Review
Chemistry, Physical
Chang-Qing Qin, Cheng Zhao, Guo-Shu Chen, Yun-Lin Liu
Summary: Catalytic enantioselective azide-alkyne cycloaddition (E-AAC) is an efficient technology for constructing diverse chiral triazoles, with applications in synthetic and medicinal chemistry, biological chemistry, and materials science. Significant developments have been made in copper-, nickel-, iridium-, and rhodium-catalyzed E-AAC reactions in the past six years. This review summarizes these advancements according to different strategies implemented.
Article
Chemistry, Multidisciplinary
Xiao Meng, Shu Xu, Changqing Chen, Lihui Guo, Yuguo Ma
Summary: An efficient topochemical azide-alkyne cycloaddition polymerization of monomers was achieved through a supramolecular approach. The introduction of amide moieties provided hydrogen bonding to strengthen molecular preorganization in the crystal lattice. The prearrangement of azide and alkyne functional groups in the crystalline state facilitated the reaction and resulted in a high regioselectivity to 1,4-triazole products. This research provides a direct and modulatable way for efficient and green polymerizations.
Article
Chemistry, Multidisciplinary
Cecilia Garcia-Oliva, Alejandro Merchan, Almudena Perona, Pilar Hoyos, Angel Rumbero, Maria J. Hernaiz
Summary: Two green strategies, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, based on two activation pathways, for copper-catalyzed azide-alkyne cycloaddition reaction were reported. Glucuronic acid glycodendrimers were synthesized with good conversions (99%), with the microwave pathway being the ideal tool (90% yield in 90 min).
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Priyank Purohit, Akanksha Bhatt, Ravi K. Mittal, Magda H. Abdellattif, Thoraya A. Farghaly
Summary: Polymer grafting is a technique to improve the morphology and properties of polymers. By creating copolymers or grafting, the physicochemical properties of polymers can be further modified. This review discusses various chemical approaches for polymer grafting, such as free radical reactions, click reactions, amide formation, and alkylation. The review also covers the importance of the graft-to approaches and their application in different fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Organic
T. Moritz Weber, Joerg Pietruszka
Summary: Copper-catalyzed alkyne azide click chemistry (CuAAC) is important for drug development and biological materials labeling. A new tridentate Cu-ligand called TDETA was synthesized as a scalable and non-toxic alternative to HN3 and the previously used DTEA ligand. TDETA showed excellent solubility in organic solvents and aqueous solutions, outcompeted commercial ligands THPTA and TBTA for various azide and alkyne combinations using Cu(I) and Cu(II) species, and had a 80% recovery yield.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Applied
Shaik Syed Hussain, Kesavarao Sykam, Ramanuj Narayan, Pratyay Basak
Summary: Si-PUTs were prepared by azide-alkyne cycloaddition, showing excellent surface hydrophobicity and anti-corrosion properties. A simple modification of aminopropyl trimethoxy silane produced a dialkyne terminated monomer, while azide-terminated urethane monomers were synthesized using azidoethanol and common diisocyanates. The successful formation of Si-PUTs was confirmed by FTIR and XPS analysis, and their performance as corrosion resistive coatings was evaluated comprehensively.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Ge Yang, Yali Xie, Yaru Wang, Ying Tang, Leng Leng Chng, Fuyi Jiang, Fanglin Du, Xianfeng Zhou, Jackie Y. Ying, Xun Yuan
Summary: This paper reports on the design of a novel Cu-based nanocatalyst, watersoluble thiolated Cu-30 nanoclusters (NCs), for living cell labeling via CuAAC. The Cu-30 NCs exhibit good biocompatibility, excellent stability, and scalable synthesis, making them a promising catalyst for potential commercial applications. Furthermore, the Cu-30 NCs demonstrate superior catalytic activities for a series of Huisgen cycloaddition reactions with good recyclability, making them suitable for intracellular bioorthogonal applications.
