Article
Radiology, Nuclear Medicine & Medical Imaging
Imad Derraz, Mohamed Abdelrady, Raed Ahmed, Nicolas Gaillard, Riccardo Morganti, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Carlos Riquelme, Lucas Corti, Gregory Gascou, Isabelle Mourand, Caroline Arquizan, Vincent Costalat
Summary: This study aimed to assess whether the burden of white matter hyperintensity (WMH) is associated with an increased risk of symptomatic intracranial hemorrhage (sICH) or poor functional outcome in patients with acute ischemic stroke treated with endovascular thrombectomy (EVT). The results showed that a higher burden of WMH was associated with an increased risk of poor functional outcome at 3 months after EVT.
Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Mingzhu Jiang, Shan Wu, Yunyun Zhang, Yan Li, Bo Lin, Qi Pan, Shufen Tian, Ruihan Ni, Qi Liu, Yingwu Zhu
Summary: This study aimed to investigate the effect of white matter hyperintensity (WMH) and age on gait parameters in middle-aged and geriatric populations. The results showed that Fazekas scores and age were both associated with gait parameters, indicating that WMH could be a clinical warning sign of gait disturbance in a geriatric population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Clinical Neurology
Imad Derraz, Mohamed Abdelrady, Nicolas Gaillard, Raed Ahmed, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Lucas Corti, Carlos Riquelme, Isabelle Mourand, Gregory Gascou, Alain Bonafe, Caroline Arquizan, Vincent Costalat
Summary: This study investigated the association between white matter hyperintensity (WMH) burden and collateral circulation in patients with anterior circulation acute ischemic stroke treated with endovascular thrombectomy, and found that there is no overt relationship between WMH burden and collaterals in large vessel occlusive stroke.
Article
Clinical Neurology
Catriona R. Stewart, Michael S. Stringer, Yulu Shi, Michael J. Thrippleton, Joanna M. Wardlaw
Summary: Cerebral small vessel disease (SVD) is a significant factor in stroke and dementia, with white matter hyperintensities (WMH) contributing to these conditions. Studies have shown that patients with lower cerebral blood flow (CBF) tend to have a heavier burden of WMH, but longitudinal associations remain inconclusive. Further research is needed to determine the role of CBF in the progression of SVD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Sen Zhang, Yaya Hu, Huilin Yang, Qianqian Li, Jing Chen, Hongying Bai
Summary: This study investigated the correlations of white matter hyperintensities (WMH) volume and white matter (WM) volume with cognitive dysfunction in patients with cerebral small-vessel disease (CSVD). It was found that both WMH volume and WM volume were independent risk factors for cognitive dysfunction. WMH volume primarily affected cognitive dysfunction involving visual space and delayed recall, while WM volume was not strongly associated with different types of cognitive dysfunction. The ratio of WMH to WM volume can be used for more accurate evaluation of cognitive dysfunction in older adults with CSVD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Jong-Ho Park, Sun U. Kwon, Hyuk Sung Kwon, Sung Hyuk Heo
Summary: Prior ICH is associated with WMH severity, increasing the risk of both ischemic and hemorrhagic stroke. In patients with ICH, advanced WMH is linked to higher risk of ischemic stroke, while mild WMH is associated with increased risk of hemorrhagic stroke.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Chia-Ling Phuah, Yasheng F. Chen, Jeremy Strain, Nirupama J. Yechoor, Osvaldo M. Laurido-Soto, Beau Ances, Jin-Moo Lee
Summary: The study used a pattern discovery approach to identify distinct spatial patterns of WMH and investigate their association with different etiologies.
Article
Peripheral Vascular Disease
Boyu Zhang, Yajing Huo, Zidong Yang, Huihui Lv, Yilin Wang, Jianfeng Feng, Yan Han, He Wang
Summary: The study found a correlation between blood pressure variability (BPV) and white matter hyperintensity (WMH) volume as well as cerebral arterial dilation. Periventricular WMH showed a stronger association with BPV. Increased BPV may be independently associated with small vessel disease and contribute to intracranial arterial dilation. Therefore, managing BPV may be an important target for preserving cerebrovascular health.
Article
Biology
Joan Jimenez-Balado, Eva Giralt-Steinhauer, Isabel Fernandez-Perez, Lucia Rey, Elisa Cuadrado-Godia, Angel Ois, Ana Rodriguez-Campello, Carolina Soriano-Tarraga, Uxue Lazcano, Adria Macias-Gomez, Antoni Suarez-Perez, Anna Revert, Isabel Estragues, Brigitte Beltran-Marmol, Santiago Medrano-Martorell, Jaume Capellades, Jaume Roquer, Jordi Jimenez-Conde
Summary: Biological age (B-age) is influenced by epigenetics and is calculated based on DNA methylation. Previous research has shown that patients with ischemic stroke have a higher biological age compared to healthy individuals. This study found that patients with a high burden of white matter hyperintensities (WMH) have a higher biological age. Furthermore, B-age explains 42.7% of the effect of chronological age on WMH, suggesting a role of epigenetics in WMH pathology.
