Review
Chemistry, Medicinal
Nancy Saini, Ritika Sirohi, A. Anuradha, Neetu Saini, Pankaj Wadhwa, Paranjeet Kaur, Vikas Sharma, Gurdeep Singh, Iqubal Singh, Sanjeev Kumar Sahu
Summary: Cancer is a deadly disease that is increasing in prevalence due to changes in lifestyle, nutrition, and global warming. About 60% of FDA-approved cancer medicines are derived from natural ingredients. Recent efforts to exploit the chemical diversity of marine life have led to the discovery of potential anticancer treatments. This review discusses the molecular targets of marine products as anticancer drugs and the compounds that have shown activity against these targets.
MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Kaori Ozaki, Yuka Asato, Noriyuki Natsume, Shunya Tojo, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from a marine cyanobacterium called Okeania. Their structures were determined using spectroscopic analyses and their absolute configurations were elucidated through a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) were found to dose-dependently promote the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Kaori Ozaki, Atsuhide Jinno, Noriyuki Natsume, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: In this study, the linear lipopeptides komesuamide and odopenicillatamide were isolated from the marine cyanobacterium Caldora penicillata collected in Okinawa. The structures of these compounds were determined by spectroscopic analyses and their absolute configurations were established by HPLC analyses of the acid hydrolysates. Both compounds exhibited glucose uptake activity at 40 mM in cultured L6 myotubes.
Article
Chemistry, Multidisciplinary
Sandra A. C. Figueiredo, Marco Preto, Gabriela Moreira, Teresa P. Martins, Kathleen Abt, Andre Melo, Vitor M. Vasconcelos, Pedro N. Leao
Summary: The study utilizes the lack of functional beta-oxidation pathway in cyanobacteria to efficiently stable-isotope-label their fatty acid derived lipidome by supplementing with deuterated fatty acids, enabling easy detection of natural product signatures. This strategy has been successfully demonstrated in two cultured cyanobacteria, leading to the discovery of analogues of the multidrug-resistance reverting hapalosin and novel, cytotoxic lactylate-nocuolin A hybrids - the nocuolactylates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Oncology
Myat Nyein Khine, Kaori Sakurai
Summary: The Golgi apparatus is a vital cellular component involved in maintaining cell homeostasis, biosynthesis of glycans, lipids, and modified proteins, as well as sorting and transport of proteins. It also serves as a signaling hub for cellular response pathways. Disturbances in Golgi signaling are implicated in tumor growth and survival regulation. Identification of Golgi-targeting natural products with anticancer properties has allowed for the characterization of Golgi-mediated signaling events leading to cancer cell death, and suggests potential for developing novel chemotherapeutic agents by selectively exploiting these pathways.
Review
Biochemistry & Molecular Biology
Jindra Valentova, Lucia Lintnerova, Natalia Miklasova, Bianka Obonova, Ladislav Habala
Summary: Life is chiral, and the chiral discrimination of molecules plays an important role in medicinal chemistry. Different enantiomers of chiral compounds can have different effects in terms of pharmacodynamics, pharmacokinetics, and toxicity. The use of only one enantiomer can enhance the bioactivity of a drug and reduce adverse effects. This is particularly significant in natural products, as most of them contain chiral centers. This survey discusses the impact of chirality on anticancer chemotherapy and focuses on the recent developments in this area, particularly synthetic derivatives of natural drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Dimpy Rani, Vandana Garg, Rohit Dutt
Summary: This review discusses the potential of natural products containing azole nucleus from marine sources in anticancer research, aiming to encourage the scientific community to explore marine resources for developing novel and potent azole-containing anti-cancer agents with better safety profiles.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Akira Ebihara, Arihiro Iwasaki, Youhei Miura, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: The new polyhalogenated aryl sulfates, Bromoiesol sulfates A and B, were isolated from a marine cyanobacterium and their structures were elucidated using Small Molecule Accurate Recognition Technology and X-ray diffraction analysis. Total synthesis of Bromoiesol A sulfate and Bromoiesol A was achieved, and their inhibitory effects on Trypanosoma brucei rhodesiense were confirmed.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Miah Roney, Abdul Rashid Issahaku, Akm Moyeenul Huq, Mahmoud E. S. Soliman, Saiful Nizam Tajuddin, Mohd Fadhlizil Fasihi Mohd Aluwi
Summary: The aim of this study is to discover more promising anti-cancer compounds against EGFR from marine natural products using computational approaches. Through molecular docking and drug-likeness analysis, phenolic acids with good binding energies and pharmacokinetics profiles were identified. Molecular dynamics simulation revealed the stability of the lead complex, suggesting its potential as a future drug for cancer treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Dario Matulja, Filip Vranjesevic, Maria Kolympadi Markovic, Sandra Kraljevic Pavelic, Dean Markovic
Summary: Marine organisms produce diverse secondary metabolites with various biological activities, including anticancer effects. Marine phenolic compounds and their derivatives have been studied for their potential anticancer activity. These compounds inhibit cancer cell proliferation or migration at sub-micromolar or nanomolar concentrations. They exert their anticancer effects through different mechanisms, such as apoptosis induction or inhibition of cell migration. Phenolic compounds like phlorotannins and bromophenols have been extensively studied and recognized for their protective effects against UVB or gamma radiation-induced skin damage. Phenolic metabolites can be classified into six main classes.
