Article
Biochemistry & Molecular Biology
Sphamandla E. Mtambo, Samuel C. Ugbaja, Hezekiel M. Kumalo
Summary: The emergence of the avian influenza virus H7N9 in China has raised concerns due to its potential to cause serious respiratory diseases in humans. Studies have shown that a specific mutation in the virus can lead to resistance to the antiviral drug peramivir. Molecular dynamics approaches have been used to evaluate the impact of this mutation on drug resistance, revealing changes in the binding affinity and interactions with the drug.
Article
Medicine, General & Internal
Sofia Tejada, Miia Jansson, Candela Sole-Lleonart, Jordi Rello
Summary: Neuraminidase inhibitors (NAIs) therapy significantly reduced the time to clinical resolution, total influenza-related complications, acute otitis media and need for antibiotic treatment. While reductions in mortality, pneumonia, asthma exacerbations, and hospitalization rates only demonstrated a trend benefit with NAIs treatment. The most significant adverse event associated with NAIs was an increase in nausea and vomiting.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sphamandla E. Mtambo, Samuel C. Ugbaja, Aganze G. Mushebenge, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo
Summary: This study investigates the mechanism and dynamics of the E119V mutation on the peramivir-neuraminidase complex of the H7N9 virus. Molecular dynamic simulations and analysis reveal that the E119V substitution confers greater stability on the protein complex. This research provides valuable insights for future drug design and control of avian influenza.
Article
Pharmacology & Pharmacy
Haowen Fang, Yanting Ding, Yi Lu, Bing Niu, Han Lu, Qin Chen
Summary: This study aims to investigate the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase. The results showed that silibinin alters the secondary structure of neuraminidase and inhibits its activity. In conclusion, silibinin can interact with neuraminidase and inhibit its activity.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Medicine, General & Internal
Jen-Wei Liu, Shen-Hua Lin, Lin-Chien Wang, Hsiao-Yean Chiu, Jen-Ai Lee
Summary: This study compared the efficacy and safety of neuraminidase inhibitors and the endonuclease inhibitor for the treatment of seasonal influenza among healthy adults and children. The results showed that zanamivir was associated with the shortest time to alleviation of influenza symptoms, while baloxavir was associated with reduced rate of influenza-related complications.
Article
Chemistry, Medicinal
Hui-Xian Wang, Mao-Sen Zeng, Yi Ye, Jin-Yuan Liu, Pei-Ping Xu
Summary: Puerarin, a major isoflavone compound from Pueraria lobata root, exhibits various properties including anti-inflammatory, antioxidant, and antiviral effects. It shows inhibitory activity against H1N1 influenza virus by blocking viral NP transport and newly formed virus particle release. In vivo studies demonstrate its potential as a treatment for influenza virus infection, with effective antiviral activity and reduced inflammation in the lungs.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sofia Tejada, Alexandre M. Tejo, Yolanda Pena-Lopez, Carlos G. Forero, Xavier Corbella, Jordi Rello
Summary: The study found that baloxavir and neuraminidase inhibitors (NAIs) have a significant reduction effect on complications of uncomplicated influenza, especially in reducing antibiotic prescriptions. Single-dose baloxavir is non-inferior to NAIs in terms of safety and efficacy.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong, Elena A. Govorkova
Summary: Effective antivirals play a crucial role in the early phase of an influenza pandemic, before vaccines are available. Currently, two classes of antiviral drugs are approved for influenza treatment, but resistance has been observed. Therefore, it is important to develop novel antiviral options that target both the virus and the host. This review explores the drawbacks of current antivirals and ongoing research on new agents or combination therapies to address these limitations.
ANTIVIRAL RESEARCH
(2023)
Article
Environmental Sciences
Magdalena Swierczynska, Dagmara M. Mirowska-Guzel, Edyta Pindelska
Summary: This article presents the possibilities of using all available antiviral drugs specific for influenza A and B, and compares the currently recommended anti-influenza medications. It highlights the promising new drug baloxavir marboxil, and suggests further research on combination therapy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Yu-Hsing Fang, Tzu-Herng Hsu, Tzu-Yin Lin, Chia-Hung Liu, Shou-Chu Chou, Jie-Ying Wu, Pang-Chung Perng
Summary: The study compared the efficacy of IV peramivir and oral oseltamivir treatments in influenza patients, showing similar clinical efficacy between the two treatments with no significant difference.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Chemistry, Medicinal
Avishak Sarker, Zichen Gu, Lu Mao, Yongzhuang Ge, Duoduo Hou, Jieyu Fang, Zhanyong Wei, Zhenya Wang
Summary: Influenza is a century-old disease that poses challenges to humans due to its mutating nature, seasonal epidemics, and occasional pandemics. The limited effectiveness of strain-specific vaccines and the growing drug resistance to anti-influenza drugs call for the development of novel drugs with broad reactivity, higher bioavailability, easier administration, and fewer side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Guo-Qiang Zhang, Hao Chang, Zhiyuan Gao, Yang-ping Deng, Sheng Zeng, Luqing Shang, Dan Ding, Qian Liu
Summary: In this study, a neuraminidase-responsive, near-infrared (NIR) fluorescence probe (SA-DCM) with both ratiometric and colormetric properties was reported for various applications. The ratiometric properties of SA-DCM allowed for increased anti-interference capacity, enhanced detection accuracy, and outstanding sensitivity and selectivity. A colorimetric approach was also established using SA-DCM, allowing for direct color conversion on a cotton swab to detect neuraminidase, with simplicity and practicality as the result could be directly read by the naked eye.
