期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 16, 页码 4720-4723出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.06.081
关键词
MRSA; Low-level VRE; Indole; Arylation
资金
- US National Institutes of Health [RR-16480, CA-135579]
A novel reaction of indole with aryldiazonium salts leading to the formation of 2-aryl-3-(arylazo)indoles was discovered. The products were found to possess potent anti-MRSA and anti-LLVRE activities. The SAR studies indicate that the potentially metabolically labile azo functionality can be replaced with ether oxygen and thioether sulfur atoms without any loss of activity. (C) 2011 Elsevier Ltd. All rights reserved.
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