Article
Multidisciplinary Sciences
L. A. Dobrynina, A. D. Suslina, M. Gubanova, A. Belopasova, A. N. Sergeeva, S. Evers, E. Gnedovskaya, M. Krotenkova
Summary: In migraine patients without vascular risk factors, different subtypes share a similar pattern of WMH, predominantly located in the juxtacortical and/or deep white matter of the frontal, parietal, and temporal lobes. The number of lesions in the frontal lobe juxtacortical white matter is correlated with patients' age and duration since migraine onset.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Ruiting Zhang, Peiyu Huang, Shuyue Wang, Yeerfan Jiaerken, Hui Hong, Yao Zhang, Xinfeng Yu, Min Lou, Minming Zhang
Summary: This study investigated the association between cerebral blood flow (CBF) and arterial transit with white matter hyperintensities (WMH) and lacunes in patients with cerebral small vessel disease (CSVD). The results showed that both CBF derived from two post-labeling delay times (PLDs) were associated with WMH volume and the presence of lacune. Additionally, delta CBF was correlated with WMH volume but not the presence of lacune. This suggests that delayed arterial transit has an independent effect on WMH.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Christopher E. Bauer, Valentinos Zachariou, Elayna Seago, Brian T. Gold
Summary: This study investigated the associations between three potential early markers of white matter hyperintensity volume and found that white matter microstructure may be a better predictor of WMH volume compared to brain iron concentration and cerebral blood flow. It also highlighted that some early WMH markers may be location-specific.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The article focuses on the pathogenesis and neuroimaging features of white matter lesions (WMLs), revealing a series of pathophysiological findings and discussions about WMLs and providing robust references for clinicians to further understand and customize treatment strategies for different WML patterns caused by vascular etiologies.
Article
Clinical Neurology
Roxana Ameli, Charles R. G. Guttmann, Juan Carlos Prieto, Fabien Rollot, Miklos Palotai, Sandra Vukusic, Romain Marignier, Francois Cotton
Summary: This study retrospectively analyzed MRI scans of 54 NMOSD patients and found that patients with lesions in hAQP4 and lesions evocative of NMOSD exhibited significantly more extensive myelitis.
JOURNAL OF NEURORADIOLOGY
(2021)
Review
Clinical Neurology
Miklos Palotai, Charles R. G. Guttmann
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Clinical Neurology
Miklos Palotai, Michele Cavallari, Ismail Koubiyr, Alfredo Morales Pinzon, Aria Nazeri, Brian C. Healy, Bonnie Glanz, Howard L. Weiner, Tanuja Chitnis, Charles R. G. Guttmann
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Roca, A. Attye, L. Colas, A. Tucholka, P. Rubini, S. Cackowski, J. Ding, J. -F. Budzik, F. Renard, S. Doyle, E. L. Barbier, I. Bousaid, R. Casey, S. Vukusic, N. Lassau, S. Verclytte, F. Cotton
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2020)
Correction
Anatomy & Morphology
Fernanda Troili, Virginia Cipollini, Marco Moci, Emanuele Morena, Miklos Palotai, Virginia Rinaldi, Carmela Romano, Giovanni Ristori, Franco Giubilei, Marco Salvetti, Francesco Orzi, Charles R. G. Guttmann, Michele Cavallari
FRONTIERS IN NEUROANATOMY
(2020)
Article
Clinical Neurology
Mattia Rosso, Brian C. Healy, Shrishti Saxena, Anu Paul, Kjetil Bjornevik, Jens Kuhle, Pascal Benkert, David Leppert, Charles Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: This study investigated the relationship between serum neurofilament light levels and age in multiple sclerosis patients, revealing a more significant increase in sNfL levels after Gad+ lesions in younger patients. This insight provides new understanding of the effects of neuroinflammation on aging in MS.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Madhvi Deol, Miklos Palotai, Alfredo Morales Pinzon, Andrzej Marciniak, Gregory Bliault, Etta Covert, Ayal Aizer, Jeffrey P. Guenette, Matthew N. Desalvo, Xiao Tian Li, Aaron Thomas, Ngoc-Anh Tran, Alex Jacobson, Raymond Huang, Charles R. G. Guttmann
Summary: This study evaluated the impact of education level on the reproducibility of LM scoring, finding that structured education using the SPINE platform may improve consistency in LM reporting. In general, agreement on LM characteristics was higher between attending neuroradiologists than fellows or residents.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Miklos Palotai, Catherine Small, Nikolaos Makris, Nathaniel G. Somes, Alfredo Morales Pinzon, Yogesh Rathi, Aldo Marzullo, James J. Levitt, Rohit Bakshi, Tanuja Chitnis, Charles R. G. Guttmann
Summary: The study found that in patients with multiple sclerosis (MS), fatigue and depression were associated with microstructural changes in the left mesocorticolimbic reward pathway (slMFB), which may contribute to the comorbid development of fatigue and depression.
