期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 21, 页码 6398-6403出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.08.095
关键词
Antifungal; Antibacterial; Surfactant; Sodium dodecyl sulfate (SDS); 2,3-Dichloro-1,4-naphthoquinone; Green chemistry; Phenol; Water
资金
- C.S.I.R., New Delhi, India [01(2280)/08/EMR-II]
Various oxygen containing 1,4-naphthoquinone derivatives have been synthesized chemoselectively by an economical, viable green methodology approach using water as solvent with or without surfactants such as Triton X-100, SDS, LD (laundry detergent), and TBAB, a phase transfer catalyst and evaluated for their in vitro antifungal and antibacterial activity. The antifungal profile of 3, 4a, 4b, and 6 indicated that compounds 3a, 3b, 4b, 6a, and 6c have potent antifungal activity compared to clinically prevalent antifungal drugs Fluconazole and Amphotericin-B against Sporothrix schenckii, Trichophyton mentagraphytes, and Candida parapsilosis and compound 3b has been found to be a lead antifungal agent for further study. (C) 2011 Elsevier Ltd. All rights reserved.
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