期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 12, 页码 3583-3586出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.04.107
关键词
Imidacloprid; Neonicotinoid insecticides; Nicotinic acetylcholine receptor; Haloacetylimino pharmacophore
资金
- National Science Foundation [CHE-0840505]
- Direct For Mathematical & Physical Scien [840505] Funding Source: National Science Foundation
- Division Of Chemistry [840505] Funding Source: National Science Foundation
This structure-activity relationship study for neonicotinoids with an N-haloacetylimino pharmacophore identifies several candidate compounds showing outstanding insecticidal potency and consequently leads to establishing their molecular recognition at an insect nicotinic receptor structural model, wherein the neonicotinoid halogen atoms (fluorine, chlorine, bromine, and iodine) variously interact with the receptor loops C-D interfacial niche via H-bonding and/or hydrophobic interactions. (C) 2011 Elsevier Ltd. All rights reserved.
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