Article
Chemistry, Multidisciplinary
Nisheeth C. Desai, Kandarp Bhatt, Jahnvi Monapara, Unnat Pandit, Vijay M. Khedkar
Summary: Microwave-assisted organic reaction enhancement (MORE) is becoming increasingly important in synthetic organic chemistry for efficient resource utilization. The microwave-assisted synthesis method allows for quicker synthesis with higher yields and better quality compounds compared to traditional methods.
Review
Chemistry, Organic
Deepika Dwarakanath, Santosh L. Gaonkar
Summary: Benzofurans, as a class of heterocycles with pharmaceutical and therapeutic properties, have attracted significant attention in recent years. The chemistry and synthesis of benzofurans and their derivatives have shown important advances, and these derivatives exhibit notable anti-tumor, anti-fungal, anti-mycobacterial, and anti-oxidant activities.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sarvesh Kumar Pandey, Umesh Yadava, Anjali Upadhyay, M. L. Sharma
Summary: A series of novel quinazolinone hybrids were synthesized in this study, and their in vitro antimicrobial and antifungal activities were evaluated, demonstrating that compound 8b exhibited the best inhibitory activity against pathogenic bacteria. Additionally, molecular docking studies showed that these compounds have potent inhibitory properties and could be considered as potential inhibitors towards selective targets.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Montajar Sarkar, Rumana Hossain, Veena Sahajwalla
Summary: Concerns over resource limitations and environmental pollution have prompted the adoption of a circular economy focused on converting waste into resources. This study demonstrates the synthesis of microzonal carbon through the microrecycling of waste hard rubber using both conventional and microwave heating methods. The results suggest that microwave heating offers rapid and selective changes in the structural properties of microzonal carbon compared to conventional heating, leading to the formation of near-spherical agglomerated microzonal carbon. Additionally, this microrecycling process can contribute to environmental protection and material sustainability.
Article
Chemistry, Multidisciplinary
Kejun Liu, Rui Luo, Jiaxu Fu, Lijian Bao, Yafei Xue, Qiang Gu, Yumin Zhang, Feng Lin
Summary: An efficient synthesis of 1,2,5-trisubstituted benzimidazoles was achieved using microwave irradiation and K2CO3. Twenty novel compounds were prepared in moderate to excellent yield within 15 minutes. The reaction showed broad substrate adaptability, and the effect of different substituents on the yield was investigated. The synthesized compounds exhibited significant antibacterial activity against Mycobacterium smegmatis, with compound 4s showing the best activity surpassing rifampicin.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Nisheeth C. Desai, Ghanshyam M. Kotadiya, Krunalsinh A. Jadeja, Keyur N. Shah, Alimamad H. Malani, Vijjulatha Manga, Tamalapakula Vani
Summary: By synthesizing quinoline bearing dihydropyrimidine analogues, promising results have been achieved in terms of structure determination and molecular properties prediction, with compound 5m showing excellent anti-tubercular activity and drug-likeness.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Afzal B. Shaik, Richie R. Bhandare, Srinath Nissankararao, Bontha Venkata Subrahmanya Lokesh, Shaik Shahanaaz, M. Mukhlesur Rahman
Summary: A series of new chloropyrazine conjugated benzothiazepines were synthesized and evaluated for their antitubercular, antimicrobial, and cytotoxic activities. Some compounds exhibited significant activities and could be considered as potential leads for drug development.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Food Science & Technology
Atul Dhiman, Kavita Thakur, Vijaya Parmar, Savita Sharma, Rajan Sharma, Gurkirat Kaur, Baljit Singh, Rajat Suhag
Summary: The popularity of plant-based proteins has greatly increased in recent years due to their health-promoting effects, environmental friendliness, the ability to overcome malnutrition and sustainability challenges. However, their functional properties have limited their use as key ingredients in comparison to animal proteins. Plant proteins have lower digestibility and lack certain techno-functional properties required for the development of plant-based food products. In order to improve the quality, functionality, and digestibility of plant proteins, novel processing technologies such as high-pressure processing, microfluidization, electrospraying, and ultrasounds have been employed. These techniques enhance the application of plant proteins as functional ingredients, increasing their solubility, gelation, water holding capacity, emulsifying, and foaming properties.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Chemistry, Medicinal
