期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 23, 页码 7219-7222出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.09.050
关键词
Norepinephrine reuptake inhibitor; Dopamine reuptake inhibitor; Dual dopamine and norepinephrine reuptake inhibitors; DAT; NET; ADHD; Depression
Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41. (C) 2012 Elsevier Ltd. All rights reserved.
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