Article
Medicine, Research & Experimental
Qiuxia Li, Quanjiang Zhang
Summary: MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression by binding to the mRNAs of protein-coding genes. In endothelial cells, miR-34a is an early identified miRNA that plays important roles in regulating endothelial functions, angiogenesis, differentiation, senescence, inflammatory response, responses to shear stress, and mitochondrial function. This review provides an overview of the current understanding of miR-34a in endothelial biology and discusses its potential as a therapeutic target for vascular diseases.
Article
Biochemistry & Molecular Biology
Min Joung Lee, Yunseon Jang, Jiebo Zhu, Eunji Namgung, Dahyun Go, Changjun Seo, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Hyoeun Kang, Hyeongseok Kim, Woosuk Chung, Jun Young Heo
Summary: Auraptene enhances junction assembly in cerebrovascular endothelial cells by inducing antioxidant enzymes and the mitochondrial unfolded protein response, protecting against oxidative stress and improving barrier function.
Review
Neurosciences
Luc Bertrand, Martina Velichkovska, Michal Toborek
Summary: HIV infection is associated with comorbidities likely driven by HIV and long-term use of antiretroviral therapy (ART). Antiretroviral drugs used for HIV treatment can have toxic effects, particularly on the blood-brain barrier (BBB). Balancing health risks and gains of ART is crucial for maximizing therapy's positive effects.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Clinical Neurology
Taylor E. Branyan, Amutha Selvamani, Min Jung Park, Kriti E. Korula, Kelby F. Kosel, Rahul Srinivasan, Farida Sohrabji
Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Neurosciences
Min Joung Lee, Jiebo Zhu, Jong Hun An, Seong Eun Lee, Tae Yeon Kim, Eungseok Oh, Yea Eun Kang, Woosuk Chung, Jun Young Heo
Summary: This study found that the Notch1 signaling pathway is associated with BBB disruption caused by endothelial mitochondrial dysfunction. Activation of Notch1 may help protect BBB integrity and reduce the severity of acute brain injuries.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Biochemistry & Molecular Biology
Krzysztof Milewski, Karolina Orzel-Gajowik, Magdalena Zielinska
Summary: The mechanisms underlying cerebral vascular dysfunction and edema during hepatic encephalopathy (HE) are unclear. This review focuses on the possible involvement of mitochondrial dysfunction in the status of brain endothelial cell mitochondria in HE.
NEUROCHEMICAL RESEARCH
(2022)
Article
Clinical Neurology
Albert Puig-Pijoan, Joan Jimenez-Balado, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Jose Contador, Rosa-Maria Manero-Borras, Victor Puente-Periz, Antoni Suarez, Francisco J. Munoz, Oriol Grau-Rivera, Marc Suarez-Calvet, Rafael de la Torre, Jaume Roquer, Angel Ois
Summary: This study explored the association between blood-brain-barrier permeability (BBBp) and cognitive decline progression. The results suggested that increased BBBp may contribute to clinical worsening in individuals with cognitive decline, indicating potential targeted therapies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Keri Callegari, Sabyasachi Dash, Hiroki Uchida, Yuto Shingai, Catherine Liu, Anne Khodarkovskaya, Yunkyoung Lee, Akira Ito, Amanda Lopez, Tuo Zhang, Jenny Xiang, Michael J. Kluk, Teresa Sanchez
Summary: Stroke-induced cerebral microvascular dysfunction aggravates neuronal injury and affects the efficacy of reperfusion therapies. Studying molecular changes in cerebral microvessels during stroke can lead to new therapeutic strategies. By analyzing mouse stroke microvessels and human stroke lesions, we identified common alterations and molecular features related to vascular disease, endothelial activation, and sphingolipid metabolism and signaling. Our study provides valuable insights for the development of neurovascular protection in stroke and other conditions with cerebral microvascular dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Utkarsh Bhardwaj, Sunit K. Singh
