrigo Sanchez-Gonzalez, Nancy Pizarro, Joan Villena, Carlos Jara-Gutierrez, Claudio Cordova, Manuel A. Bravo, Luis F. Aguilar
Summary: In this study, 11 new fluorescent pigments were synthesized and their photophysical properties were analyzed. It was found that the chemical structure of the compounds plays a crucial role in determining their properties. The compounds were also applied as fluorescent pigments in living cell imaging, with compound 12a showing potential as an alternative.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Nitish Deshpande, Jee-Yee Chen, Takeshi Kobayashi, Eun Hyun Cho, Hannah Pineault, Li -Chiang Lin, Nicholas A. Brunelli
Summary: This study investigates the impact of micropores on the catalytic activity of aminosilica materials. By comparing materials with micropores and materials with negligible micropore volume, it is found that the materials with negligible micropore volume exhibit higher catalytic activity in a range of reactions.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Physical
Fangliang Li, Binli Wang, Xiao Chen, Hongjun Fan, Xueming Yang, Qing Guo
Summary: The study shows that the R-TiO2(100)-(1 x 1) surface exhibits high reactivity and selectivity for aldol condensation of unbranched aldehydes at room temperature. The low energy barriers for enolization and dehydration reactions, along with stable adsorption of intermediates, contribute to the surface's efficiency in forming crotonaldehyde. The exclusive selectivity of (E)-crotonaldehyde formation is attributed to the adsorption configuration of CH3CHO and surface structure of R-TiO2(100)(1 x 1).
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Ruiyi Yan, Zhaopo Lv, Hongguo Tang, Yinge Bai, Mengyue Li, Yuchao Li
Summary: The study utilized diethylammonium acetate as a catalyst to achieve a high conversion rate of 99.9% from propionaldehyde to methacrolein, with a selectivity of 97.4%. Isotopic tracing experiments and decreasing the reaction temperature were used to propose a possible reaction mechanism.
Article
Multidisciplinary Sciences
Shima Nasri, Mohammad Bayat, Fatemeh Rostami Miankooshki
Summary: A novel multi-component reaction was developed for the synthesis of diverse spiro-imidazo pyridine-indene derivatives. The reaction involved heterocyclic ketene aminals reacting with bindone, using malononitrile as a promoter or as one of the precursors. The convenient one-pot operation, high substrate diversity, and presence of active sites in the synthesized products are attractive features of this approach.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Xianglong Meng, Hui Su, Ranran Song, Jianzheng Su, Junjie Bian
Summary: The use of thermochemical methods to convert biomass resources into high-value fuels and chemicals has gained popularity in energy utilization. In this study, natural minerals were modified through ball-milling to introduce acidic sites, and a solvent-free aldol condensation reaction of biomass-based cyclopentanone was carried out. The results demonstrated that the SO3H-APG catalyst with a -SO3H loading of 4 mmol/g showed excellent acid-base co-activation effects and catalytic effect in the condensation reaction. The optimized reaction conditions achieved a 85.53% conversion of cyclopentanone at a reaction temperature of 150 degrees Celsius and reaction time of 4 h. The dimer and trimer selectivity were 69.04% and 28.41%, respectively. Moreover, the analysis revealed that the presence of an acid-base bifunctional catalyst was crucial for the condensation reaction and this research offers a promising pathway for catalyst design and the synthesis of long-chain hydrocarbons.
Article
Chemistry, Organic
Daan V. Bunt, Sahar El Aidy, Adriaan J. Minnaard
Summary: The meroterpenoids fornicin A, fornicin D, and ganodercin D found in mushrooms of the Ganoderma genus were synthesized through a concise and divergent route. The unsaturated gamma-ketoacid moiety was obtained via an optimized step-wise aldol condensation. Additionally, a protocol for THP-protection of a phenolic hydroxyl group under basic conditions was developed, adding to the versatility of this protecting group.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vanessa Brito, Adriana Oliveira Santos, Gilberto Alves, Paulo Almeida, Samuel Silvestre
Summary: A series of novel 21E-arylidene-4-azapregn-5-ene steroids were successfully designed and synthesized. Their antiproliferative activity in four different cell lines was evaluated. Among them, the 21E-(pyridin-3-yl)methylidene derivative showed significant cytotoxic activity in hormone-dependent cells LNCaP and T47-D. The steroid 21E-p-nitrophenylidene-4azapregn-5-ene exhibited the highest potency in androgen-independent cells PC-3. Further biological studies on T47-D and LNCaP cells revealed that the azasteroid led to apoptotic death in T47-D cells. Molecular docking studies showed that the compounds had higher affinity for 5 alpha-reductase type 2 and estrogen receptor alpha.
