期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 14, 页码 4762-4764出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.05.064
关键词
Calothrixin A; Calothrixin B; N-Alkyl-calothrixins; Indolo[3,2-j]phenanthridine; Antimalarial activity
资金
- Japan Society for the promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [22590010, 23590143, 24590040] Funding Source: KAKEN
We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4 x 10(-6)-1.2 x 10(-7) M. (C) 2012 Elsevier Ltd. All rights reserved.
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