期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 23, 页码 6950-6954出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.133
关键词
CCR5; Chemokine receptor; HIV-1; Schering C
A series of CCR5 antagonists were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of alpha-glycoprotein were evaluated in rat and dog pharmacokinetics. (C) 2011 Elsevier Ltd. All rights reserved.
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