期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 21, 页码 6376-6380出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.08.097
关键词
Iron chelator; 3-Hydroxypyridin-4-one; Hexadentate; Antimicrobial activity
资金
- National Natural Science Foundation of China [20972138]
- Ningbo Science and Technology Bureau of China [2007C10066]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry of China [[2009]1590]
- Qianjiang Scholars Fund, Zhejiang Province [2010R10051]
Iron is a critical element for the survival of bacteria. We have designed and synthesized two novel 3-hydroxypyridin-4-one hexadentate ligands with high affinity for iron(III), which disrupt bacterial iron absorption. Biological studies demonstrate that these two chelators have significant inhibitory effect against both Gram-positive and Gram-negative bacteria, and therefore have potential as antimicrobial agents. (C) 2011 Elsevier Ltd. All rights reserved.
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