Article
Polymer Science
Ozge Ozukanar, Emrah Cakmakci, Ozgun Daglar, Hakan Durmaz, Volkan Kumbaraci
Summary: The study investigated the use of eugenol as a bio-based building block for the preparation of thermoset materials. By combining thiol-ene photopolymerization and thermal azide-alkyne cycloaddition click reactions, eugenol-based coatings with P-, N-, and Si-containing networks were successfully synthesized. These coatings showed excellent thermal stability, optical transparency, pendulum hardness, solvent resistance, and adhesion performance. They also exhibited high gel content and char yield, and resistance to acidic and basic conditions as well as solvents.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
D. Pal Manisha, Ruchi Chawla, Pradip Kumar Dutta
Summary: A calcium-chitosan-triazole nanocomplex (Ca@CS-Tz) was synthesized using calcium carbide (CaC2) as a source of acetylene. The nanocomplex showed efficient drug delivery, antimicrobial activity against bacteria and fungi, and significant antioxidant property. Targeted drug release experiments were conducted and the nanocomplex demonstrated high release efficiency at pH 5.0 and 7.4. The results were compared with a previously reported chitosan triazole derivative.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Gangam Srikanth Kumar, Stefano Racioppi, Eva Zurek, Qing Lin
Summary: This article reports the design of a super fast bioorthogonal ligation reactant pair, enabling rapid bioorthogonal labeling on live cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Miao Wang, Chau Ming So
Summary: A newly developed phosphine ligand with a C2-cyclohexyl group on the indole ring was successfully applied in a chemoselective Sonogashira coupling reaction, achieving an inversion of the conventional chemoselectivity order. This study also provided an efficient approach to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and the natural product analogue.
Article
Chemistry, Organic
Cong Guan, Jiabin Yin, Jian Ji, Jinhua Liu, Xiang Wu, Tong Zhu, Shunying Liu
Summary: A regioselective electrochemical C-H amination method using easily accessible ethers has been developed to synthesize N (2)-substituted 1,2,3-triazole. Multiple substituents, including heterocycles, were well-tolerated, and 24 examples were obtained in moderate to good yields. Control experiments and DFT calculations revealed that the electrochemical synthesis occurs through a N-tosyl 1,2,3-triazole radical cation process, promoted by single-electron transfer from the lone pair electrons of the aromatic N-heterocycle, and the desulfonation is responsible for the high N (2)-regioselectivity.
Article
Chemistry, Organic
Yulia Krivolapova, Olesya A. Tomashenko, Liya D. Funt, Dar'ya Spiridonova, Mikhail S. Novikov, Alexander F. Khlebnikov
Summary: Azirine-triazole hybrids were selectively synthesized under different reaction conditions and the reaction mechanism and selectivity were discussed based on DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Alex Mapp, Jamie T. Wilmore, Paul D. Beer, Jose M. Goicoechea
Summary: Described the synthesis of a new class of inorganic rotaxanes containing gold(I) triazaphosphole stoppers using the cyaphide-azide 1,3-dipolar cycloaddition reaction. Bis-azides reacted with Au(IDipp)(CP) in aromatic solvents to produce interlocked molecules via an inorganic click reaction. The resulting organometallic rotaxanes were air- and moisture-stable and could be purified under aerobic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Bing Zu, Yonghong Guo, Chuan He
Summary: The catalytic enantioselective construction of boron-stereogenic compounds through asymmetric copper-catalyzed azide-alkyne cycloaddition has been achieved, providing a wide range of novel optically active boron-stereogenic heterocycles with potential applications in chiral optoelectronic materials. This method expands the chemical space of chiroptical boron-based dye platform, showing bright fluorescence and promising optical properties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Inorganic & Nuclear
Shreya Mahato, Amit Mondal, Mainak Das, Mayank Joshi, Partha Pratim Ray, Angshuman Roy Choudhury, C. Malla Reddy, Bhaskar Biswas
Summary: The study introduces a novel type of M(II)-Ce(IV) complex salts and highlights their potential in designing smart functional materials. Structural and morphological properties of the compounds are revealed through analytical and spectroscopic methods. The complex salts were utilized to construct Schottky devices to investigate their role in charge-transport phenomenon.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shibani Mohata, Kaushik Dey, Surojit Bhunia, Neethu Thomas, E. Bhoje Gowd, Thalasseril G. Ajithkumar, C. Malla Reddy, Rahul Banerjee
