期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 23, 页码 7081-7084出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.087
关键词
Aldolase; Rare sugar; Synthesis; RhaD
资金
- NIH [R01 HD061935, R01 GM085267]
- Georgia State University
- University of South Carolina Salkehatchie
It was previously reported that DHAP-dependent aldolase RhaD selectively chooses L-glyceraldehyde from racemic glyceraldehyde to produce L-fructose exclusively. Contrastingly, we discovered that D-glyceraldehyde is also tolerated as an acceptor and the stereoselectivity of the enzyme is lost in the corresponding aldol addition. Furthermore, we applied this property to efficiently synthesize two rare sugars D-sorbose and D-psicose. (C) 2011 Elsevier Ltd. All rights reserved.
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