期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 11, 页码 3776-3780出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.04.007
关键词
Bio-inspired synthesis; Colchicine-like compounds; Natural products; Oxidative coupling; Anti-cancer agents
资金
- Skaggs Institute for Research
- National Institutes of Health, USA [AI055475]
- NSF
- Merck
- NIH [K99EB011530]
A bio-inspired investigation of the reactions of substrates of type 1 with VOF3 and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29. (C) 2012 Elsevier Ltd. All rights reserved.
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