JOURNAL OF NEUROIMAGING
(2021)
Article
Multidisciplinary Sciences
Arman Eshaghi, Alexandra L. Young, Peter A. Wijeratne, Ferran Prados, Douglas L. Arnold, Sridar Narayanan, Charles R. G. Guttmann, Frederik Barkhof, Daniel C. Alexander, Alan J. Thompson, Declan Chard, Olga Ciccarelli
Summary: The study utilized an unsupervised machine learning algorithm to determine multiple sclerosis subtypes, progression, and response to potential therapeutic treatments based on neuroimaging data.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Katharina Schregel, Caroline Baufeld, Miklos Palotai, Roberta Meroni, Paolo Fiorina, Jens Wuerfel, Ralph Sinkus, Yong-Zhi Zhang, Nathan McDannold, P. Jason White, Charles R. G. Guttmann
Summary: EAE is a model of multiple sclerosis with moderate reproducibility, but lacks focal lesions observed in MS, making it difficult to assess the pathogenesis of lesion evolution. Using focused ultrasound to induce blood brain barrier disruption in EAE mice, we observed focal brain lesions with increased inflammatory activity reflected in changes of biomechanical parameters.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Miklos Palotai, Max Wallack, Gergo Kujbus, Adam Dalnoki, Charles Guttmann
Summary: This study introduced a novel mobile app designed to differentiate fatigue phenotypes and investigate brain MRI correlates of MS-related fatigue. The majority of patients showed reasonable compliance when using the app in a prospective study.
JMIR MHEALTH AND UHEALTH
(2021)
Correction
Multidisciplinary Sciences
Arman Eshaghi, Alexandra L. Young, Peter A. Wijeratne, Ferran Prados, Douglas L. Arnold, Sridar Narayanan, Charles R. G. Guttmann, Frederik Barkhof, Daniel C. Alexander, Alan J. Thompson, Declan Chard, Olga Ciccarelli
NATURE COMMUNICATIONS
(2021)
Review
Clinical Neurology
Hugo Vrenken, Mark Jenkinson, Dzung L. Pham, Charles R. G. Guttmann, Deborah Pareto, Michel Paardekooper, Alexandra de Sitter, Maria A. Rocca, Viktor Wottschel, M. Jorge Cardoso, Frederik Barkhof
Summary: Patients with multiple sclerosis have diverse clinical presentations and symptoms, making it difficult to assess and understand the disease. Utilizing large-scale data sharing and artificial intelligence can enhance image analysis and provide insights into disease processes. This includes training AI algorithms on validated reference data and detecting relevant patterns in large MS cohorts, ultimately improving the understanding of MS.
Article
Neuroimaging
Alexandra de Sitter, Jessica Burggraaff, Fabian Bartel, Miklos Palotai, Yaou Liu, Jorge Simoes, Serena Ruggieri, Katharina Schregel, Stefan Ropele, Maria A. Rocca, Claudio Gasperini, Antonio Gallo, Menno M. Schoonheim, Michael Amann, Marios Yiannakas, Deborah Pareto, Mike P. Wattjes, Jaume Sastre-Garriga, Ludwig Kappos, Massimo Filippi, Christian Enzinger, Jette Frederiksen, Bernard Uitdehaag, Charles R. G. Guttmann, Frederik Barkhof, Hugo Vrenken
Summary: This study successfully established a standardized protocol for manual delineations of deep grey matter structures, demonstrating good reliability among different raters. The fast-semi-automated segmentation approach FASTSURF showed high accuracy in reproducing complete segmentations of deep grey matter based on sparse delineations.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Jessica Burggraaff, Yao Liu, Juan C. Prieto, Jorge Simoes, Alexandra de Sitter, Serena Ruggieri, Iman Brouwer, Birgit Lissenberg-Witte, Mara A. Rocca, Paola Valsasina, Stefan Ropele, Claudio Gasperini, Antonio Gallo, Deborah Pareto, Jaume Sastre-Garriga, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Olga Ciccarelli, Hanneke E. Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard M. J. Uitdehaag, Hugo Vrenken, Charles R. G. Guttmann
Summary: Thalamus atrophy has been consistently associated with cognitive decline in multiple sclerosis (MS), and both manual and automated segmentation methods demonstrate this correlation. However, there may be a proportional bias in smaller thalami, and the choice of MRI vendor can also impact the findings.
NEUROIMAGE-CLINICAL
(2021)