期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 11, 页码 3358-3361出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.04.017
关键词
AMPA receptor antagonists; Anticonvulsants; Excitatory amino acids; Glutamate receptors; Quinazoline-2,4-dione sulfonamides
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models. (C) 2011 Elsevier Ltd. All rights reserved.
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