Review
Pharmacology & Pharmacy
Federico Cerri, Marco Giustra, Yaprak Anadol, Giulia Tomaino, Paolo Galli, Massimo Labra, Luca Campone, Miriam Colombo
Summary: The exploration of natural extracts for pharmaceutical applications, especially plant extracts, is a promising area of medical research. Avicennia marina has been identified as a potential source of natural substances with strong anti-cancer activity. Formulating A. marina extracts into nanoparticles can enhance selectivity towards cancer cells and reduce side effects.
Article
Chemistry, Medicinal
Tiago Leao, Mingxun Wang, Nathan Moss, Ricardo da Silva, Jon Sanders, Sergey Nurk, Alexey Gurevich, Gregory Humphrey, Raphael Reher, Qiyun Zhu, Pedro Belda-Ferre, Evgenia Glukhov, Syrena Whitner, Kelsey L. Alexander, Robert Rex, Pavel Pevzner, Pieter C. Dorrestein, Rob Knight, Nuno Bandeira, William H. Gerwick, Lena Gerwick
Summary: This study focuses on describing the natural product genetic potential and expressed natural product molecules in benthic tropical cyanobacteria, utilizing a multi-omics approach. Results indicate that despite the presence of genes encoding for peptidic natural products, peptides are not as abundant as lipids and lipopeptides in the chemical extracts. The study highlights promising biosynthetic gene clusters for genome mining among these cyanobacterial samples.
Review
Chemistry, Medicinal
Claudiu T. T. Supuran
Summary: Carbonic anhydrases (CAs) are widely present in organisms and play important roles in various physiological and pathological processes. Marine natural products have been valuable resources for discovering CA inhibitors, such as sulfonamides, phenols, and polyamines. Psammaplin C and bromophenols have been extensively studied as potential antitumor agents by inhibiting the activities of human CA XII and P-glycoprotein. Marine natural products offer great potential for the development of novel pharmacological agents.
Review
Microbiology
Arumugam Ganeshkumar, Juliana Caparroz Goncale, Rajendran Rajaram, Juliana Campos Junqueira
Summary: This review discusses the significance of marine natural products in controlling the proliferation and metabolism of Candida species, including drug-resistant strains. It highlights the research value of sponges that produce compounds with inhibitory activity against Candida strains. Additionally, the review reveals the mechanisms and synergistic activity of marine products with conventional antifungals. Overall, the majority of compounds derived from the marine environment are capable of controlling specific functions of Candida microorganisms, providing insights into the design of new anti-candidal therapies.
Review
Multidisciplinary Sciences
Md. Mizanur Rahaman, Polrat Wilairatana, Mehedi Hasan Bappi, Tawhida Islam, Md. Nayem Mia, Henrique Douglas Melo Coutinho, Abolghasem Siyadatpanah, Muhammad Torequl Islam
Summary: The majority of the world's nations are experiencing a high cancer mortality rate caused by factors such as an unbalanced diet, genetic factors, and specific environmental substances. In recent years, new compounds with potent anticancer effects have been discovered from plants and marine sources.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)