期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 14, 页码 4575-4578出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.05.110
关键词
Macrolide antibiotics; Desosamine; Erm resistance; Deoxygenation
资金
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1150768] Funding Source: National Science Foundation
Structural factors behind erm macrolide resistance were studied through synthesis of new macrolide derivates possessing truncated desosamine sugar moieties and subsequent determination of their antibacterial activity. Synthesized compounds with 2'-deoxy and 3'-desmethyl desosamine rings demonstrated decreased antibacterial activity on the native Staphylococcus aureus strain and were inactive against constitutively resistance S. aureus. The obtained results indicate that steric repulsion between the dimethylated A2058 and desosamine ring cannot be considered as a primary reason for erm-resistance. (C) 2012 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据