Summary: Utilizing graphene as a grafting layer, a new method for preparing Janus-type COF-graphene thin films was proposed, demonstrating the fabrication of two distinct Janus-type films with heterogeneous surface morphologies and porosity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Analytical
Sagnik Das, Subhajit Mojumder, Debdulal Saha, Mrinal Pal
Summary: In this review, the significant effects of various parameters on the sensing behavior of semiconductor metal oxide (SMO) based chemiresistive gas sensors have been discussed in detail. The study systematically reviewed the impact of different material and operating condition aspects on the gas sensing performance of SMO sensors. The importance of long-term stability and high-throughput synthesis techniques in practical applications was emphasized, and the future prospects of SMO-based sensors in personalized healthcare were briefly outlined.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Environmental
Michael G. Mazzotta, Christopher M. Reddy, Collin P. Ward
Summary: The study found that marine microbes can degrade cellulose diacetate (CDA) based materials in a matter of months, challenging the belief that CDA-based materials persist in the ocean for decades. This discovery could lead to the identification of high-utility, biobased plastics with low environmental persistence.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Review
Chemistry, Analytical
Stephen A. Wise, Ryan P. Rodgers, Christopher M. Reddy, Robert K. Nelson, Elizabeth B. Kujawinski, Terry L. Wade, Andres D. Campiglia, Zhanfei Liu
Summary: Analytical techniques for chemical analysis of oil and its transformation products have greatly benefited from research following the Deepwater Horizon oil spill. Advanced gas chromatography and high-resolution mass spectrometry have provided a better understanding of the composition and complexity of oil, while novel separation approaches have increased the information available on spilled oil. The development of these techniques is important for future oil spills and investigations into the fate and effects of petroleum and dispersants.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Boyapally Bhaskar, Matta Raghavender, Bandameeda Ramesh Naidu, Katta Venkateswarlu, K. Shiva Kumar
Summary: In the past four decades, tremendous research has been conducted on Pd-catalyzed Suzuki-Miyaura cross-coupling (SMC) due to its significance in constructing biaryl motifs of several complexes and simple organic compounds. The use of organic solid waste-derived materials in benign solvents like water for SMC is a notable achievement. This article reports the usability of water extract of Tamarindus indica seeds ash as a renewable base and reaction medium for Pd(OAc)(2)-catalyzed SMC reaction at room temperature.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Organic
Sailaja Garrepalli, Ramesh Gudipati, Kunta Ravindhranath, Manojit Pal
Summary: This article presents new synthetic methods for the enantiomer (4S, 12aR) and ethoxy acetamide, as well as an environmentally friendly alternative for the synthesis of impurity B. The synthesized impurities were characterized and analyzed, confirming the feasibility and suitability of the developed methods.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Energy & Fuels
Christopher M. Reddy, Robert K. Nelson, Ulrich M. Hanke, Xingqian Cui, Roger E. Summons, David L. Valentine, Ryan P. Rodgers, Martha L. Chacon-Patin, Sydney F. Niles, Carlos E. P. Teixeira, Luis E. A. . Bezerra, Rivelino M. Cavalcante, Marcelo O. Soares, Andre H. B. Oliveira, Helen K. . White, Robert F. Swarthout, Karin L. Lemkau, Jagos R. . Radovic
Summary: From August 2019 to June 2021, viscous oil residues appeared along the Brazilian coast, and the exact source of this mystery oil remains undetermined. However, analysis of samples collected from the coastal zone of Ceara state in 2019 suggests that the oil shares a common origin with samples collected from other regions of Brazil. Possible sources include illegal discharges from vessels, leaking offshore platforms, natural seeps, and historic shipwrecks. The composition of the oil samples indicates a blending of different petroleum products.