Dorothy Semenya, Meir Touitou, Domiziana Masci, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Guilherme Felipe Dos Santos Fernandes, Beatrice Gianibbi, Fabrizio Manetti, Daniele Castagnolo
Summary: The exploration around the 2,5-dimethylpyrrole scaffold of antitubercular hit compound 1 has led to the discovery of new derivatives that are active against Mycobacterium tuberculosis and multidrug-resistant clinical isolates. Some of these derivatives showed promising cytotoxicity profiles and were effective in inhibiting the growth of intracellular mycobacteria.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Perumal Sarojini, Malaichamy Jeyachandran, Dharmarajan Sriram, Palraj Ranganathan, S. Gandhimathi
Summary: Novel 2-(aryloxymethyl)aziridines and 2((3-aryl-1-phenylallyloxy)methyl)aziridine derivatives were synthesized and evaluated for their antitubercular activities, showing promising results with some compounds exhibiting three-times more activity than standard drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Organic
Nisheeth C. Desai, Jalpa P. Harsora, Jahnvi D. Monapara, Vijay M. Khedkar
Summary: A new set of molecules with potential antimicrobial activity was designed and synthesized. These molecules showed activity against both bacterial and fungal strains, with some compounds being active against specific strains. Furthermore, the presence of electron-releasing substituents significantly influenced the antimicrobial activity of the compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Food Science & Technology
SeHyuk Kim, Hyuk Choi, YoonHee Lee, JaeHwan Lee
Summary: Microwave treatment and conventional heating have different effects on the degree of oxidation and volatile profiles in corn oils. Microwave treatment may accelerate the rate of lipid oxidation, but generate fewer volatile compounds.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Siddappa A. Patil, Shivaputra A. Patil, Temilade Fariyike, Kostiantyn O. Marichev, Hector Mario Heras Martinez, Alejandro Bugarin
Summary: Coumarins, a family of naturally occurring heterocyclic ring systems, have been found to exhibit various therapeutic characteristics when bearing azetidinone and thiazolidinone moieties, including antimicrobial, anticancer, antidiabetic, and anti-inflammatory properties. Studies have shown that advances in synthetic methodologies and structure-activity relationships of coumarins have led to increased interest from researchers in various fields.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Archna Yadav, C. P. Kaushik, Mukesh Kumar
Summary: A series of hydrazones tethered 1,4-disubstituted 1,2,3-triazoles were synthesized from novel N-substituted alkynes derived from benzohydrazides and benzyl bromides through Cu(I) catalyzed 1,3-dipolar cycloaddition reaction. The synthesized compounds were characterized by various spectroscopic techniques and the crystal structure of one compound was determined by X-ray crystallography. The compounds were evaluated for their antimicrobial and antitubercular activities, and two compounds showed promising results. Molecular docking studies and in-silico ADME studies were also conducted to understand the mode of action and the potential of the synthesized triazoles as drug agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Ankush Chauhan, Swati Kumari, Ritesh Verma, Vishal Dutta, Suresh Ghotekar, Manpreet Kaur, Saurabh Kulshrestha, Karambir Singh, Kun-Yi Andrew Lin, Rajesh Kumar
Summary: In this study, copper oxide nanoparticles (CuO-NPs) were synthesized using microwave irradiation and a green synthesis approach. The addition of Zanthoxylum armatum plant extract led to a decrease in particle size and an increase in absorption intensity. TEM images showed well-defined grain boundaries for samples synthesized with the plant extract, while diffused grains were observed for samples synthesized without the extract. Furthermore, the antimicrobial activity of CuO-NPs was influenced by the presence of chemisorbed species on the surface.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)