Summary: Zika virus disrupts the barrier integrity of the blood-brain barrier through NS1 protein and hsa-miR-101-3p interaction, which may contribute to neurological diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Oncology
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu
Summary: Smyd2 plays a vital role in disrupting blood-brain barrier integrity in ischaemic stroke through methylation-mediated Sphk/S1PR, and knocking down Smyd2 reduces blood-brain barrier permeability and improves functional recovery.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yue-yue Wang, Chun-feng Jiang, Xin Liu, Jian-nan Li, Guang-zhi Cai, Ji-yu Gong
Summary: The study revealed that protein downregulation of P-gp significantly activated RA transmembrane activity, showing P-gp's responsibility for RA cellular trafficking. In addition, the selective non-specific inhibitor, LY335979, increased the intracellular accumulation of RA by restricting transporter's function. Decreased expression or activity of P-gp triggered RA drug resistance to HBMECs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Hematology
Felecia M. Marottoli, Hui Zhang, Eden Flores-Barrera, Emilce Artur de la Villarmois, Frederick C. Damen, Anabel M. M. Miguelez Fernandez, Hannah V. Blesson, Rohan Chaudhary, Anthony L. Nguyen, Amanda E. Nwokeji, Ruju Talati, Ashwin S. John, Kushi Madadakere, Sarah E. Lutz, Kejia Cai, Kuei Y. Tseng, Leon M. Tai
Summary: The loss of endothelial cell APOE3 expression leads to neurovascular dysfunction and abnormalities in neural function. This finding supports the importance of endothelial cell APOE3 in neurovascular regulation, neural circuit function, and behavior.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuhui Ge, Pengyu Tang, Yuluo Rong, Dongdong Jiang, Xiao Lu, Chengyue Ji, Jiaxing Wang, Chenyu Huang, Ao Duan, Yang Liu, Xinglin Chen, Xichen Chen, Zhiyang Xu, Feng Wang, Zibin Wang, Xiaoyan Li, Wene Zhao, Jin Fan, Wei Liu, Guoyong Yin, Weihua Cai
Summary: The study revealed that M1-BMDMs promote EndoMT of vascular endothelial cells, exacerbating BSCB disruption after SCI and causing dysfunction of mitochondria and accumulation of ROS. Exosomal miR-155/SOCS6/p65 axis plays a crucial role in regulating EndoMT process and mitochondrial function in vascular endothelial cells.
Article
Cell Biology
Utkarsh Bhardwaj, Sunit K. Singh
Summary: Zika virus infection can cause microcephaly in newborns, and its NS1 protein can disrupt the barrier function of endothelial cells by regulating the expression of junctional proteins through the hsa-miR-29b-3p/DNMT3b/MMP-9 pathway.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Multidisciplinary
Cheng-di Liu, Nan-nan Liu, Sen Zhang, Guo-dong Ma, Hai-guang Yang, Ling-lei Kong, Guan-hua Du
Summary: The study demonstrates that pretreatment with salvianolic acid A (SAA) can significantly improve neurological deficits, intracerebral hemorrhage, BBB disruption, and vascular endothelial dysfunction caused by ischemia, indicating its potential therapeutic strategy for the prevention of ischemic stroke by suppressing the Src signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Neurosciences
S. Sarkar, S. Jun, S. Rellick, D. D. Quintana, J. Z. Cavendish, J. W. Simpkins
Article
Endocrinology & Metabolism
Dominic D. Quintana, Xuefang Ren, Heng Hu, Elizabeth B. Engler-Chiurazzi, Stephanie L. Rellick, Sara E. Lewis, Jessica M. Povroznik, James W. Simpkins, Mohammad Alvi
METABOLIC BRAIN DISEASE
(2018)
Article
Cell Biology
Dominic D. Quintana, Jorge A. Garcia, Saumyendra N. Sarkar, Sujung Jun, Elizabeth B. Engler-Chiurazzi, Ashley E. Russell, John Z. Cavendish, James W. Simpkins
Article
Neurosciences
John Z. Cavendish, Saumyendra N. Sarkar, Mark A. Colantonio, Dominic D. Quintana, Nadia Ahmed, Brishti A. White, Elizabeth B. Engler-Chiurazzi, James W. Simpkins
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Neurosciences
S. Sarkar, E. B. Engler-Chiurazzi, J. Z. Cavendish, J. M. Povroznik, A. E. Russell, D. D. Quintana, P. H. Mathers, J. W. Simpkins