Article
Biochemistry & Molecular Biology
Ana Donaire-Arias, Martin L. Poulsen, Jaime Ramon-Costa, Ana Maria Montagut, Roger Estrada-Tejedor, Jose I. Borrell
Summary: Chalcones, a type of molecule that can be easily synthesized through aldol condensation, lacks standard procedures and often yields low purity and low yields. By comparing aldol condensation and Wittig reaction, the improved procedure of Wittig reaction shows high yield and excellent purity, providing a novel method for the synthesis of chalcones.
Article
Chemistry, Physical
Jee-Yee Chen, Hannah Pineault, Nicholas A. Brunelli
Summary: This study investigates the catalytic activity of aminosilica materials on a per site basis and reveals four types of catalytic sites. The results suggest a cooperative interaction between amines and different types of silanols at high activity sites, offering the potential to create highly active catalytic materials.
JOURNAL OF CATALYSIS
(2022)
Article
Engineering, Chemical
Qiu Zhao, Gang Wang, Fuxia Liao, Yifan Sha, Fei Xu, Chunshan Li, Zengxi Li, Yijun Cao
Summary: An ionic liquid (IL) catalyzed solvent-free process was developed for the direct synthesis of chalcone and its derivatives, with [Bmim]OH identified as the optimal IL with the highest yield and selectivity reaching up to 96.7% and 100%, respectively. A reaction mechanism-based kinetic model was established and regressed with experimental data, revealing the rate-controlling step as the beta-Hydroxylketone dehydrolysis with an activation barrier of 37.8 kJ.mol(-1).
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Penghui Dong, Kashif Majeed, Lingna Wang, Zijian Guo, Fengtao Zhou, Qiuyu Zhang
Summary: A transition metal-free aldol condensation/[1+2+3] annulation reaction has been developed for the general synthesis of azafluoranthenes, enabling the formation of three new bonds and two rings in a single operation. This methodology can also be used to construct chromeno[4,3-c]pyridines and benzo[c][2,6]naphthyridines in moderate yields.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Gurmeet Kaur, Mandeep Kaur, Manisha Bansal
Summary: Studies have shown that curcumin and its analogues have potential value in anti-cancer activity, attracting the attention of many researchers. Natural products such as curcumin, rosmarinic acid and chalcone have positive effects on cancer prevention and treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo
Summary: The study found that AN07 significantly attenuated inflammation in LPS-treated muscle cells, improved mitochondrial function, and showed protective effects against myotube atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: AKT serine-threonine kinase and its effectors play essential roles in maintaining various cellular functions of cancer cells, while lncRNAs and circRNAs regulate the expression of these functions through multiple pathways. This review provides comprehensive information about the relationship between lncRNAs, circRNAs, and AKT in the regulation of cancer cell functions.
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Oxidative stress and AKT pathway play crucial roles in regulating various cell functions in cancer cells. Natural products have the potential to modulate oxidative stress and AKT for anticancer effects. However, the underlying mechanisms of how they regulate cell functions, particularly the contribution of AKT downstream effectors, are not well understood. This review discusses the roles of oxidative stress and AKT pathway in ten cell functions and highlights the potential of natural products in regulating these functions, with a focus on AKT effectors that have been rarely reported.
Article
Biochemistry & Molecular Biology
Chi-Jen Tai, Chih-Hua Chao, Atallah F. Ahmed, Chia-Hung Yen, Tsong-Long Hwang, Fang-Rong Chang, Yusheng M. Huang, Jyh-Horng Sheu
Summary: Chemical investigation of the Red Sea sponge Spongia sp. resulted in the discovery of four new compounds, secodinorspongins A-D (1-4), as well as a known compound sponginolide (5). The structures of these compounds and their absolute configurations were elucidated using spectroscopic methods and a comparison of calculated and experimental CD spectra. A possible biosynthetic pathway for compounds 1-4 was proposed. The cytotoxic, antibacterial, and anti-inflammatory activities of compounds 1-5 were also evaluated, with compound 1 showing inhibitory activity against Staphylococcus aureus growth, and compounds 4 and 5 suppressing superoxide-anion generation and elastase release in human neutrophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yen Chi Loo, Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Michal Korinek, Yang-Chang Wu, Fang-Rong Chang, Ying-Jung Chen
Summary: In this study, the anti-aging potential of Cosmos caudatus Kunth (CC) extracts and fractions was investigated. It was found that these extracts and fractions inhibited collagenase, MMP-1, and MMP-3 activities in human dermal fibroblasts and contained flavonoid glycosides as the major compounds. These findings suggest that CC has the potential to be developed as anti-aging products.
