Tumor bombesin analog loaded long-circulating and pH-sensitive liposomes as tool for tumor identification

Long-circulating and pH-sensitive liposomes trapping Tc-99m-HYNIC-beta Ala-bombesin((7-14)) (aSpHL-Tc-99m-BBN(7-14)) were successfully prepared. Biodistribution studies and scintigraphic images were performed in Ehrlich tumor-bearing Swiss mice. This system showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Therefore, aSpHL-Tc-99m-BBN(7-14) could be considered as a potential agent for tumor diagnosis. Published by Elsevier Ltd.