期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 8, 页码 2497-2501出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.02.045
关键词
Adenosine; A(2A); A(2A) receptor; A(2A) antagonist; Adenosine receptor; Parkinson's disease
Antagonism of the adenosine A(2A) receptor affords a possible treatment of Parkinson's disease. In the course of investigating pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A(2A) antagonists, we prepared [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones with potent and selective (vs A(1)) A(2A) antagonist activity. Structure-activity relationships are described for this series. (C) 2011 Elsevier Ltd. All rights reserved.
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