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Article
Chemistry, Medicinal
Minh Tuyet Thi Nguyen, I-Chi Hsu, Hui-Kang Liu, Yu-Chi Lin, Shu-Rong Chen, Fang-Rong Chang, Yuan-Bin Cheng
Summary: A phytochemical investigation of Glycosmis pentaphylla collected in Vietnam resulted in the discovery of three new compounds and twenty-five known compounds. The structures of the isolates were determined through various analytical methods. In the screening for anti-diabetic activity, several compounds showed potential inhibition of DPP4 and stimulation of GLP-1 secretion.
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Jen-Yang Tang, Hsueh-Wei Chang
Summary: This review aims to elucidate the relationship between natural products, miRNAs, and the AKT pathway in cancer cell development. By identifying the connections between miRNAs and the AKT pathway, as well as miRNAs and natural products, an miRNA/AKT/natural product axis was established to facilitate a better understanding of their anticancer mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hsien-Kuo Chin, Mei-Chin Lu, Kai-Cheng Hsu, Mohamed El-Shazly, Tsen-Ni Tsai, Tzu-Yung Lin, Shou-Ping Shih, Tony Eight Lin, Zhi-Hong Wen, Yu-Chen S. H. Yang, Yi-Chang Liu
Summary: 13-AC is a compound derived from coral that can induce apoptosis in human acute lymphoblastic leukemia cells. It acts as a dual inhibitor of heat shock protein 90 and topoisomerase IIa, leading to its cytotoxic effects.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Oncology
Ya-Ting Chuang, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Fang-Rong Chang, Yi-Hong Tsai, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Cancer cells release exosomes containing tumor-promoting effects, and natural products can block exosome processing and inhibit cancer progression. However, the correlation between exosomal lncRNAs and natural product treatments is not well understood. By using bioinformatics, this study fills the gap by exploring the interaction between exosomal lncRNAs, miRNAs, and exosomal processing genes, and summarizes their roles in cancer progression and the anticancer effects of natural products.
Article
Biochemistry & Molecular Biology
Wei-Cheng Yuan, Tung-Ying Wu, Pei-Yi Chu, Fang-Rong Chang, Yang-Chang Wu
Summary: An efficient method for preparing bioactive ingredient 3S,3 ' S-astaxanthin (3S,3 ' S-AST) from genetically modified yeast was developed. The combination of enzyme-assisted extraction and salt-assisted liquid-liquid extraction (SALLE) resulted in a high yield of 3S,3 ' S-AST with over 99% purity. The antioxidant capacity of the purified 3S,3 ' S-AST products was found to be 18.3 times higher than that of the original raw material extract. This new method has the potential to replace previous methods and can be scaled up for the production of high-purity 3S,3 ' S-AST with lower cost and simpler equipment in the food and/or drug industries.
Article
Environmental Sciences
Sih-Syuan Li, Jia-Jen Chen, Ming-Wei Su, Chien-Wei Lin, Chu-Chih Chen, Yin-Han Wang, Chia-Chu Liu, Yi-Chun Tsai, Tusty-Jiuan Hsieh, Ming-Tsang Wu, Chia-Fang Wu
Summary: Taiwan has a high incidence of chronic kidney disease (CKD), and this study examined the associations between daily exposure to phthalates and melamine, two common nephrotoxins, and the risk of kidney damage. The study used data from the Taiwan Biobank and found a significant positive association between the daily intake levels of melamine and phthalates and the urine microalbumin to creatinine ratio (ACR). This association was particularly prominent in men.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yi-Chun Tsai, Chia-Fang Wu, Wei-Wen Hung, Ping-Shaou Yu, Chia-Chu Liu, Tusty-Jiuan Hsieh, Chu-Chih Chen, Sih-Syuan Li, Jia-Jen Chen, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Tsang Wu
Summary: This prospective cohort study investigated the impact of melamine exposure on kidney outcomes in type 2 diabetes mellitus (T2D) patients. The findings showed a significant association between melamine exposure and adverse kidney outcomes in T2D patients, especially in those with male, well sugar control or good baseline kidney function.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Yi-Hong Tsai, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: This review focuses on the regulating effects of natural products on miRNAs to assess the potential impacts of radiomodulation and exosome biogenesis for both the radiosensitization of cancer cells and the radioprotection of non-cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Heba A. S. El-Nashar, Mohamed Taleb, Mohamed EL-Shazly, Chao Zhao, Mohamed A. Farag
Summary: This review comprehensively discusses the antidiabetic effects and mechanisms of action of major soluble dietary fibers (SDF), which can aid in the development of novel natural antidiabetic drugs from SDF.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