ACS MATERIALS LETTERS
(2023)
Article
Immunology
Takuji Komeda, Takahiro Takazono, Naoki Hosogaya, Taiga Miyazaki, Eriko Ogura, Shinpei Iwata, Hideyuki Miyauchi, Keiichi Honda, Masakazu Fujiwara, Yoshikazu Ajisawa, Hideaki Watanabe, Yoshitake Kitanishi, Kanae Hara, Hiroshi Mukae
Summary: This study compared the incidence of hospitalization in patients treated with baloxavir versus oseltamivir and zanamivir for influenza. The results suggest that baloxavir treatment may be more effective in reducing hospitalization rates compared to the other two drugs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Elena A. Govorkova, Emi Takashita, Rod S. Daniels, Seiichiro Fujisaki, Lance D. Presser, Mira C. Patel, Weijuan Huang, Angie Lackenby, Ha T. Nguyen, Dmitriy Pereyaslov, Aine Rattigan, Sook Kwan Brown, Magdi Samaan, Kanta Subbarao, Sun Wong, Dayan Wang, Richard J. Webby, Hui-Ling Yen, Wenqing Zhang, Adam Meijer, Larisa V. Gubareva
Summary: Global analysis showed low susceptibility of influenza viruses to neuraminidase inhibitors (NAIs) and the polymerase acidic (PA) inhibitor baloxavir. NA-H275Y substitution in A(H1N1)pdm09 viruses conferred high resistance to oseltamivir and peramivir. Baloxavir showed reduced susceptibility in a small percentage of viruses, with Japan having a higher rate. Overall, NAIs and baloxavir remain appropriate choices for treating influenza virus infections.
ANTIVIRAL RESEARCH
(2022)
Article
Infectious Diseases
Yu-Hsiang Hsieh, Andrea F. Dugas, Frank LoVecchio, Breana McBryde, Erin P. Ricketts, Kathryn Saliba-Shaw, Richard E. Rothman
Summary: The study compared outcomes of high-risk emergency department patients treated with IV peramivir versus oral oseltamivir, and found that both treatment options were similarly effective in managing influenza infections.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Biochemical Research Methods
Carmen S. Lea, Chakravarthi Simhadri, Stephen G. Bradbury, Jeremy E. Wulff, C. Peter Constabel
Summary: The study developed a method combining aqueous extraction and spray drying to successfully extract and purify oregonin from red alder extract, achieving a purity of over 95%. The developed method was proven to be robust, repeatable, and represented the most complete NMR characterization of oregonin to date.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Chemistry, Physical
Sundiata Kly, Lucas J. Andrew, Erin G. Moloney, Yuhang Huang, Jeremy E. Wulff, Matthew G. Moffitt
Summary: The hierarchical block copolymer self-assembly is utilized to create polyplex-in-hydrophobic-core (PIHC) micelles for gene delivery, which provide nuclease protection and controlled release. The PIHC micelles, generated through a simple two-step process, exhibit efficient encapsulation and slow plasmid release.
CHEMISTRY OF MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Rashid Nazir, Liting Bi, Stefania F. Musolino, Olivia H. Margoto, Kuthan Celebi, Christophe Mobuchon, Mahdi Takaffoli, Abbas S. Milani, Greg Falck, Jeremy E. Wulff
Summary: In this study, a diazirine-grafted polyamine was developed as a topically applied primer for UHMWPE fibers, which improved the adhesion between the fibers and epoxy resin through the formation of covalent bonds. The covalently functionalized surface enhanced the bonding to the epoxy resin and improved the performance of fiber-reinforced composite materials.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Medicine, Research & Experimental
Lisa Silverman, Gitika Bhatti, Jeremy E. Wulff, Matthew G. Moffitt
Summary: In this study, it was found that the encapsulation efficiency of SN-38 in polymer nanoparticles can be significantly increased by curcumin (CUR) through nanoprecipitation. The addition of CUR also led to a decrease in the polydispersity of the nanoparticles. Furthermore, using a microfluidic reactor for nanoprecipitation showed improvements in the encapsulation efficiency of SN-38. Cytotoxicity studies revealed that an optimized formulation of SN-38/CUR-PNPs exhibited stronger potency against certain cancer cells.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Stefania F. Musolino, Fatima Shatila, Grace M. O. Tieman, Anna C. Masarsky, Matthew C. Thibodeau, Jeremy E. Wulff, Heather L. Buckley
Summary: Antimicrobial photodynamic inactivation (APDI) is a promising and greener alternative to conventional antimicrobials. In this study, a tetra-substituted diazirine porphyrin covalently bonded to PET was developed as an antimicrobial surface. The activated surface could generate singlet oxygen and effectively kill Staphylococcus aureus.
