期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 17, 页码 4956-4959出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.06.057
关键词
Sulfur metabolism; CysQ; Phosphatase; Sulfation; Glycolipids
资金
- National Institutes of Health [AI51622, AI72133]
CysQ is a 3'-phosphoadenosine-5'-phosphatase that dephosphorylates intermediates from the sulfate assimilation pathway of Mycobacterium tuberculosis (Mtb). Here, we demonstrate that cysQ disruption attenuates Mtb growth in vitro and decreases the biosynthesis of sulfated glycolipids but not major thiols, suggesting that the encoded enzyme specifically regulates mycobacterial sulfation. (C) 2011 Elsevier Ltd. All rights reserved.
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