Article
Engineering, Environmental
Anna N. Walsh, Michael G. Mazzotta, Taylor F. Nelson, Christopher M. Reddy, Collin P. Ward
Summary: Sunlight can chemically transform marine plastics into various products, but the impact of these light-driven transformations on microbial degradation is not well understood. This study examined the interplay between photochemical and biological degradation of cellulose diacetate (CDA) fabrics, revealing that photodegradation enhanced biodegradation and that the use of titanium dioxide (TiO2) accelerated the process. These findings highlight the importance of plastic formulation on its environmental fate and suggest that the synergy between photochemical and biological degradation should not be overlooked in assessing marine plastic persistence.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Heather O. LeClerc, Geoffrey A. Tompsett, Alex D. Paulsen, Amy M. McKenna, Sydney F. Niles, Christopher M. Reddy, Robert K. Nelson, Feng Cheng, Andrew R. Teixeira, Michael T. Timko
Summary: Food waste is a promising resource for renewable fuel production. The use of hydroxyapatite catalyst in hydrothermal liquefaction can increase biocrude yields and promote condensation reactions. Economic and environmental analysis shows that this technology can reduce greenhouse gas emissions and produce renewable diesel.
Article
Chemistry, Multidisciplinary
Snehasis Mishra, Kaustav Das, Sujan Chatterjee, Panchanan Sahoo, Sudip Kundu, Mrinal Pal, Asim Bhaumik, Chandan Kumar Ghosh
Summary: Carbon dots (CQDs) with tunable fluorescence emission and excitation, high water solubility, good photostability, and biocompatibility are considered promising for tumor theranostics. This study focused on the synthesis and characterization of highly fluorescent CQDs from orange juice. CQD/Ag heterostructures were also synthesized and their photostability and characterization were investigated. Cellular toxicity measurements were conducted to select the superior CQD/Ag heterostructure in the human colorectal carcinoma (HCT 116) cell line, along with the observation of cell death signaling through the ROS-dependent mitochondrial-mediated pathway.
Article
Chemistry, Multidisciplinary
Monalisa Adhikari, Sagnik Das, Dipankar Chattopadhyay, Debdulal Saha, Mrinal Pal
Summary: Recently, there has been significant interest in the precise detection of VOCs, especially acetone, ammonia, and alcohol, due to their importance in industrial safety, environmental monitoring, and human health. This article reports on a chemiresistive sensor based on polypyrrole nanotubes (PPNT) for the selective detection of trace acetone vapor at room temperature. The PPNT sensor demonstrated a high response to trace acetone vapor with a low detection limit and quick response and recovery times.
Article
Chemistry, Multidisciplinary
Narender Addu, Hinuja Miriyala, Ravikumar Kapavarapu, Sunder Kumar Kolli, Manojit Pal
Summary: The synthesis of spiroindoline-3,2'-quinazoline derivatives using Wang-OSO3H as a catalyst and their evaluation against MtbCM (Mycobacterium tuberculosis Chorismate Mutase) in silico and in vitro are reported. The docking studies revealed the binding of these compounds on the external surface pockets of the MtbCM active site cavity.
Article
Chemistry, Multidisciplinary
Gangireddy Sujeevan Reddy, Sharda Shukla, Harshavardhan Bhuktar, Kazi Amirul Hossain, Rebecca Kristina Edwin, Varadaraj Bhat Giliyaru, Parimal Misra, Manojit Pal
Summary: In this study, structurally similar benzofuran derivatives were designed and evaluated for their inhibitory activity against chorismate mutase. The molecules showed strong interactions with the target enzyme and were synthesized in high yields. Three compounds exhibited promising inhibition in vitro and could be of interest in the development of new anti-tubercular agents.
Article
Chemistry, Multidisciplinary
Sagnik Das, Uttam K. Ghorai, Rajib Dey, Chandan K. Ghosh, Mrinal Pal
Summary: This study reports the achievement of highly reproducible, stable, and intense white phosphorescence from phase-pure zinc oxide nanopowder synthesized by a simple, low temperature process. The white light emission has appreciable quantum yield and cool/near cool correlated color temperature, making it suitable for W-LED applications. The presence of zinc interstitial and oxygen interstitial defects responsible for the white phosphorescence was confirmed, and a defect chemistry-based thermodynamic interpretation was proposed to explain the white emission adequately.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