Article
Pharmacology & Pharmacy
Derek J. Blevins, Rashid Nazir, Seyed Mohammad Hossein Dabiri, Mohsen Akbari, Jeremy E. Wulff
Summary: A study found that esterases in fetal bovine serum can interfere with disulfide-based prodrug linkers, triggering premature release of cargo. These findings underscore the importance of conducting meticulous control experiments when developing stimulus-release agents for biological applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Minh-Hai Tran, Ian Booth, Bruno G. daFonseca, Peter Berrang, Jeremy E. Wulff, Alexandre G. Brolo
Summary: An economical and facile method has been developed to synthesize a precursor for carbon films and materials. This precursor can be easily coated onto substrates and converted into a graphitic-like structure after mild thermal treatment. This method allows for the coating of glass surfaces of different shapes and forms.
Article
Chemistry, Multidisciplinary
Liting Bi, Benjamin Godwin, Miranda J. Baran, Rashid Nazir, Jeremy E. Wulff
Summary: In this study, chemically cleavable groups were introduced into a bis-diazirine crosslinker, allowing the efficient introduction of molecular crosslinks that can be uncoupled by specific chemical inputs. This method provides a potential strategy for circularization of the thermoplastic/thermoset plastics economy and enables the introduction of functionality into non-functionalized commodity polymers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Benjamin Godwin, Monir H. Anvari, Tina Olfatbakhsh, Mahshid Mahbod, Abbas S. Milani, Gino A. DiLabio, Jeremy E. Wulff
Summary: Chemical cross-links, both irreversible and reversible, can enhance the mechanical strength and rigidity of polymers. In this study, a ketone-functionalized derivative of polydicyclo-pentadiene is introduced, which forms an unprecedented network of vinyl C-H... O hydrogen bonds within the polymer. The resulting thermoset exhibits significantly improved glass transition temperature, storage modulus, Young's modulus, and compression strength compared to the unfunctionalized polymer.
Editorial Material
Multidisciplinary Sciences
Mathieu L. Lepage, Jeremy E. Wulff
Summary: Waste plastics with immiscible polymers pose challenges to recycling. However, a new additive enables the thermal reprocessing of mixed plastics into recyclable, high-performance materials.
Article
Chemistry, Multidisciplinary
Minh-Hai Tran, Ian Booth, Arash Azarakhshi, Peter Berrang, Jeremy Wulff, Alexandre G. Brolo
Summary: This paper introduces a new method for large-scale synthesis of graphene that minimizes the creation of structural defects. The method involves hydrogen functionalization of graphite followed by thermal dehydrogenation, and it is demonstrated to be effective for the preparation of high-quality graphene films.
Article
Polymer Science
Stefania F. Musolino, Mahshid Mahbod, Rashid Nazir, Liting Bi, Hamish A. Graham, Abbas S. Milani, Jeremy E. Wulff
Summary: By electronically optimizing diazirine reagents, their performance can be improved, leading to better stability and efficient C-H insertion in polymers. This enhances the mechanical properties of commodity plastics, reduces loadings, and enables crosslinking at lower temperatures and wavelengths.
Article
Chemistry, Organic
Jonathan K. Sader, Bryce A. Molder, Jeremy E. Wulff
Summary: The study successfully synthesized organic compounds with different functional groups through various reaction pathways, enriching the diversity of synthetic methods. The newly synthesized compounds have potential application value, providing new insights for further research in the field of organic synthesis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Stefania F. Musolino, Zhipeng Pei, Liting Bi, Gino A. DiLabio, Jeremy E. Wulff
Summary: Diazirine reagents can easily generate carbenes under various stimulations, and molecules with diazirine functions have become important tools in a wide range of applications. Through experimental and computational methods, it has been found that the activation energy and temperature of aryl diazirines can be significantly varied by manipulating electronic properties, with electron-rich diazirines showing enhanced efficacy in C-H insertion. These findings are expected to lead to improvements in chemical probes and polymer crosslinkers based on diazirines.
Article
Materials Science, Multidisciplinary
Tong Li, Jeremy E. Wulff
Summary: This study describes a copolymer of dicyclopentadiene with methyl ester functionality which allows for tuning of physical and mechanical properties by changing monomer ratio and thermal curing time while maintaining thermal stability. The copolymers offer improved surface energy control.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
