期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 19, 页码 5677-5680出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.08.024
关键词
Indoloditerpene; Aspergillus oryzae; Endophytic fungus; Heterosiphonia japonica; Red alga
资金
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-QN209, KZCX2-YW-225, KSCX2-YW-G-073]
- Shandong Province Natural Science Foundation [ZR2009BQ021]
- Yantai Municipal Sci-Tech Development Program [2009164]
- Foundation of the Chinese Academy of Sciences
Two new indoloditerpene derivatives asporyzin A (1) and asporyzin B (2), one new indoloditerpene asporyzin C (3), and three known related indoloditerpenes JBIR-03 (4), emindole SB (5), and emeniveol (6) were isolated from an endophytic fungus Aspergillus oryzae, isolated from the marine red alga Heterosiphonia japonica. Their structures were unambiguously established by spectroscopic techniques. In addition, all the isolates were evaluated preliminarily for insecticidal and antimicrobial activities in order to probe into their chemical defensive function. Compound 4 was more active against brine shrimp than the others, and 3 possessed potent activity against Escherichia coli. (C) 2010 Elsevier Ltd. All rights reserved.
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